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| 2. |
- Peden, John F., et al.
(författare)
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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:4, s. 339-344
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
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| 3. |
- Mahmood, Nabeel S., et al.
(författare)
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Analysis of Slope Stability and Soil Liquefaction of Zoned Earth Dams Using Numerical Modeling
- 2022
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Ingår i: International Journal of Design & Nature and Ecodynamics. - : International Information and Engineering Tachnology Association. - 1755-7437 .- 1755-7445. ; 17:4, s. 557-562
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Tidskriftsartikel (refereegranskat)abstract
- The design of dams requires comprehensive studies to ensure the safety and feasibility of these important engineering projects, as any possible failure case may lead to considerable losses in human life and properties. Specifically, analyses should be performed to evaluate seepage, slope stability, and soil liquefaction of large earth dams. In this study, numerical modeling, based on finite element methods, was used to analyze seepage, slope stability, and liquefaction of Makhoul Dam which is a large zoned dam, currently under construction on Tigris River in the north of Iraq. Earthquake shakings impose additional hysteric and short-term loads that may lead to dam failure due to high pore water pressure, piping, and soil liquefaction. Therefore, the dynamic stability of the dam and soil liquefaction were also evaluated, as a result of applying an earthquake shaking to the dam. For the static condition, the dam was safe against internal erosion and slope failure, as the calculated value of the safety factor was greater than the allowable value. However, the results obtained from the dynamic analysis indicated that a possible earthquake, with an acceleration of 0.38g and 10 seconds period, led to upstream slope failure, a relative displacement as high as 2 meters at the dam crest, and soil liquefaction at the upstream slope. As discussed herein, dam redesign or geotextile reinforcement may be considered to reduce the effects of earthquakes on the dam.
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| 4. |
- Mahmood, Nabeel S., et al.
(författare)
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Seepage Problem Through the Foundation of a Spillway with Selected Treatment Methods
- 2022
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Ingår i: Mathematical Modelling of Engineering Problems. - : International Information and Engineering Technology Association. - 2369-0739 .- 2369-0747. ; 9:3, s. 819-824
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Tidskriftsartikel (refereegranskat)abstract
- One of the main concerns for engineers, during operation of dams, is uncontrolled seepage though the foundations of dams and hydraulic structures which is mainly resulted from poor geological conditions and lead to undermine erosion or piping that may endanger the safety of dam. In this study, numerical models were utilized to evaluate the excessive seepage problem underneath the spillway of Horan 2 Dam in Iraq as the seepage have led to dissipate storge and malfunction the dam. Two treatment methods were proposed to reduce the quantity of seepage by using a cutoff wall and a clay blanket. The results of the models indicated that the foundation of the spillway was unsafe against piping, as the calculated factor of safety was less than the allowable value. A clay blanket of 6 m long is recommended to sufficiently reduce the quantity of seepage and maintain the factor of safety within the allowable limits. As the cut off wall and clay blanket were used, the quantity of seepage decreased up to 73% and 96%, respectively, and the safety factor increased up to 100% and 110%, respectively. As discussed herein, using a clay blanket is the most cost-effective method comparing to using a cutoff wall.
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| 6. |
- Nabeel, M., et al.
(författare)
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Characterization of inclusions in high-Mn steel using two-dimensional and three-dimensional methods
- 2019
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Ingår i: Iron & Steel Technology. - : Association for Iron & Steel Technology. - 1547-0423. ; 16:7, s. 74-82
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Tidskriftsartikel (refereegranskat)abstract
- The characteristics of inclusions in high-manganese steel samples from laboratory-scale experiments were investigated. This was done by two-dimensional and three-dimensional methods. In the two-dimensional investigations, inclusions on polished cross-sections were observed by using automatic scanning electron microscopy analysis. For the three-dimensional investigations, inclusions collected on a film filter after electrolytic extraction were observed. It was found that electrolytic extraction could be successfully applied to high-manganese steels. Further, automatic analysis, which is a common practice in steel industry, has limitations for the detection and classification of nitride inclusions, whereas it was possible to detect nitrides using the three-dimensional method.
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