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> (2021)
> Molinuevo José Luis >
Sex-Specific Metabo...
Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort
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- Xu, Jin (author)
- Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
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- Green, Rebecca (author)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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- Kim, Min (author)
- Steno Diabetes Center, Gentofte, Denmark
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show more...
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- Lord, Jodie (author)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
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- Ebshiana, Amera (author)
- Institute of Pharmaceutical Science, King's College London, London, UK
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- Westwood, Sarah (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Baird, Alison L. (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Nevado-Holgado, Alejo J. (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Shi, Liu (author)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Hye, Abdul (author)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
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- Snowden, Stuart G. (author)
- Institute of Pharmaceutical Science, King's College London, London, UK
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- Bos, Isabelle (author)
- Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Vos, Stephanie J. B. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Vandenberghe, Rik (author)
- Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
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- Teunissen, Charlotte E. (author)
- Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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- Kate, Mara Ten (author)
- Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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- Scheltens, Philip (author)
- Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
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- Gabel, Silvy (author)
- Department of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands; Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
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- Meersmans, Karen (author)
- Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
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- Blin, Olivier (author)
- Clinical Pharmacology & Pharmacovigilance Department, Aix-Marseille University-CNRS, Marseille, France
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- Richardson, Jill (author)
- Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
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- De Roeck, Ellen Elisa (author)
- Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
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- Engelborghs, Sebastiaan (author)
- Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Center for Neurosciences (C4N), UZ Brussel and Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium
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- Sleegers, Kristel (author)
- Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium
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- Bordet, Régis (author)
- Department of Medical Pharmacology, Université de Lille, Lille, France
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- Rami, Lorena (author)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
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- Kettunen, Petronella (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Tsolaki, Magda (author)
- 1st Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece
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- Verhey, Frans R. J. (author)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Alcolea, Daniel (author)
- Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Lleó, Alberto (author)
- Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Peyratout, Gwendoline (author)
- Lausanne University Hospital, Lausanne, Switzerland
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- Tainta, Mikel (author)
- Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Spain
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- Johannsen, Peter (author)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark
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- Freund-Levi, Yvonne, 1956- (author)
- Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
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- Frölich, Lutz (author)
- Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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- Dobricic, Valerija (author)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
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- Frisoni, Giovanni B. (author)
- Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
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- Molinuevo, José Luis (author)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Popp, Julius (author)
- Old Age Psychiatry, Department of Psychiatry, University Hospital Lausanne, Lausanne, Switzerland; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland
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- Martinez-Lage, Pablo (author)
- Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain
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- Bertram, Lars (author)
- Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Streffer, Johannes (author)
- Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
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- Visser, Pieter Jelle (author)
- Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Lovestone, Simon (author)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Psychiatry, University of Oxford, Oxford, UK; Janssen-Cilag UK Ltd., Oxford, UK
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- Proitsi, Petroula (author)
- Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
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- Legido-Quigley, Cristina (author)
- Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center, Gentofte, Denmark
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The European Medical Information Framework Consortium, - (contributor)
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(creator_code:org_t)
- 2021-11-03
- 2021
- English.
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In: Biomedicines. - : MDPI. - 2227-9059. ; 9:11
- Related links:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- BACKGROUND: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives.METHODS: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites' discriminatory performance in AD.RESULTS: In females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (area under curve (AUC) = 0.83, standard error (SE) = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046).CONCLUSIONS: metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- blood
- metabolic pathway
- metabolomics
- sex
- tryptophan betaine
- vanillylmandelate
- Alzheimer’s disease
- blood
- metabolic pathway
- metabolomics
- sex
- tryptophan betaine
- vanillylmandelate
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Xu, Jin
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Green, Rebecca
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Kim, Min
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Lord, Jodie
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Ebshiana, Amera
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Westwood, Sarah
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show more...
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Baird, Alison L.
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Nevado-Holgado, ...
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Shi, Liu
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Hye, Abdul
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Snowden, Stuart ...
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Bos, Isabelle
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Vos, Stephanie J ...
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Vandenberghe, Ri ...
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Teunissen, Charl ...
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Kate, Mara Ten
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Scheltens, Phili ...
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Gabel, Silvy
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Meersmans, Karen
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Blin, Olivier
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Richardson, Jill
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De Roeck, Ellen ...
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Engelborghs, Seb ...
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Sleegers, Kriste ...
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Bordet, Régis
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Rami, Lorena
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans R. ...
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Alcolea, Daniel
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Lleó, Alberto
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Peyratout, Gwend ...
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Tainta, Mikel
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Frisoni, Giovann ...
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Molinuevo, José ...
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Wallin, Anders, ...
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Popp, Julius
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Martinez-Lage, P ...
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Bertram, Lars
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Visser, Pieter J ...
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Lovestone, Simon
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Proitsi, Petroul ...
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Legido-Quigley, ...
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The European Med ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Biomedicines
- By the university
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Örebro University
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Karolinska Institutet
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University of Gothenburg