SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Nevado Holgado Alejo) srt2:(2021);pers:(Scheltens Philip)"

Sökning: WFRF:(Nevado Holgado Alejo) > (2021) > Scheltens Philip

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Shi, Liu, et al. (författare)
  • Replication study of plasma proteins relating to Alzheimer's pathology.
  • 2021
  • Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279 .- 1552-5260. ; 17:9, s. 1452-1464
  • Tidskriftsartikel (refereegranskat)abstract
    • This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.
  •  
2.
  • Xu, Jin, et al. (författare)
  • Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort
  • 2021
  • Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 9:11
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives.METHODS: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites' discriminatory performance in AD.RESULTS: In females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (area under curve (AUC) = 0.83, standard error (SE) = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046).CONCLUSIONS: metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Blennow, Kaj, 1958 (2)
Zetterberg, Henrik, ... (2)
Tsolaki, Magda (2)
Kettunen, Petronella (2)
Vandenberghe, Rik (2)
Scheltens, Phili... (2)Ta bort avgränsningen
visa fler...
Teunissen, Charlotte ... (2)
Martínez-Lage, Pablo (2)
Lleó, Alberto (2)
Rami, Lorena (2)
Frisoni, Giovanni B. (2)
Engelborghs, Sebasti ... (2)
Hye, Abdul (2)
Nevado-Holgado, Alej ... (2)
Lovestone, Simon (2)
Visser, Pieter Jelle (2)
Freund-Levi, Yvonne, ... (2)
Bertram, Lars (2)
Sleegers, Kristel (2)
Frölich, Lutz (2)
Bos, Isabelle (2)
Vos, Stephanie J. B. (2)
Johannsen, Peter (2)
Popp, Julius (2)
Bordet, Régis (2)
Legido-Quigley, Cris ... (2)
Dobricic, Valerija (2)
Gabel, Silvy (2)
Blin, Olivier (2)
Peyratout, Gwendolin ... (2)
Tainta, Mikel (2)
Streffer, Johannes (2)
Westwood, Sarah (2)
Wallin, Anders, 1950 (1)
Barkhof, Frederik (1)
Molinuevo, José Luis (1)
Ashton, Nicholas J. (1)
Alcolea, Daniel (1)
Molinuevo, José L (1)
Wallin, Anders (1)
Lill, Christina M (1)
De Roeck, Ellen Elis ... (1)
Andreasson, Ulf (1)
Verhey, Frans (1)
Richardson, Jill C (1)
Verhey, Frans R. J. (1)
Kim, Min (1)
Proitsi, Petroula (1)
Kolb, Hartmuth C (1)
Sala, Isabel (1)
visa färre...
Lärosäte
Göteborgs universitet (2)
Örebro universitet (2)
Karolinska Institutet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
Naturvetenskap (1)
År
2021 (2)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy