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Heparanase from tri...
Heparanase from triple-negative breast cancer and platelets acts as an enhancer of metastasis
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- Yang, Wen-Jing (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Zhang, Gan-Lin (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Cao, Ke-Xin (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Liu, Xiao-Ni (författare)
- Capital Med Univ, Beijing Youan Hosp, Beijing Inst Hepatol, Beijing 100069, Peoples R China.
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- Wang, Xiao-Min (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Yu, Ming-Wei (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Li, Jin-Ping (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Yang, Guo-Wang (författare)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China Capital Med Univ, Beijing Youan Hosp, Beijing Inst Hepatol, Beijing 100069, Peoples R China. (creator_code:org_t)
- 2020-08-27
- 2020
- Engelska.
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Ingår i: International Journal of Oncology. - : SPANDIDOS PUBL LTD. - 1019-6439 .- 1791-2423. ; 57:4, s. 890-904
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Triple-negative breast cancer (TNBC), which is characterized by inherently aggressive behavior and lack of recognized molecular targets for therapy, poses a serious threat to women's health worldwide. However, targeted treatments have yet to be made available. A crosstalk between tumor cells and platelets (PLT) contributing to growth, angiogenesis and metastasis has been reported in numerous cancers. Heparanase (Hpa), the only mammalian endoglycosidase that cleaves heparan sulfate, has been demonstrated to contribute to the growth, angiogenesis and metastasis of numerous cancers. Hypoxia affects the growth, angiogenesis and metastasis of nearly all solid tumors, and the ability of Hpa to promote invasion is enhanced in hypoxia. However, whether Hpa can strengthen the crosstalk between tumor cells and PLT, and whether enhancing the biological function of Hpa in TNBC promotes malignant progression, have yet to be fully elucidated. The present study, based on bioinformatics analysis and experimental studies in vivo and in vitro, demonstrated that Hpa enhanced the crosstalk between TNBC cells and PLT to increase the supply of oxygen and nutrients, while also conferring tolerance of TNBC cells to oxygen and nutrient shortage, both of which are important for overcoming the stress of hypoxia and nutritional deprivation in the tumor microenvironment, thereby promoting malignant progression, including growth, angiogenesis and metastasis in TNBC. In addition, the hypoxia-inducible factor-1a (HIF-1a)/vascular endothelial growth factor-a (VEGF- a)/phosphorylated protein kinase B (p-)Akt axis may be the key pathway involved in the effects of Hpa on the biological processes mentioned above. Therefore, improving local hypoxia, anti-Hpa treatment and inhibiting PLT activation may improve the prognosis of TNBC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- triple-negative breast cancer
- platelets
- heparanase
- hypoxia
- metastasis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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