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Strategy for improv...
Strategy for improved characterization of human metabolic phenotypes using a COmbined Multi-block Principal components Analysis with Statistical Spectroscopy (COMPASS)
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- Loo, Ruey Leng (författare)
- Centre for Computational and Systems Medicine, WA, Perth, Australia; The Australian National Phenome Centre, Health Futures Institute, Murdoch University, WA, Perth, Australia
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- Chan, Queenie (författare)
- MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
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- Antti, Henrik, 1970- (författare)
- Umeå universitet,Kemiska institutionen
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- Li, Jia V (författare)
- Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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- Ashrafian, H. (författare)
- Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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- Elliott, Paul (författare)
- MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom
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- Stamler, Jeremiah (författare)
- Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, IL, Chicago, United States
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- Nicholson, Jeremy K (författare)
- Centre for Computational and Systems Medicine, WA, Perth, Australia; The Australian National Phenome Centre, Health Futures Institute, Murdoch University, WA, Perth, Australia
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- Holmes, Elaine (författare)
- Centre for Computational and Systems Medicine, WA, Perth, Australia; The Australian National Phenome Centre, Health Futures Institute, Murdoch University, WA, Perth, Australia; Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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- Wist, Julien (författare)
- Chemistry Department, Universidad Del Valle, Cali, Colombia
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(creator_code:org_t)
- 2020-07-21
- 2020
- Engelska.
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Ingår i: Bioinformatics. - : Oxford University Press. - 1367-4803 .- 1367-4811 .- 1460-2059. ; 36:21, s. 5229-5236
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Motivation: Large-scale population omics data can provide insight into associations between gene-environment interactions and disease. However, existing dimension reduction modelling techniques are often inefficient for extracting detailed information from these complex datasets.Results: Here, we present an interactive software pipeline for exploratory analyses of population-based nuclear magnetic resonance spectral data using a COmbined Multi-block Principal components Analysis with Statistical Spectroscopy (COMPASS) within the R-library hastaLaVista framework. Principal component analysis models are generated for a sequential series of spectral regions (blocks) to provide more granular detail defining sub-populations within the dataset. Molecular identification of key differentiating signals is subsequently achieved by implementing Statistical TOtal Correlation SpectroscopY on the full spectral data to define feature patterns. Finally, the distributions of cross-correlation of the reference patterns across the spectral dataset are used to provide population statistics for identifying underlying features arising from drug intake, latent diseases and diet. The COMPASS method thus provides an efficient semi-automated approach for screening population datasets.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
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Loo, Ruey Leng
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Chan, Queenie
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Antti, Henrik, 1 ...
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Li, Jia V
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Ashrafian, H.
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Elliott, Paul
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Stamler, Jeremia ...
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Nicholson, Jerem ...
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Holmes, Elaine
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Wist, Julien
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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Bioinformatics
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Umeå universitet