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Vaccination against...
Vaccination against tick-borne encephalitis (TBE) after autologous and allogeneic stem cell transplantation
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- Einarsdottir, Sigrun (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Nicklasson, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Veje, Malin (author)
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Studahl, Marie, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Lisak, Mikael (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Olsson, M. (author)
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Johansson, B. (author)
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Andreasson, B. (author)
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- Piauger, Bénédicte (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Roth, Anette (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Friman, Vanda, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Ljungman, P. (author)
- Karolinska Institutet
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 39:7, s. 1035-1038
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Abstract
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- Introduction: Our aim was to assess response and side effects of 4 doses of TBE vaccine to patients (pts) after allo- and autologous stem cell transplantation (SCT). PATIENTS: Included were 104 pts with leukaemia, myeloma and lymphoma, median age 61 yrs. METHODS: Vaccine (FSME-Immun (R)) was given at 9, 10, 12, and 21 months post-transplant. Serum samples were obtained before and after vaccinations. Healthy controls (n = 27) received 3 vaccinations. Assessments of TBE specific IgG antibodies were performed by Enzygnost anti-TBE ELISA test (Siemens, Sweden). Results: Antibody levels (>12 U/mL; "seropositivity") were seen in 77% and 80% of pts after allo- and autoSCT; IgG levels; 89 vs 94 U/mL. Ongoing chronic GvHD and immunosuppression (n = 29) was associated with sero-negativity in the last sample (p = 0.007). All controls (n = 27) developed protective antibody levels. Conclusions: TBE vaccination was safe, and 4 doses starting 9 months post-SCT, induced seropositivity in a vast majority of pts. (C) 2021 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Immunology
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vaccine
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- By the author/editor
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Einarsdottir, Si ...
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Nicklasson, Mali ...
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Veje, Malin
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Bergström, Tomas ...
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Studahl, Marie, ...
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Lisak, Mikael
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Olsson, M.
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Johansson, B.
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Andreasson, B.
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Piauger, Bénédic ...
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Roth, Anette
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Friman, Vanda, 1 ...
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Ljungman, P.
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Brune, Mats, 195 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Vaccine
- By the university
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University of Gothenburg
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Karolinska Institutet