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Multiple Endocrine Neoplasia Type 1 and the Pancreas : Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement

Niederle, Bruno (author)
Med Univ Vienna, Dept Surg, Wahringer Gurtel 18-20, AT-1090 Vienna, Austria.
Selberherr, Andreas (author)
Med Univ Vienna, Dept Surg, Wahringer Gurtel 18-20, AT-1090 Vienna, Austria.
Bartsch, Detlef K. (author)
Philipps Univ Marburg, Dept Visceral Thorac & Vasc Surg, Marburg, Germany.
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Brandi, Maria L. (author)
Fdn FIRMO, Firmo Lab, RMO, Florence, Italy.;Univ Florence, Florence, Italy.
Doherty, Gerard M. (author)
Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA USA.
Falconi, Massimo (author)
Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreat Surg, Milan, Italy.
Goudet, Pierre (author)
Ctr Hosp Univ Francois Mitterand, Serv Chirurg Viscerale & Endocrinienne, Dijon, France.
Halfdanarson, Thorvardur R. (author)
Mayo Clin, Dept Med Oncol, Canc Ctr, Rochester, MN USA.
Ito, Tetsuhide (author)
Int Univ Hlth & Welf, Fukuoka Sanno Hosp, Neuroendocrine Tumor Ctr, Sawara Ku, Fukuoka, Japan.;Int Univ Hlth & Welf, Grad Sch Med Sci, Dept Gastroenterol, Sawara Ku, Fukuoka, Japan.
Jensen, Robert T. (author)
NIDDK, NIH, Bethesda, MD USA.
Larghi, Alberto (author)
Catholic Univ, Fdn Policlin A Gemelli IRCCS, Digest Endoscopy Unit, Rome, Italy.;Catholic Univ, Ctr Endoscop Res Therapeut & Training, Rome, Italy.
Lee, Lingaku (author)
NIDDK, NIH, Bethesda, MD USA.
Öberg, Kjell, 1946- (author)
Uppsala universitet,Endokrin tumörbiologi
Pavel, Marianne (author)
Univ Clin Erlangen, Dept Med 1, Endocrinol & Diabetol, Erlangen, Germany.
Perren, Aurel (author)
Univ Bern, Inst Pathol, Bern, Switzerland.
Sadowski, Samira M. (author)
NCI, Surg Oncol Program, NIH, Bethesda, MD USA.
Tonelli, Francesco (author)
Univ Florence, Dept Surg & Translat Med, Florence, Italy.
Triponez, Frédéric (author)
Univ Hosp Geneva, Thorac & Endocrine Surg, Geneva, Switzerland.
Valk, Gerlof D. (author)
Univ Med Ctr Utrecht, Dept Endocrine Oncol, Utrecht, Netherlands.
O'Toole, Dermot (author)
St James Hosp, Dept Clin Med, Dublin, Ireland.;St Vincents Univ Hosp, Dublin, Ireland.;Trinity Coll Dublin, Dublin, Ireland.
Scott-Coombes, David (author)
Univ Hosp Wales, Dept Endocrine Surg, Cardiff, Wales.
Thakker, Rajesh V. (author)
Univ Oxford, Churchill Hosp, Oxford Ctr Diabet, Acad Endocrine Unit, Oxford, England.
Thompson, Geoffrey B. (author)
Mayo Clin, Dept Gastroenterol & Gen Surg, Sect Endocrine Surg, Rochester, MN USA.
Treglia, Giorgio (author)
Osped Cantonale, Imaging Inst Southern Switzerland, Bellinzona, Switzerland.
Wiedenmann, Bertram (author)
Charite Univ Med Berlin, Dept Gastroenterol & Hepatol, Campus Virchow Klinikum, Berlin, Germany.;Charite Univ Med Berlin, Campus Charite Mitte, Berlin, Germany.
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Med Univ Vienna, Dept Surg, Wahringer Gurtel 18-20, AT-1090 Vienna, Austria Philipps Univ Marburg, Dept Visceral Thorac & Vasc Surg, Marburg, Germany. (creator_code:org_t)
2020-09-24
2021
English.
In: Neuroendocrinology. - : S. Karger. - 0028-3835 .- 1423-0194. ; 111:7, s. 609-630
Related links:
https://www.karger.c...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Multiple endocrine neoplasia type 1
Neuroendocrine pancreatic tumors
Diagnosis
Treatment
Consensus statement

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