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Sökning: WFRF:(Niessner A)

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  • Shah, Sonia, et al. (författare)
  • Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
  • 2020
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723 .- 2041-1723. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
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  • Malengo, A., et al. (författare)
  • Final report on EURAMET project 1395/EURAMET.M.FF-K4.1.2016 : Volume comparison at 20 L
  • 2020
  • Ingår i: Metrologia. - : Institute of Physics Publishing. - 0026-1394 .- 1681-7575. ; 57:1
  • Tidskriftsartikel (refereegranskat)abstract
    • During the EURAMET TC-F annual meeting, held in Boras in 2015, it was agreed to perform the follow up of the CCM.FF-K4.1.2011 organized for the EURAMET NMIs for volume of liquids at 20 L. The transfer standard was a 20 L pipette supplied by CENAM. The participants of this comparison also involved in the comparison CCM.FF-K4.1.2011 were: CENAM, INRIM, IPQ, RISE and VSL, in total there were twenty-one participants. The comparison was organized in two petals, INIRM perform three measurements, at the beginning, after the first petal and at the end of the circulation. The comparison measurements started in April 2016 and ended in October 2017. It should be noted that most of the participants (thirteen) declared an expanded uncertainty less than 0,005 %. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA). 
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  • Baumgardner, D., et al. (författare)
  • Soot reference materials for instrument calibration and intercomparisons: a workshop summary with recommendations
  • 2012
  • Ingår i: Atmospheric Measurement Techniques. - : Copernicus Gesellschaft mbH. - 1867-1381. ; 5:8, s. 1869-1887
  • Tidskriftsartikel (refereegranskat)abstract
    • Soot, which is produced from biomass burning and the incomplete combustion of fossil and biomass fuels, has been linked to regional and global climate change and to negative health problems. Scientists measure the properties of soot using a variety of methods in order to quantify source emissions and understand its atmospheric chemistry, reactivity under emission conditions, interaction with solar radiation, influence on clouds, and health impacts. A major obstacle currently limiting progress is the absence of established standards or reference materials for calibrating the many instruments used to measure the various properties of soot. The current state of availability and practicability of soot standard reference materials (SRMs) was reviewed by a group of 50 international experts during a workshop in June of 2011. The workshop was convened to summarize the current knowledge on soot measurement techniques, identify the measurement uncertainties and limitations related to the lack of soot SRMs, and identify attributes of SRMs that, if developed, would reduce measurement uncertainties. The workshop established that suitable SRMs are available for calibrating some, but not all, measurement methods. The community of users of the single-particle soot-photometer (SP2), an instrument using laser-induced incandescence, identified a suitable SRM, fullerene soot, but users of instruments that measure light absorption by soot collected on filters did not. Similarly, those who use thermal optical analysis (TOA) to analyze the organic and elemental carbon components of soot were not satisfied with current SRMs. The workshop, and subsequent, interactive discussions, produced a number of recommendations for the development of new SRMs, and their implementation, that would be suitable for the different soot measurement methods.
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  • Resultat 1-10 av 26
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