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- Horvatovich, Peter, et al.
(författare)
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Quest for Missing Proteins : Update 2015 on Chromosome-Centric Human Proteome Project
- 2015
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 14:9, s. 3415-3431
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wild (http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.
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- Nilsson, Emma A
(författare)
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FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. FOXC2 encodes a forkhead transcription factor, which was identified as a key regulator of adipocyte metabolism in mice overexpressing FOXC2 in adipose tissue. The exact function of FOXC2 in humans remains unknown. FOXC2 mRNA levels in both visceral fat and skeletal muscle correlated with measures of insulin sensitivity and FOXC2 mRNA expression was significantly higher in visceral compared to subcutaneous fat in humans. FOXC2 mRNA levels were upregulated in response to insulin in cultured human adipocytes. A common variant in the 5' untranslated region of the gene (C-512T) was identified. The C-allele was associated with higher triglyceride levels and higher HOMA-IR indeces in female sibling pairs as well as with obesity, and the Metabolic Syndrome in males. However, no association was found between this polymorphism and type 2 diabetes. CAPN10, encoding the cysteine protease calpain-10, was the first type 2 diabetes susceptibility gene discovered by a genome-wide scan and positional cloning. We found that CAPN10 mRNA expression is a heritable trait. Furthermore, a polymorphism in the gene (SNP-43) was associated with reduced CAPN10 mRNA levels in both subcutaneous fat and skeletal muscle. Subjects with normal glucose tolerance, but not subjects with impaired glucose tolerance, upregulated CAPN10 mRNA levels in response to fat during a hyperinsulinemic euglycemic clamp. These results suggest that the C-allele at FOXC2 C-512T and low FOXC2 mRNA expression predispose individuals to obesity and insulin resistance but not to type 2 diabetes. CAPN10 mRNA expression is a heritable trait and influenced by variation at SNP-43. Although CAPN10 SNP-43 is not associated with obesity, low CAPN10 mRNA expression, or inability to upregulate CAPN10 mRNA levels in response to elevated FFA and insulin, may predispose towards insulin resistance and type 2 diabetes.
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- Nilsson, Lena A., 1947-, et al.
(författare)
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Ett utvidgat hälsobegrepp i förskolan
- 2022. - 1.
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Ingår i: En förskola för alla. - Stockholm : Liber. - 9789147141487 ; , s. 87-100
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Bokens sammanfattning:Den utbildning och fostran som barn möter under den första delen av livet har betydelse för deras utveckling, lärande och framtida livsvillkor. Förskolan är det första steget i utbildningen och därför är dess roll viktig. I förskolans uppdrag framgår att alla barn har rätt till gemenskap. Barnen har också rätt till en undervisning som är organiserad utifrån deras behov. I den här antologin är därför frågor om alla barns inflytande, delaktighet och perspektiv tongivande. Boken tar upp specialpedagogik, inkludering och likvärdighet och utgår från ett historiskt och samtida sammanhang. Specialpedagogik och specialpedagogisk verksamhet problematiseras samtidigt som relevanta områden som rör förskolan presenteras.
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- Nilsson, Lena A., 1947-, et al.
(författare)
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Forskningsmetoder för samverkansforskning
- 2019
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Ingår i: Samverkansforskning. - Stockholm : Liber. - 9789147127009 ; , s. 115-120
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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- Nilsson, Lena A., 1947-, et al.
(författare)
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Är samverkansforskning riktig forskning?
- 2019
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Ingår i: Samverkansforskning. - Stockholm : Liber. - 9789147127009 ; , s. 29-32
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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