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Träfflista för sökning "WFRF:(Nilsson Emma A) ;hsvcat:1;hsvcat:3"

Search: WFRF:(Nilsson Emma A) > Natural sciences > Medical and Health Sciences

  • Result 1-4 of 4
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  • 2019
  • Journal article (peer-reviewed)
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  • Garvanska, Dimitriya H., et al. (author)
  • The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
  • 2024
  • In: EMBO Reports. - : Springer Nature. - 1469-221X .- 1469-3178. ; 25:2, s. 902-926
  • Journal article (peer-reviewed)abstract
    • Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these interactions. Here, we uncover a novel interaction between the viral NSP3 protein and the fragile X mental retardation proteins (FMRPs: FMR1, FXR1-2). SARS-CoV-2 NSP3 mutant viruses preventing FMRP binding have attenuated replication in vitro and reduced levels of viral antigen in lungs during the early stages of infection. We show that a unique peptide motif in NSP3 binds directly to the two central KH domains of FMRPs and that this interaction is disrupted by the I304N mutation found in a patient with fragile X syndrome. NSP3 binding to FMRPs disrupts their interaction with the stress granule component UBAP2L through direct competition with a peptide motif in UBAP2L to prevent FMRP incorporation into stress granules. Collectively, our results provide novel insight into how SARS-CoV-2 hijacks host cell proteins and provides molecular insight into the possible underlying molecular defects in fragile X syndrome.
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  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (4)
Author/Editor
Zhang, Yan (1)
Korhonen, Laura (1)
Lindholm, Dan (1)
Kelly, Daniel (1)
Vertessy, Beata G. (1)
Bengtsson-Palme, Joh ... (1)
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Nilsson, Emma (1)
Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
Wang, Mei (1)
Wang, Xin (1)
Liu, Yang (1)
Kumar, Rakesh (1)
Wang, Dong (1)
Liu, Fang (1)
Li, Ke (1)
Liu, Ke (1)
Zhang, Yang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Nàgy, Péter (1)
Kahan, Thomas (1)
Kominami, Eiki (1)
van der Goot, F. Gis ... (1)
Lindblad-Toh, Kersti ... (1)
Sörelius, Karl, 1981 ... (1)
Bonaldo, Paolo (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Adams, Christopher M (1)
Minucci, Saverio (1)
Vellenga, Edo (1)
Backman, Lars (1)
Yan, Hong (1)
Swärd, Karl (1)
Nilsson, Per (1)
Pippel, Martin (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
De Milito, Angelo (1)
Zhang, Wei (1)
Zhang, Jian (1)
Hammerschmidt, Sven (1)
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University
Umeå University (2)
Uppsala University (2)
Stockholm University (2)
Lund University (2)
Karolinska Institutet (2)
University of Gothenburg (1)
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Halmstad University (1)
Linköping University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
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Language
English (4)
Research subject (UKÄ/SCB)
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