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Folate, vitamin B12...
Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake.
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- Van Guelpen, Bethany (author)
- Umeå universitet,Patologi
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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- Johansson, Ingegerd (author)
- Umeå universitet,Kariologi
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- Stegmayr, Birgitta (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Nilsson, Torbjörn K (author)
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- Weinehall, Lars (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap
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- Witthöft, Cornelia M. (author)
- Sveriges lantbruksuniversitet, Uppsala
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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- Winkvist, Anna, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk näringslära,Institute of Internal Medicine, Dept of Clinical Nutrition
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Stroke; a journal of cerebral circulation. - 1524-4628 .- 0039-2499. ; 36:7, s. 1426-31
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND AND PURPOSE: Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B12, independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and dietary intake levels of folate and vitamin B12 to risk of stroke, taking into consideration plasma homocysteine concentrations and methylenetetrahydrofolate reductase polymorphisms. METHODS: Subjects were 334 ischemic and 62 hemorrhagic stroke cases and matched double referents from the population-based Northern Sweden Health and Disease Cohort. RESULTS: Plasma folate was statistically significantly associated with risk of hemorrhagic stroke in an inverse linear manner, both in univariate analysis and after adjustment for conventional risk factors including hypertension (odds ratio [OR] for highest versus lowest quartile 0.21 (95% confidence interval [CI], 0.06 to 0.71; P for trend=0.008)). Risk estimates were attenuated by inclusion of homocysteine in the model (OR, 0.34; 95% CI, 0.08 to 1.40; P for trend=0.088). A similar pattern was observed for increasing folate intake (multivariate OR, 0.07; 95% CI, 0.01 to 0.55; P for trend=0.031 without homocysteine, and OR, 0.16, 95% CI, 0.02 to 1.23; P for trend=0.118 with homocysteine in the analysis). We found little evidence of an association between plasma or dietary folate and risk of ischemic stroke. Neither plasma nor dietary vitamin B12 was associated with risk of either stroke subtype. CONCLUSIONS: The results of this study suggest a protective role for folate, possibly in addition to its effects on homocysteine status, in hemorrhagic but not ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Keyword
- Adult
- Aged
- Brain Ischemia
- etiology
- pathology
- Case-Control Studies
- Cerebrovascular Accident
- etiology
- pathology
- Cohort Studies
- Diet
- Female
- Folic Acid
- blood
- pharmacology
- Hemorrhage
- blood
- Homocysteine
- blood
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- genetics
- Middle Aged
- Multivariate Analysis
- Nutritional Status
- Odds Ratio
- Polymorphism
- Genetic
- Prospective Studies
- Registries
- Risk
- Sweden
- Vitamin B 12
- pharmacology
- Adult
- Natural Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Van Guelpen, Bet ...
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Hultdin, Johan
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Johansson, Ingeg ...
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Stegmayr, Birgit ...
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Hallmans, Göran
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Nilsson, Torbjör ...
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Weinehall, Lars
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Witthöft, Cornel ...
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Palmqvist, Richa ...
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Winkvist, Anna, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Health Care Serv ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
- Articles in the publication
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Stroke; a journa ...
- By the university
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University of Gothenburg
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Umeå University
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Linnaeus University