| 1. |
- Bock, O., et al.
(author)
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Use of GNSS Tropospheric Products for Climate Monitoring (Working Group 3)
- 2020
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In: Advanced GNSS Tropospheric Products for Monitoring Severe Weather Events and Climate. - Cham : Springer International Publishing. - 9783030139001 ; , s. 267-402
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Book chapter (other academic/artistic)abstract
- There has been growing interest in recent years in the use of homogeneously reprocessed ground-based GNSS, VLBI, and DORIS measurements for climate applications. Existing datasets are reviewed and the sensitivity of tropospheric estimates to the processing details is discussed. The uncertainty in the derived IWV estimates and linear trends is around 1 kg m^2 RMS and ± 0.3 kg m^2 per decade, respectively. Standardized methods for ZTD outlier detection and IWV conversion are proposed. The homogeneity of final time series is limited however by changes in the stations equipment and environment. Various homogenization algorithms have been evaluated based on a synthetic benchmark dataset. The uncertainty of trends estimated from the homogenized times series is estimated to ±0.5 kg m^2 per decade. Reprocessed GNSS IWV data are analysed along with satellites data, reanalyses and global and regional climate model simulations. A selection of global and regional reprocessed GNSS datasets and ERA-interim reanalysis are made available through the GOP-TropDB tropospheric database and online service. A new tropo SINEX format, providing new features and simplifications, was developed and it is going to be adopted by all the IAG services.
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| 2. |
- Nilsson, Peter M., et al.
(author)
-
Early Vascular Aging in the Young : Influence of Birth Weight and Prematurity
- 2015
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In: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection. - 9780128013878 - 9780128016763 ; , s. 129-136
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Book chapter (peer-reviewed)abstract
- Longitudinal data from cohort studies show that early life factors such as low birth weight are associated with the development of hypertension, coronary heart disease, and type 2 diabetes in adulthood. Moreover, the majority of published studies concur that blood pressure is higher in adolescents and young adults with a history of low birth weight. Although the precise mechanisms linking early life factors with increased future cardiovascular risk are unclear, the architecture of the vascular system is programmed in utero and the majority of elastin, the major structural component underlying arterial wall elasticity, is synthesized and deposited during this time. Therefore, the arterial system has been a major focus of investigations aimed toward improving our understanding of the natural history of hypertension and future cardiovascular risk. A number of studies have now described properties relating to arterial structure and function in children, adolescents, and young adults, with a history of low birth weight, due to being either small for gestational age or premature. While the combination of prematurity and intrauterine growth retardation resulting in a small for gestational age phenotype appears to be associated with the most marked impairments in vascular structure and function, the small for gestational age phenotype, followed by a rapid "catch-up" growth also appears harmful. Further studies are needed to understand the long-term consequences of cardiovascular health of being born under adverse conditions, especially when post-natal growth trajectories are taken into account.
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| 3. |
- Frej, Fyhrquist, et al.
(author)
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Telomere Biology and Vascular Aging
- 2015
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In: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection. - 9780128013878 - 9780128016763 ; , s. 201-211
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Book chapter (peer-reviewed)abstract
- Telomeres form the end segment of the DNA helix and shorten with every cell division until getting so short that the cell stops dividing and will undergo programmed cell death (apoptosis). Research has supported the view that telomere length could be regarded as a marker of biological aging, even if methodological problems could interfere with the interpretation of telomere length in cross-sectional studies when causality cannot be proven. Ideally the telomere attrition rate should be calculated based on repeated measurements during follow-up. So far, epidemiological studies have supported the role of short telomeres being predictive of coronary heart disease (CHD) events but not stroke, based on meta-analysis. A genetic risk score based on several genetic markers of telomere biology is associated with CHD risk, which proves that a true causal and unconfounded relationship may exist. Future intervention studies will hopefully reveal whether telomere length is possible to influence by lifestyle improvements or drug therapy in randomized, controlled studies.
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| 4. |
- Landegren, U., et al.
(author)
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Detecting genes with ligases.
- 1996
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In: Methods: a companion to Methods in Enzymology.. ; , s. 84-
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Book chapter (other academic/artistic)
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| 5. |
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| 6. |
- Landegren, U., et al.
(author)
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Ligase-mediated gene detection .
- 1996
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In: Encyclopedia of molecular biology: fundamentals and applications.. - : VCH Publisher, Weinheim. ; , s. 391-
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Book chapter (other academic/artistic)
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| 7. |
- Nilsson, Astrid M. H., et al.
(author)
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Preface
- 2017
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In: Humanitas : Festskrift till Arne Jönsson - Festskrift till Arne Jönsson. - 9789170612442 ; , s. 15-18
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Book chapter (other academic/artistic)
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| 8. |
- Nilsson, Peter M., et al.
(author)
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Preface
- 2015
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In: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection. - 9780128013878 - 9780128016763
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Book chapter (other academic/artistic)
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| 9. |
- Nilsson, Peter M., et al.
(author)
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Preface
- 2015
-
In: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection. - 9780128013878 - 9780128016763
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Book chapter (other academic/artistic)
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| 10. |
- Scuteri, Angelo, et al.
(author)
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Aging Population : Challenges and Opportunities in a Life Course Perspective
- 2015
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In: Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection. - 9780128013878 - 9780128016763 ; , s. 17-20
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Book chapter (peer-reviewed)abstract
- In most Western countries the mean longevity for both men and women has increased dramatically over the past 100 years. This was first attributable to a reduction in perinatal and child mortality when deliveries became safer and conditions for children more healthy, such as better nutrition. In recent decades another trend is visible, that is, a reduction of the negative impact of chronic disease in midlife and a postponement of life-threatening medical conditions until old age. This is why the mean life expectancy now reaches around 80 years in many developed countries, even if there is still a substantial gap to the shorter life span of many people living in developing countries, but also in the former Soviet Union. To better understand this demographic transition we need to consider the influence of environmental and social factors, as our genetic setup will not change in the shorter time perspective (centuries). On the other hand we also need a deeper understanding of the influence of early life programming on adult health and longevity to fully grasp the shifting demography of human populations, in a life course perspective.
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