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- Gorniak, R. J. T., et al.
(author)
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Evaluation of a semiautomatic 3D fusion technique applied to molecular imaging and MRI brain/frame volume data sets
- 2003
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In: Journal of medical systems. - 0148-5598 .- 1573-689X. ; 27:2, s. 141-156
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Journal article (peer-reviewed)abstract
- A generally applicable {3D} fusion method was evaluated using molecular imaging and {MRI} volumetric data sets from 15 brain tumor patients with stereotactic frames attached to their skull. Point pairs, placed on the frame only, were chosen, polynomial warping coefficients were generated to map voxels from one coordinate space to the other. The {MRI} frame was considered the reference structure and the standard for "correct" registration. An {ANOVA} test (p {\textgreater} 0.05) confirmed the point pair choice to be consistent. The 95\% confidence interval for the t-test showed the measured distance difference between the registered volumes was within one {MRI} voxel. A further experiment was conducted to independently evaluate the brain registration based on testing for consistency of randomly selected interior/exterior points. A t-test result (p {\textless} 0.05) showed that the consistency (i.e., both interior or both exterior) before and after volume registration were significantly different. This fusion method may be a viable alternative when other methods fail.
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| 5. |
- Kimiaei, S., et al.
(author)
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Evaluation of polynomial image deformation for matching of 3D-abdominal MR-images using anatomical landmarks and for atlas construction
- 1998
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In: 1998 IEEE Nuclear Science Symposium Conference Record. 1998. - Toronto, Ont., Canada : IEEE. ; , s. 2050-2052
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Conference paper (peer-reviewed)abstract
- The aim of this study is to compare and evaluate the potential usability of linear and non-linear (polynomial) 3D-warping for constructing an atlas by matching abdominal MR-images from a number of different individuals using manually picked anatomical landmarks. The significance of this study lies in the fact that it illustrates the potential to use polynomial matching at a local or organ level. This is a necessary requirement for constructing an atlas and for fine intra-patient image matching and fusion. Finally 3D-image warping using anatomical landmark for inter-patient intra-modality image co-registration and fusion was found to be a very powerful and robust method. Additionally it can be used for intra-patient inter-modality image matching.
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| 6. |
- Kimiaei, Sharok, et al.
(author)
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Evaluation of polynomial image deformation using anatomical landmarks for matching of 3D-abdominal MR-images and for atlas construction
- 1999
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In: IEEE TRANSACTIONS ON NUCLEAR SCIENCE. - : IEEE. - 0018-9499. ; 46:4, s. 1110-1113
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Journal article (peer-reviewed)abstract
- While a variety of different deformation algorithms have been implemented for matching of skull, few attempts in matching areas in abdomen have been reported. In this study the authors evaluate the usability of first and second order polynomial 3D-warping for this purpose. They match abdominal MR-images from different individuals using manually picked anatomical landmarks. Generation of transformation coefficients was done through a linear regression technique that employs a least square fit using the reference landmarks. The landmarks were picked in a predefined order, well spread over the entire data set, by a radiologist. The image resampling was done using linear interpolation and the evaluation was performed visually as well as by calculating the cross correlation and the normalized least squared error between the original image and the transformed image. The authors' preliminary results reveal that the second order polynomial transformation using landmarks is a robust and efficient method. It is also superior to the second order one, for image deformation in the abdominal region and it may be used in atlas generation as well as in multimodality image co-registration and fusion.
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| 7. |
- Maguire Jr., Gerald Q., et al.
(author)
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A Digital Radiology Department
- 1982
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In: Medical physics (Lancaster). - 0094-2405. ; 9:4, s. 636-
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Journal article (peer-reviewed)
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| 8. |
- Maguire Jr., Gerald Q., et al.
(author)
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Image Processing Requirements and Distributed Networks in a Digital Imaging Environment
- 1982
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In: Proceedings of Annual Symposium on Computer Application in Medical Care (SCAMC ’82). - : IEEE. ; , s. 923-
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Conference paper (peer-reviewed)abstract
- This paper will discuss a unified digital image distribution and processing system linking various digital image sources through a broadband local area network and a comnon image format. Ultimately, the system allows for viewing and processing of all images produced within the complex, and for viewing stations at any number of convenient locations. The physical handling of storage media at image sources, can be totally eliminated. Complete archiving, file maintenance and large scale processing capabilities are provided by a central file server. This paper presents a concrete proposal for an initial system which has a central archiving facility for permanently storing and selectively viewing computed tomography (CT), nuclear medicine (NM) and ultrasound (US) images. The system proposed can then be slowly expanded to include all the digital images produced by the radiology the department, and ultimately to include all the images by digitizing those produced in an analog fashion.
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| 9. |
- Maguire Jr., Gerald Q., et al.
(author)
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Interface Requirements in Nuclear Medicine-Devices and Systems
- 1982
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In: IEEE Transactions on Nuclear Science. - : IEEE. - 0018-9499 .- 1558-1578. ; 29:4, s. 1280-1290
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Journal article (peer-reviewed)abstract
- Interface designs for three nuclear medicine imaging systems, and computer networking strategies proposed for medical imaging departments are presented. Configurations for two positron emission tomography devices (PET III and ECAT) and a general purpose tomography instrument (the UNICON) are analyzed in terms of specific performance parameters. Interface designs for these machines are contrasted in terms of utilization of standard versus custom modules, cost, and ease of modification, upgrade, and support. The requirements of general purpose systems for medical image analysis, display, and archiving, are considered, and a realizable state of the art system is specified, including a suggested timetable.
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| 10. |
- Moy, Linda, et al.
(author)
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Improving specificity of breast MRI using prone PET and fused MRI and PET 3D volume datasets
- 2007
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In: Journal of Nuclear Medicine. - Reston, Virginia, USA : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 48:4, s. 528-537
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Journal article (peer-reviewed)abstract
- MRI is a sensitive method for detecting invasive breast cancer, but it lacks specificity. To examine the effect of combining PET with MRI on breast lesion characterization, a prototype positioning device was fabricated to allow PET scans to be acquired in the same position as MRI scans-that is, prone. Methods: To test the hypothesis that fusion of 18F-FDG PET and MRI scans improves detection of breast cancer, 23 patients with suspected recurrent or new breast cancer underwent a routine whole-body PET scan, a prone PET scan of the chest, and a routine breast MRJ scan. The attenuation-corrected prone PET and MRI clatasets were registered twice by different operators. The fusion results were judged for quality by visual inspection and statistical analysis. A joint reading of the MRI and PET scans side by side and integrated images was performed by a nuclear medicine physician and a radiologist. Sensitivity and specificity of MRI and combined MRI and PET scans were calculated on the basis of pathology reports or at least 1 y of clinical and radiologic follow-up. Results: All fusions were verified to be well matched using specific anatomic criteria. A total of 45 lesions was assessed. Lesion size range was 0.6 to 10.0 cm. Of the 44 breasts examined, 29 were suspicious for cancer, of which 15 were found to be positive on surgical excision. In lesion-by-lesion analysis, sensitivity and specificity of MRI alone were 92% and 52%, respectively; after MRI and PETfusion, they were 63% and 95%, respectively. The positive predictive value and the negative predictive value for MRI alone were 69% and 85%, respectively; after MRI and PET fusion, they were 94% and 69%, respectively. Conclusion: Acquisition of prone PET scans using the new positioning device permitted acquisition of prone scans suitable for fusion with breast MRI scans. Fused PET and MRI scans increased the specificity of MRI but decreased the sensitivity in this small group of patients. Additional data are needed to confirm the statistical significance of these preliminary findings.
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