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Correlations betwee...
Correlations between the enantio- and regio-selective metabolisms of warfarin
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- Takahashi, Harumi (author)
- Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan.
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- Ohara, Minami (author)
- Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan.
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- Shibata, Soichi (author)
- Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan.
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- Lee, Ming Ta Michael (author)
- Geisinger Hlth Syst, Danville, PA USA.;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
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- Cavallari, Larisa H. (author)
- Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.
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- Nutescu, Edith A. (author)
- Univ Illinois, Dept Pharm Practice, Chicago, IL USA.
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- Scordo, Maria Gabriella (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos
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- Pengo, Vittorio (author)
- Univ Padua, Dept Cardiothorac & Vasc Sci, Padua, Italy.
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- Padrini, Roberto (author)
- Univ Padua, Dept Med DIMED, Padua, Italy.
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- Atsuda, Koichiro (author)
- Kitasato Univ Hosp, Dept Pharm, Sagamihara, Kanagawa, Japan.
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- Matsubara, Hajime (author)
- Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan.
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- Chen, Yuan Tsong (author)
- Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
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- Echizen, Hirotoshi (author)
- Meiji Pharmaceut Univ, Dept Pharmacotherapy, Tokyo, Japan.
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Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan. (creator_code:org_t)
- Future Medicine Ltd, 2017
- 2017
- English.
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In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 18:2, s. 133-142
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: Oral clearances (CLpo) of warfarin enantiomers were estimated in 378 Chinese, Caucasians and African-Americans. The partial metabolic clearances (CLm) for 7-hydroxywarfarin enantiomers were also measured. In addition, CLpo and CLm were determined in a patient on warfarin and rifampicin. Results: Correlations between CLpo for warfarin enantiomers existed across the three populations. In addition, there was a significant correlation between the CLm for 7-hydroxylation of warfarin enantiomers. Under induced conditions by rifampicin, there were significant correlations between the enantio-and regio-selective metabolisms of warfarin. Conclusion: Metabolic activities of CYP2C9, CYP1A2 and CYP3A4 may be regulated by common transcriptional mechanism(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- CYP1A2
- CYP2C9
- CYP3A4
- metabolism
- transcriptional factors
- warfarin enantiomers
Publication and Content Type
- ref (subject category)
- art (subject category)
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Takahashi, Harum ...
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Ohara, Minami
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Shibata, Soichi
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Lee, Ming Ta Mic ...
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Cavallari, Laris ...
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Nutescu, Edith A ...
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Scordo, Maria Ga ...
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Pengo, Vittorio
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Padrini, Roberto
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Atsuda, Koichiro
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Matsubara, Hajim ...
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Chen, Yuan Tsong
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Echizen, Hirotos ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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Pharmacogenomics ...
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Uppsala University