| 1. |
- Bale, S. D., et al.
(författare)
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The FIELDS Instrument Suite for Solar Probe Plus
- 2016
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Ingår i: Space Science Reviews. - : Springer Science and Business Media LLC. - 0038-6308 .- 1572-9672. ; 204:1-4, s. 49-82
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Forskningsöversikt (refereegranskat)abstract
- NASA's Solar Probe Plus (SPP) mission will make the first in situ measurements of the solar corona and the birthplace of the solar wind. The FIELDS instrument suite on SPP will make direct measurements of electric and magnetic fields, the properties of in situ plasma waves, electron density and temperature profiles, and interplanetary radio emissions, amongst other things. Here, we describe the scientific objectives targeted by the SPP/FIELDS instrument, the instrument design itself, and the instrument concept of operations and planned data products.
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| 2. |
- Iwata, S., et al.
(författare)
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Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material'' mattress in a newborn piglet model
- 2009
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Ingår i: Archives of Disease in Childhood. - : BMJ. - 0003-9888 .- 1468-2044. ; 94:5, s. 387-391
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Tidskriftsartikel (refereegranskat)abstract
- Background: Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. Aims/Methods: To assess two low-tech, low-cost cooling devices for use in low-resource settings: (i) commercially available water bottles filled with tepid water (25 degrees C); (ii) a mattress made of phase changing material (PCM) with a melting point of 32 degrees C (PCM works as a heat buffer at this temperature). Eleven anaesthetised newborn piglets were studied following transient hypoxia-ischaemia. The cooling device was applied 2-26 h after hypoxia-ischaemia with a target rectal temperature (T-rectal) of 33-34 degrees C. T-rectal undershoot was adjusted using cotton blankets; the cooling device was renewed when T-rectal rose above 35 degrees C. T-rectal data during cooling were dichotomised (within or without target) to assess: (a) the total period within the target T-rectal range; (b) the stability and fluctuation of T-rectal during cooling. Results: Therapeutic hypothermia was achieved with both water bottles (n=5) and the PCM mattress (n=6). The mean (SD) time to reach target T-rectal was 1.8 (0.5) h with water bottles and 1.9 (0.3) h with PCM. PCM cooling led to a longer period within the target T-rectal range (p<0.01) and more stable cooling (p<0.05). Water bottle cooling required device renewal (in four out of five piglets). Conclusion: Simple, low-tech cooling devices can induce and maintain therapeutic hypothermia effectively in a porcine model of neonatal encephalopathy, although frequent fine tuning by adjusting the number of blankets insulating the piglet was required to maintain a stable temperature. PCM may induce more stable cooling compared with water bottles.
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| 5. |
- Fitzpatrick, G., et al.
(författare)
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Daring to change : Creating a slower more sustainable academic life
- 2018
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Ingår i: Conference on Human Factors in Computing Systems - Proceedings. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450356206 - 9781450356213
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Konferensbidrag (refereegranskat)abstract
- Numerous reports and studies point to increasing performance criteria and workplace stress for academics/researchers. Together with the audience, this panel will explore how we experience this in the HCI community, focussing particularly on what we can do to change this for a slower more sustainable academic culture. The future of good quality HCI research is dependent on happy healthy researchers and reasonable realistic academic processes.
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| 6. |
- Olson, Linus, et al.
(författare)
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Comparison of Three Hypothermic Target Temperatures for the Treatment of Hypoxic Ischemia : MRNA Level Responses of Eight Genes in the Piglet Brain
- 2013
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Ingår i: Translational Stroke Research. - : Springer Science and Business Media LLC. - 1868-4483 .- 1868-601X. ; 4:2, s. 248-257
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Tidskriftsartikel (refereegranskat)abstract
- Hypothermia can reduce neurodevelopmental disabilities in asphyxiated newborn infants. However, the optimal cooling temperature for neuroprotection is not well defined. We studied the effects of transient piglet brain hypoxic ischemia (HI) on transcriptional activity of eight genes and if mRNA level alterations could be counteracted by whole body cooling to 35, 33. 5 or 30 °C. BDNF mRNA was globally upregulated by the insult, and none of the cooling temperatures counteracted this change. In contrast, MANF mRNA was downregulated, and these changes were modestly counteracted in different brain regions by hypothermic treatment at 33. 5 °C, while 30 °C aggravated the MANF mRNA loss. MAP2 mRNA was markedly downregulated in all brain regions except striatum, and cooling to 33. 5 °C modestly counteract this downregulation in the cortex cerebri. There was a tendency for GFAP mRNA levels in core, but not mantle regions to be downregulated and for these changes to be modestly counteracted by cooling to 33. 5 or 35 °C. Cooling to 30 °C caused global GFAP mRNA decrease. HSP70 mRNA tended to become upregulated by HI and to be more pronounced in cortex and CA1 of hippocampus during cooling to 33. 5 °C. We conclude that HI causes alterations of mRNA levels of many genes in superficial and deep piglet brain areas. Some of these changes may be beneficial, others detrimental, and lowering body temperature partly counteracts some, but not all changes. There may be general differences between core and mantle regions, as well as between the different cooling temperatures for protection. Comparing the three studied temperatures, cooling to 33. 5 °C, appears to provide the best cooling temperature compromise.
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| 7. |
- Yaroshenko, V.V., et al.
(författare)
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Characteristics of charged dust inferred from the Cassini RPWS measurements in the vicinity of Enceladus
- 2009
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Ingår i: Planetary and Space Science. - : Elsevier BV. - 0032-0633 .- 1873-5088. ; 57:14-15, s. 1807-1812
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Tidskriftsartikel (refereegranskat)abstract
- The data obtained by the Cassini Radio and Plasma Wave Science (RPWS) instrument during the shallow (17.02.2005) and the steep (14.07.2005) crossings of the E-ring revealed a considerable electron depletion in proximity to Enceladus's orbit (the difference between the ion and electron densities can reach similar to 70 cm(-3)). Assuming that this depletion is a signature of the presence of charged dust particles, the main characteristics of dust down to submicron sized particles are derived. The differential size distribution is found to be well described by a power law with an index mu similar to 5.5-6 for the lower size limit a(min) = 0.03 mu m and mu similar to 7.3-8 for a(min) = 0.1 mu m. The calculated average integral dust number density is weakly affected by values of mu and a(min). For a greater than or similar to 0.1 mu m, both flybys gave the maximum dust density about 0.1-0.3 cm(-3) in the vicinity of Enceladus. Our results imply that the dust structure near Enceladus is characterized by approximately the same vertical length scale of 8000 km and reaches a maximum at the same radial distance (displaced outward of the orbit of Enceladus) as found by Kempf et al. [2008. The E-ring in the vicinity of Enceladus. Spatial distribution and properties of the ring particles. Icarus 193, 420-437], from the dust impact data.
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