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The Analgesic Effec...
The Analgesic Effect of Oxygen in Suspected Acute Myocardial Infarction : A Substudy of the DETO2X-AMI Trial
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- Sparv, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden
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- Hofmann, Robin (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,Karolinska Inst, Sodersjukhuset, Div Cardiol, Dept Clin Sci & Educ, Stockholm, Sweden
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- Gunnarsson, Annika (författare)
- Uppsala University Hospital,Uppsala Univ Hosp, Dept Cardiol, Uppsala, Sweden
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- James, Stefan K, 1964- (författare)
- Uppsala universitet,Uppsala University,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Hedberg, Camilla (författare)
- Ryhov County Hospital, Jönköping,Ryhov Hosp, Dept Internal Med, Div Cardiol, Jonkoping, Sweden
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- Lauermann, Jörg (författare)
- Ryhov County Hospital, Jönköping,Ryhov Hosp, Dept Internal Med, Div Cardiol, Jonkoping, Sweden
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- Torild, Petronella (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden
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- Omerovic, Elmir (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden
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- Bergström, Kristina (författare)
- Gävle Hospital,Gavle Sjukhus, Dept Cardiol, Gavle, Sweden
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- Haugen, Espen (författare)
- Sundsvall Hospital,Sundsvall Reg Hosp, Dept Cardiol, Sundsvall, Sweden
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- Bergström, Camilla (författare)
- Danderyd Hospital,Danderyd Hosp, Dept Cardiol, Stockholm, Sweden
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- Linder, Rikard (författare)
- Karolinska Institutet
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- Borg, Pia (författare)
- Svensk PCI Varmland AB, Karlstad, Sweden
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- Haaga, Urban (författare)
- Karlstad Hospital,Cent Hosp Karlstad, Dept Cardiol, Karlstad, Sweden
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- Olsson, Anneli (författare)
- Skåne University Hospital,Skane Univ Hosp, Dept Cardiol, Lund, Sweden
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- Böving, Elin (författare)
- Stockholm South General Hospital,Soder Sjukhuset, Dept Cardiol, Stockholm, Sweden
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- Östlund, Ollie (författare)
- Uppsala universitet,Uppsala University,Uppsala kliniska forskningscentrum (UCR)
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- Rylance, Rebecca (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden
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- Witt, Nils (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,Karolinska Inst, Sodersjukhuset, Div Cardiol, Dept Clin Sci & Educ, Stockholm, Sweden
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden
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James, SJ (författare)
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(creator_code:org_t)
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- Elsevier BV, 2018
- 2018
- Engelska 8 s.
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Ingår i: JACC: Cardiovascular Interventions. - : Elsevier BV. - 1936-8798 .- 1876-7605. ; 39, s. 546-546
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: In this substudy of the DETO2X-AMI (An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction) trial, the authors aimed to assess the analgesic effect of moderate-flow oxygen supplementation in patients with suspected acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) and to study the effect of oxygen supplementation on the use of opiates and sedatives during PCI. Background: Routine oxygen in normoxemic patients with AMI does not provide clinical benefit. However, oxygen may relieve ischemic pain. Methods: Patients were randomly allocated to oxygen or ambient air according to the main study protocol. After PCI, peak level of pain during PCI was measured by the Visual Analogue Scale. The total amount of opiates and sedatives was reported. Results: A total of 622 patients were enrolled: 330 in the oxygen group and 292 in the ambient air group. There was no significant difference in peak level of pain (oxygen 4.0 [1.0 to 6.0] vs. air 3.0 [0.6 to 6.0]; p = 0.37), use of opiates (mg) (oxygen 0.0 [0.0 to 3.0] vs. air 0.0 [0.0 to 3.0]; p = 0.31), or use of sedatives between the groups (median [interquartile range]) (oxygen 2.5 [0.0 to 2.5] vs. air 2.5 [0.0 to 2.5]; p = 0.74). Conclusions: In the present study, the authors did not find any analgesic effect of routine oxygen as compared with ambient air, and no differences in the use of sedatives and opiates during PCI. Our results indicate that moderate-flow oxygen supplementation does not relieve pain in normoxemic patients with suspected AMI undergoing treatment with PCI and should thus not be used for this purpose.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- analgesic effect
- oxygen
- ST-segment elevation myocardial infarction
- analgesic effect
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Sparv, David
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Hofmann, Robin
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Gunnarsson, Anni ...
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James, Stefan K, ...
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Hedberg, Camilla
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Lauermann, Jörg
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visa fler...
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Torild, Petronel ...
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Omerovic, Elmir
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Bergström, Krist ...
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Haugen, Espen
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Bergström, Camil ...
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Linder, Rikard
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Borg, Pia
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Haaga, Urban
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Olsson, Anneli
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Böving, Elin
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Östlund, Ollie
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Rylance, Rebecca
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Witt, Nils
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Erlinge, David
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James, SJ
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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JACC: Cardiovasc ...
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EUROPEAN HEART J ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet