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1.
  • Andrijevic, Goran, et al. (författare)
  • A fully integrated low-IF DVB-T receiver architecture
  • 2004
  • Ingår i: 2004 INTERNATIONAL SYMPOSIUM ON SYSTEM-ON-CHIP, PROCEEDINGS. - 0780385586 ; , s. 189-192
  • Konferensbidrag (refereegranskat)abstract
    • We propose a fully integrated DVB-T receiver architecture for low cost CMOS implementation. The receiver uses a dual-IF architecture to cover the receive bands from 170 MHz to 862 MHz and a Low-IF of 4.57 MHz. Key performance values meet the DVB-T requirements with competitive performance (Sensitivity 72.5 dBm, Noise Figure 66 dB, Adjacent Channel Protection Ratio-ACPR=43dB, available SNR=28 dB) and suggest that low cost receivers are realistic in volume for the coming digital broadcasting systems.
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2.
  • Andrijevic, Goran, et al. (författare)
  • Multistandard receiver for home networking and digital media
  • 2004
  • Ingår i: 22ND NORCHIP CONFERENCE, PROCEEDINGS. - NEW YORK : IEEE. - 0780385101 ; , s. 131-134
  • Konferensbidrag (refereegranskat)abstract
    • We propose a fully integrated multistandard receiver architecture that fulfills coming media and networking needs of homes. The receiver uses a dual-IF architecture to cover receive bands from 170 MHz to 920 MHz and the Industrial, Scientific and Medical (ISM) band at 2.4GHz. Key performance values meet the DVB-T, Zigbee, Bluetooth and 802.11b requirements (Sensitivity -72.5dBm. available SNR=28dB. Noise Figure 6.7dB. Adjacent Channel Protection Ratio-ACPR=-44dB, IIP3 = -11 dBm).
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3.
  • Attner, Bo, et al. (författare)
  • Cancer among patients with diabetes, obesity and abnormal blood lipids: a population-based register study in Sweden.
  • 2012
  • Ingår i: Cancer Causes and Control. - : Springer. - 1573-7225. ; 23:5, s. 769-777
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids. METHODS: Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile. RESULTS: Diabetes was significantly more common prior to diagnosis in patients with liver, pancreatic, colon and urinary tract/bladder cancer and in patients with breast cancer diagnosed with diabetes 0-4 years prior to the cancer diagnosis. A lower risk of diabetes was seen in patients with prostate carcinoma among individuals with diabetes diagnosed 5-10 years prior to the cancer diagnosis. The findings remained after adjusting for obesity and high blood lipids. Obesity was significantly more common in patients with endometrial, colon and kidney cancer and with breast cancer above the age of 60 years in those where obesity was diagnosed close to the diagnosis of cancer. High blood lipids were significantly more common in patients with ovarian cancer and less common in patients with breast cancer. CONCLUSIONS: The study confirms some previous findings concerning comorbidity and cancer and highlights some new ones.
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4.
  • Bryhn, Andreas, et al. (författare)
  • Fisk-och skaldjursbestånd i hav och sötvatten 2019 : resursöversikt
  • 2020
  • Rapport (övrigt vetenskapligt)abstract
    • Den femtonde upplagan av "Fisk- och skaldjursbestånd i hav och sötvatten – Resursöversikt" ger en samlad bild av fisk- och skaldjursbeståndens status i våra vatten. Årets resursöversikt visar de uppdaterade trenderna över de kommersiellt mest intressanta bestånden. Totalt redovisas underlag och råd för 50 fisk- och skaldjursarter.Beståndens trender respektive skattade storlek är en viktig kunskapsgrund för förvaltningen av arterna. Övervakningen av beståndens utveckling är även nödvändig för att följa upp effekterna av förvaltningsåtgärder.Arterna som presenteras i resursöversikten är också en del av de akvatiska miljöer som de lever i och de är därmed indikatorer på miljöns kvalitet. Vi ser att exempelvis torskbestånden i Östersjön har det svårt och vi vet att det är kopplat till ett minskat födointag och en utbredd syrebrist både i sediment och i vattenvolymer. Det är därför viktigt att man ser till hela ekosystemet. En del av rapporten beskriver den ekosystembaserade fiskeriförvaltningen och de ekosystemtjänster som våra hav, sjöar och vattendrag levererar.Rapporten riktar sig i första hand till tjänstemän på Havs- och vattenmyndigheten, länsstyrelser och andra som fattar beslut om fiskets förvaltning, men vi hoppas att många fler ska läsa den med intresse.
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5.
  • Harbst, Katja, et al. (författare)
  • Molecular and genetic diversity in the metastatic process of melanoma.
  • 2014
  • Ingår i: Journal of Pathology. - : John Wiley & Sons Inc.. - 0022-3417. ; 233:1, s. 39-50
  • Tidskriftsartikel (refereegranskat)abstract
    • Diversity between metastatic melanoma tumours in individual patients is known; however, the molecular and genetic differences remain unclear. To examine the molecular and genetic differences between metastatic tumours, we performed gene-expression profiling of 63 melanoma tumours obtained from 28 patients (two or three tumours/patient), followed by analysis of their mutational landscape, using targeted deep sequencing of 1697 cancer genes and DNA copy number analysis. Gene-expression signatures revealed discordant phenotypes between tumour lesions within a patient in 50% of the cases. In 18 of 22 patients (where matched normal tissue was available), we found that the multiple lesions within a patient were genetically divergent, with one or more melanoma tumours harbouring 'private' somatic mutations. In one case, the distant subcutaneous metastasis of one patient occurring 3 months after an earlier regional lymph node metastasis had acquired 37 new coding sequence mutations, including mutations in PTEN and CDH1. However, BRAF and NRAS mutations, when present in the first metastasis, were always preserved in subsequent metastases. The patterns of nucleotide substitutions found in this study indicate an influence of UV radiation but possibly also DNA alkylating agents. Our results clearly demonstrate that metastatic melanoma is a molecularly highly heterogeneous disease that continues to progress throughout its clinical course. The private aberrations observed on a background of shared aberrations within a patient provide evidence of continued evolution of individual tumours following divergence from a common parental clone, and might have implications for personalized medicine strategies in melanoma treatment. Published by John Wiley & Sons, Ltd. www.pathsoc.org.uk.
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6.
  • Jönsson, Göran B, et al. (författare)
  • The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer.
  • 2012
  • Ingår i: Cancer Research. - : American Association for Cancer Research Inc.. - 1538-7445. ; 72:16, s. 4028-4036
  • Tidskriftsartikel (refereegranskat)abstract
    • Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecularly subtype 577 breast tumors, including 72 breast tumors from BRCA1/2 mutation carriers. Focusing on the RB1 locus, we analyzed 33 BRCA1-mutated, 36 BRCA2-mutated and 48 non-BRCA1/2-mutated breast tumors using a custom-designed high-density oligomicroarray covering the RB1 gene. We found a strong association between the basal-like subtype and BRCA1-mutated breast tumors and the luminal B subtype and BRCA2-mutated breast tumors. RB1 was identified as a major target for genomic disruption in tumors arising in BRCA1 mutation carriers and in sporadic tumors with BRCA1 promoter-methylation, but rarely in other breast cancers. Homozygous deletions, intragenic breaks, or microdeletions were found in 33% of BRCA1-mutant tumors, 36% of BRCA1 promoter-methylated basal-like tumors, 13% of non-BRCA1 deficient basal-like tumors, and 3% of BRCA2-mutated tumors. In conclusion, RB1 was frequently inactivated by gross gene disruption in BRCA1-related hereditary breast cancer and BRCA1-methylated sporadic basal-like breast cancer, but rarely in BRCA2-hereditary breast cancer and non-BRCA1-deficient sporadic breast cancers. Together, our findings demonstrate the existence of genetic heterogeneity within the basal-like breast cancer subtype that is based upon BRCA1-status.
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7.
  • Lindqvist, Pelle G., et al. (författare)
  • Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study?
  • 2010
  • Ingår i: Diabetes Research and Clinical Practice. - : Elsevier. - 1872-8227. ; 90:1, s. 109-114
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim An inverse relationship exists between vitamin D levels and diabetes mellitus However, little is known about the correlation of sun exposure habits and type 2 diabetes mellitus (DM) Methods A South Swedish cohort study comprising 1000 women from each age group between 25 and 64 (n = 40,000) drawn from the Southern Swedish population registry 1990-1992 At the inception of the study 74% answered the inquiry (n = 29,518) and provided detailed information on their sun exposure habits and other variables A follow-up inquiry was sent 2000-2002 which 24,098 women answered The mean follow-up time was 11 years Logistic regression analysis was used and the main outcome was the relationship between type 2 DM and sun exposure habits. Results Our findings indicated that women with active sun exposure habits were at a 30% lower risk of having DM, as compared to those with non-active habits. There was an inverse relation between this risk reduction and BMI Conclusion Our investigation gives possible epidemiological explanation to ethnic and seasonal differences in type 2 DM and metabolic control The study supports that sunlight is involved in the glucose metabolism (C) 2010 Elsevier Ireland Ltd All rights reserved.
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8.
  • Lindqvist, P. G., et al. (författare)
  • Avoidance of sun exposure as a risk factor for major causes of death : A competing risk analysis of the Melanoma in Southern Sweden cohort
  • 2016
  • Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 0954-6820. ; 280:4, s. 375-387
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Women with active sunlight exposure habits experience a lower mortality rate than women who avoid sun exposure; however, they are at an increased risk of skin cancer. We aimed to explore the differences in main causes of death according to sun exposure. Methods: We assessed the differences in sun exposure as a risk factor for all-cause mortality in a competing risk scenario for 29 518 Swedish women in a prospective 20-year follow-up of the Melanoma in Southern Sweden (MISS) cohort. Women were recruited from 1990 to 1992 (aged 25-64 years at the start of the study). We obtained detailed information at baseline on sun exposure habits and potential confounders. The data were analysed using modern survival statistics. Results: Women with active sun exposure habits were mainly at a lower risk of cardiovascular disease (CVD) and noncancer/non-CVD death as compared to those who avoided sun exposure. As a result of their increased survival, the relative contribution of cancer death increased in these women. Nonsmokers who avoided sun exposure had a life expectancy similar to smokers in the highest sun exposure group, indicating that avoidance of sun exposure is a risk factor for death of a similar magnitude as smoking. Compared to the highest sun exposure group, life expectancy of avoiders of sun exposure was reduced by 0.6-2.1 years. Conclusion: The longer life expectancy amongst women with active sun exposure habits was related to a decrease in CVD and noncancer/non-CVD mortality, causing the relative contribution of death due to cancer to increase.
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9.
  • Lindqvist, P. G., et al. (författare)
  • Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort
  • 2014
  • Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 1365-2796. ; 276:1, s. 77-86
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to low vitamin D levels. Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-year follow-up of the Melanoma in Southern Sweden (MISS) cohort. Women were recruited from 1990 to 1992 and were aged 25 to 64 years at the start of the study. We obtained detailed information at baseline on their sun exposure habits and potential confounders. Multivariable flexible parametric survival analysis was applied to the data. Results. There were 2545 deaths amongst the 29 518 women who responded to the initial questionnaire. We found that all-cause mortality was inversely related to sun exposure habits. The mortality rate amongst avoiders of sun exposure was approximately twofold higher compared with the highest sun exposure group, resulting in excess mortality with a population attributable risk of 3%. Conclusion. The results of this study provide observational evidence that avoiding sun exposure is a risk factor for all-cause mortality. Following sun exposure advice that is very restrictive in countries with low solar intensity might in fact be harmful to women's health.
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10.
  • Lindqvist, Pelle G., et al. (författare)
  • Women with fair phenotypes seem to confer a survival advantage in a low UV milieu. A nested matched case control study
  • 2020
  • Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Sun exposure in combination with skin pigmentation is the main determinant for vitamin D status. Human skin color seems to be adapted and optimized for regional sun ultraviolet (UV) intensity. However, we do not know if fair, UV-sensitive skin is a survival advantage in regions with low UV radiation. Methods A population-based nested case-control study of 29,518 Caucasian women, ages 25 to 64 years from Southern Sweden who responded to a questionnaire regarding risk-factors for malignant melanoma in 1990 and followed for 25 years. For each fair woman, defined as having red hair or freckles (n = 11,993), a control was randomly selected from all non-fair women from within the cohort of similar age, smoking habits, education, marital status, income, and comorbidity, i.e., 11,993 pairs. The main outcome was the difference in allcause mortality between fair and non-fair women in a low UV milieu, defined as living in Sweden and having low-to-moderate sun exposure habits. Secondary outcomes were mortality by sun exposure, and among those non-overweight. Results In a low UV milieu, fair women were at a significantly lower all-cause mortality risk as compared to non-fair women (log rank test p = 0.04) with an 8% lower all-cause mortality rate (hazard ratio [HR] = 0.92, 95% CI 0.84-1.0), including a 59% greater risk of dying from skin cancer among fair women (HR 1.59, 95% CI 1.26-2.0). Thus, it seem that the beneficial health effect from low skin coloration outweigh the risk of skin cancer at high latitudes. Conclusion In a region with low UV milieu, evolution seems to improve all-cause survival by selecting a fair skin phenotype, i.e., comprising fair women with a survival advantage.
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