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Sökning: WFRF:(Orellana Muñoz S)

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  • de Rojas, I., et al. (författare)
  • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
  • 2021
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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  • Guerrero, Andrea, et al. (författare)
  • ALMA Lensing Cluster Survey: Average dust, gas, and star-formation properties of cluster and field galaxies from stacking analysis
  • 2023
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 526:2, s. 2423-2439
  • Tidskriftsartikel (refereegranskat)abstract
    • We develop new tools for continuum and spectral stacking of Atacama Large Millimeter/submillimeter Array (ALMA) data, and apply these to the ALMA Lensing Cluster Survey. We derive average dust masses, gas masses, and star-formation rates (SFRs) from the stacked observed 260-GHz continuum of 3402 individually undetected star-forming galaxies, of which 1450 are cluster galaxies and 1952 field galaxies, over three redshift and stellar mass bins (over z = 0-1.6 and log-11.7), and derive the average molecular gas content by stacking the emission line spectra in a SFR-selected subsample. The average SFRs and specific SFRs of both cluster and field galaxies are lower than those expected for main-sequence (MS) star-forming galaxies, and only galaxies with stellar mass of log-10.6 show dust and gas fractions comparable with those in the MS. The ALMA-Traced average 'highly obscured' SFRs are typically lower than the SFRs observed from optical to near-infrared spectral analysis. Cluster and field galaxies show similar trends in their contents of dust and gas, even when field galaxies were brighter in the stacked maps. From spectral stacking we find a potential CO (J = 4 → 3) line emission (signal-To-noise ratio being ∼4) when stacking cluster and field galaxies with the highest SFRs.
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  • Resultat 1-7 av 7

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