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Search: WFRF:(Page Paul) > (2020) > Uppsala University

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  • Fazey, Ioan, et al. (author)
  • Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
  • 2020
  • In: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
  • Journal article (peer-reviewed)abstract
    • Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
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2.
  • Folkersen, Lasse, et al. (author)
  • Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
  • 2020
  • In: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 2:10, s. 1135-1148
  • Journal article (peer-reviewed)abstract
    • Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
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Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Engström, Gunnar (1)
Landén, Mikael, 1966 (1)
Bergen, Sarah E (1)
Olsson, Per (1)
Lind, Lars (1)
Wang, Qin (1)
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Melander, Olle (1)
Nilsson, Peter M (1)
Smith, Gustav (1)
Elmståhl, Sölve (1)
Davey Smith, George (1)
Adams, David (1)
Sjögren, Marketa (1)
Zhang, Weidong (1)
O'Brien, Karen (1)
Aldunce, Paulina (1)
Nilsson, Jan (1)
Sundström, Johan, Pr ... (1)
Chen, Yan (1)
Franks, Paul W. (1)
Pereira, Laura (1)
Galafassi, Diego (1)
Johansson, Åsa (1)
Moore, Michele-Lee (1)
Orho-Melander, Marju (1)
Hamsten, Anders (1)
Ingelsson, Erik (1)
Luederitz, Christoph ... (1)
Ala-Korpela, Mika (1)
Enroth, Stefan, 1976 ... (1)
Light, Ann (1)
Wallentin, Lars, 194 ... (1)
Folkersen, Lasse (1)
Wu, Yang (1)
Andersson, Lotta (1)
Gyllensten, Ulf (1)
Ingason, Andrés (1)
Werge, Thomas (1)
De Masi, Federico (1)
Hedman, Åsa K (1)
Hesselgren, Mia, 196 ... (1)
Michaëlsson, Karl, 1 ... (1)
Gustafsson, Stefan (1)
Siegbahn, Agneta, 19 ... (1)
Wilson, James F. (1)
Ärnlöv, Johan (1)
Anderson, Lakin (1)
Ryan, Paul (1)
Peukert, Daniela (1)
Washbourne, Carla-Le ... (1)
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University
Uppsala University  (2)Undo refine
Lund University (2)
University of Gothenburg (1)
Royal Institute of Technology (1)
Stockholm University (1)
Chalmers University of Technology (1)
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Karlstad University (1)
Karolinska Institutet (1)
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Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Social Sciences (1)
Year
2020 (2)Undo refine

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