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Sökning: WFRF:(Palli Domenico) > Örebro universitet > Lifestyle factors f...

Lifestyle factors for the prevention of inflammatory bowel disease

Lopes, Emily W. (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
Chan, Simon S. M. (författare)
Department of Gastroenterology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK; Norwich Medical School, University of East Anglia, Norwich, UK,Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Gastroenterol, Norwich, Norfolk, England.;Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Harvard Univ TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
Song, Mingyang (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA
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Ludvigsson, Jonas F., 1969- (författare)
Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Pediatrics, Örebro universitet, Örebro, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Örebro Univ, Dept Pediat, Örebro, Sweden.
Håkansson, Niclas (författare)
Karolinska Institutet
Lochhead, Paul (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
Clark, Allan (författare)
Norwich Medical School, University of East Anglia, Norwich, UK,Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
Burke, Kristin E. (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
Ananthakrishnan, Ashwin N. (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
Cross, Amanda J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Cancer Screening & Prevention Research Group, Department of Surgery & Cancer, Imperial College London, London, UK,Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Imperial Coll London, Dept Surg & Canc, Canc Screening & Prevent Res Grp, London, England.
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy,Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy.
Bergmann, Manuela M. (författare)
Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany,German Inst Human Nutr Potsdam Rehbrucke, Epidemiol, Nuthetal, Germany.
Richter, James M. (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Brigham & Womens Hosp, Charming Div Network Med, Boston, MA 02115 USA.
Olén, Ola (författare)
Karolinska Institutet
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
Khalili, Hamed (författare)
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USAg; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA; Broad Institute, of MIT and Harvard, Cambridge, MA, USA,Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
EPIC-IBD investigators, - (bidragsgivare)
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Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA. (creator_code:org_t)
2022
2022
Engelska.
Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288.
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: To estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.DESIGN: In a prospective cohort study of US adults from the Nurses' Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0-6) for CD and UC based on established lifestyle risk factors, and healthy lifestyle scores (HLS; 0-9) derived from American healthy lifestyle recommendations. We calculated the population attributable risk by comparing the incidence of CD and UC between low-risk (CD-MRS≤1, UC-MRS≤2, HLS≥7) and high-risk groups. We externally validated our findings in three European cohorts: the Swedish Mammography Cohort (n=37 275), Cohort of Swedish Men (n=40 810) and European Prospective Investigation into Cancer and Nutrition (n=404 144).RESULTS: Over 5 117 021 person-years of follow-up (NHS, HPFS: 1986-2016; NHSII: 1991-2017), we documented 346 CD and 456 UC cases. Adherence to a low MRS could have prevented 42.9% (95% CI 12.2% to 66.1%) of CD and 44.4% (95% CI 9.0% to 69.8%) of UC cases. Similarly, adherence to a healthy lifestyle could have prevented 61.1% (95% CI 16.8% to 84.9%) of CD and 42.2% (95% CI 1.7% to 70.9%) of UC cases. In our validation cohorts, adherence to a low MRS and healthy lifestyle could have, respectively, prevented 43.9%-51.2% and 48.8%-60.4% of CD cases and 20.6%-27.8% and 46.8%-56.3% of UC cases.CONCLUSIONS: Across six US and European cohorts, a substantial burden of inflammatory bowel diseases risk may be preventable through lifestyle modification.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

Crohn's disease
diet
epidemiology
ulcerative colitis

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