Tyck till om SwePub Sök
här!
Search: WFRF:(Palmer J)
> (1991-1994)
> Lernmark Å >
Relating homology b...
Relating homology between the Epstein-Barr virus BOLF1 molecule and HLA-DQw8 β chain to recent onset Type 1 (insulin-dependent) diabetes mellitus
-
- Sairenji, T. (author)
- University of Massachusetts Medical School
-
- Daibata, M. (author)
- University of Massachusetts Medical School
-
- Sorli, C. H. (author)
- University of Massachusetts Medical School
-
show more...
-
Qvistbäck, H. (author)
-
- Humphreys, R. E. (author)
- University of Massachusetts Medical School
-
- Ludvigsson, J. (author)
- Linköping University
-
- Palmer, J. (author)
- Washington University School of Medicine
-
- Landin-Olsson, M. (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
-
- Sundkvist, G. (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
-
- Michelsen, B. (author)
- Hagedorn Research Institute
-
- Lernmark, Å (author)
- Washington University School of Medicine
-
- Dyrberg, T. (author)
- Hagedorn Research Institute
-
show less...
-
(creator_code:org_t)
- 1991
- 1991
- English.
-
In: Diabetologia. - 0012-186X. ; 34:1, s. 33-39
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- A role for the Epstein-Barr virus in initiating Type 1 (insulin-dependent) diabetes mellitus has been proposed since Epstein-Barr virus BOLF1(497-513) AVTPL RIFIVP PAAEY has an 11 amino acid identity with HLA-DQw8 β (49-60) AVTPL GPPAAEY. Rabbit antisera to the BOLF1 (496-515) peptide crossreacted with the homologous DQw8 β (44-63) peptide but not with the related DQw7 β(44-63) peptide, which differed from the DQw8 peptide only in an ALA to ASP substitution in position 57. Antisera to DQw8 β(49-60) reacted with the DQw8 β(44-63) peptide and BOLF1 (496-515), but not with DQw7 β (44-63). The antiserum to the BOLF1 peptide bound to denatured class II major histocompatibility complex β chains from Epstein-Barr virus-transformed DQw8-positive lymphocytes in an immunoblotting analysis. Epstein-Barr virus antibodies were detected at equal frequencies and similar titres in sera of 30 patients with Type 1 diabetes (16 of 30;63%) and in sera of 20 non-diabetic control subjects (13 of 20;65%). Sera from diabetic patients did not bind to DQw8 β (44-63) or BOLF1(496-515) peptides. From these data we conclude that there is no simple relationship between serological evidence of Epstein-Barr virus infection and crossreactions between homologous Epstein-Barr virus and class II major histocompatibility complex peptides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- class II MHC molecules
- EBV BOLF1
- Epstein-Barr virus
- molecular mimicry
- Type 1 (insulin-dependent) diabetes mellitus
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sairenji, T.
-
Daibata, M.
-
Sorli, C. H.
-
Qvistbäck, H.
-
Humphreys, R. E.
-
Ludvigsson, J.
-
show more...
-
Palmer, J.
-
Landin-Olsson, M ...
-
Sundkvist, G.
-
Michelsen, B.
-
Lernmark, Å
-
Dyrberg, T.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetologia
- By the university
-
Lund University