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Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group.

Abé, Christoph (author)
Karolinska Institutet
Ching, Christopher R K (author)
Liberg, Benny (author)
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Lebedev, Alexander V (author)
Agartz, Ingrid (author)
Karolinska Institutet
Akudjedu, Theophilus N (author)
Alda, Martin (author)
Alnæs, Dag (author)
Alonso-Lana, Silvia (author)
Benedetti, Francesco (author)
Berk, Michael (author)
Bøen, Erlend (author)
Bonnin, Caterina Del Mar (author)
Breuer, Fabian (author)
Brosch, Katharina (author)
Brouwer, Rachel M (author)
Canales-Rodríguez, Erick J (author)
Cannon, Dara M (author)
Chye, Yann (author)
Dahl, Andreas (author)
Dandash, Orwa (author)
Dannlowski, Udo (author)
Dohm, Katharina (author)
Elvsåshagen, Torbjørn (author)
Fisch, Lukas (author)
Fullerton, Janice M (author)
Goikolea, Jose M (author)
Grotegerd, Dominik (author)
Haatveit, Beathe (author)
Hahn, Tim (author)
Hajek, Tomas (author)
Heindel, Walter (author)
Ingvar, Martin (author)
Karolinska Institutet
Sim, Kang (author)
Kircher, Tilo T J (author)
Lenroot, Rhoshel K (author)
Malt, Ulrik F (author)
McDonald, Colm (author)
McWhinney, Sean R (author)
Melle, Ingrid (author)
Meller, Tina (author)
Melloni, Elisa M T (author)
Mitchell, Philip B (author)
Nabulsi, Leila (author)
Nenadić, Igor (author)
Opel, Nils (author)
Overs, Bronwyn J (author)
Panicalli, Francesco (author)
Pfarr, Julia-Katharina (author)
Poletti, Sara (author)
Pomarol-Clotet, Edith (author)
Radua, Joaquim (author)
Karolinska Institutet
Repple, Jonathan (author)
Ringwald, Kai G (author)
Roberts, Gloria (author)
Rodriguez-Cano, Elena (author)
Salvador, Raymond (author)
Sarink, Kelvin (author)
Sarró, Salvador (author)
Schmitt, Simon (author)
Stein, Frederike (author)
Suo, Chao (author)
Thomopoulos, Sophia I (author)
Tronchin, Giulia (author)
Vieta, Eduard (author)
Westlye, Lars T (author)
White, Adam G (author)
Yatham, Lakshmi N (author)
Zak, Nathalia (author)
Thompson, Paul M (author)
Andreassen, Ole A (author)
Landén, Mikael, 1966 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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 (creator_code:org_t)
Elsevier BV, 2022
2022
English.
In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 91:6, s. 582-592
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD.Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables.Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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By the author/editor
Abé, Christoph
Ching, Christoph ...
Liberg, Benny
Lebedev, Alexand ...
Agartz, Ingrid
Akudjedu, Theoph ...
show more...
Alda, Martin
Alnæs, Dag
Alonso-Lana, Sil ...
Benedetti, Franc ...
Berk, Michael
Bøen, Erlend
Bonnin, Caterina ...
Breuer, Fabian
Brosch, Katharin ...
Brouwer, Rachel ...
Canales-Rodrígue ...
Cannon, Dara M
Chye, Yann
Dahl, Andreas
Dandash, Orwa
Dannlowski, Udo
Dohm, Katharina
Elvsåshagen, Tor ...
Fisch, Lukas
Fullerton, Janic ...
Goikolea, Jose M
Grotegerd, Domin ...
Haatveit, Beathe
Hahn, Tim
Hajek, Tomas
Heindel, Walter
Ingvar, Martin
Sim, Kang
Kircher, Tilo T ...
Lenroot, Rhoshel ...
Malt, Ulrik F
McDonald, Colm
McWhinney, Sean ...
Melle, Ingrid
Meller, Tina
Melloni, Elisa M ...
Mitchell, Philip ...
Nabulsi, Leila
Nenadić, Igor
Opel, Nils
Overs, Bronwyn J
Panicalli, Franc ...
Pfarr, Julia-Kat ...
Poletti, Sara
Pomarol-Clotet, ...
Radua, Joaquim
Repple, Jonathan
Ringwald, Kai G
Roberts, Gloria
Rodriguez-Cano, ...
Salvador, Raymon ...
Sarink, Kelvin
Sarró, Salvador
Schmitt, Simon
Stein, Frederike
Suo, Chao
Thomopoulos, Sop ...
Tronchin, Giulia
Vieta, Eduard
Westlye, Lars T
White, Adam G
Yatham, Lakshmi ...
Zak, Nathalia
Thompson, Paul M
Andreassen, Ole ...
Landén, Mikael, ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Biological psych ...
By the university
University of Gothenburg
Karolinska Institutet

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