SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Pearson Richard D.)
 

Search: WFRF:(Pearson Richard D.) > (2010-2014) > (2010) > Singleton Andrew > Genetic variation i...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Saxena, Richa (author)
Hivert, Marie-France (author)
Langenberg, Claudia (author)
show more...
Tanaka, Toshiko (author)
Pankow, James S (author)
Vollenweider, Peter (author)
Lyssenko, Valeriya (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Bouatia-Naji, Nabila (author)
Dupuis, Josée (author)
Jackson, Anne U (author)
Kao, W H Linda (author)
Li, Man (author)
Glazer, Nicole L (author)
Manning, Alisa K (author)
Luan, Jian'an (author)
Stringham, Heather M (author)
Prokopenko, Inga (author)
Johnson, Toby (author)
Grarup, Niels (author)
Boesgaard, Trine W (author)
Lecoeur, Cécile (author)
Shrader, Peter (author)
O'Connell, Jeffrey (author)
Ingelsson, Erik (author)
Karolinska Institutet,Uppsala universitet,Geriatrik
Couper, David J (author)
Rice, Kenneth (author)
Song, Kijoung (author)
Andreasen, Camilla H (author)
Dina, Christian (author)
Köttgen, Anna (author)
Le Bacquer, Olivier (author)
Pattou, François (author)
Taneera, Jalal (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Steinthorsdottir, Valgerdur (author)
Rybin, Denis (author)
Ardlie, Kristin (author)
Sampson, Michael (author)
Qi, Lu (author)
van Hoek, Mandy (author)
Weedon, Michael N (author)
Aulchenko, Yurii S (author)
Voight, Benjamin F (author)
Grallert, Harald (author)
Balkau, Beverley (author)
Bergman, Richard N (author)
Bielinski, Suzette J (author)
Bonnefond, Amelie (author)
Bonnycastle, Lori L (author)
Borch-Johnsen, Knut (author)
Böttcher, Yvonne (author)
Brunner, Eric (author)
Buchanan, Thomas A (author)
Bumpstead, Suzannah J (author)
Cavalcanti-Proença, Christine (author)
Charpentier, Guillaume (author)
Chen, Yii-Der Ida (author)
Chines, Peter S (author)
Collins, Francis S (author)
Cornelis, Marilyn (author)
J Crawford, Gabriel (author)
Delplanque, Jerome (author)
Doney, Alex (author)
Egan, Josephine M (author)
Erdos, Michael R (author)
Firmann, Mathieu (author)
Forouhi, Nita G (author)
Fox, Caroline S (author)
Goodarzi, Mark O (author)
Graessler, Jürgen (author)
Hingorani, Aroon (author)
Isomaa, Bo (author)
Jørgensen, Torben (author)
Kivimaki, Mika (author)
Kovacs, Peter (author)
Krohn, Knut (author)
Kumari, Meena (author)
Lauritzen, Torsten (author)
Lévy-Marchal, Claire (author)
Mayor, Vladimir (author)
McAteer, Jarred B (author)
Meyre, David (author)
Mitchell, Braxton D (author)
Mohlke, Karen L (author)
Morken, Mario A (author)
Narisu, Narisu (author)
Palmer, Colin N A (author)
Pakyz, Ruth (author)
Pascoe, Laura (author)
Payne, Felicity (author)
Pearson, Daniel (author)
Rathmann, Wolfgang (author)
Sandbaek, Annelli (author)
Sayer, Avan Aihie (author)
Scott, Laura J (author)
Sharp, Stephen J (author)
Sijbrands, Eric (author)
Singleton, Andrew (author)
Siscovick, David S (author)
Smith, Nicholas L (author)
Sparsø, Thomas (author)
Swift, Amy J (author)
Syddall, Holly (author)
Thorleifsson, Gudmar (author)
Tönjes, Anke (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Valle, Timo T (author)
Waeber, Gérard (author)
Walley, Andrew (author)
Waterworth, Dawn M (author)
Zeggini, Eleftheria (author)
Zhao, Jing Hua (author)
Illig, Thomas (author)
Wichmann, H Erich (author)
Wilson, James F (author)
van Duijn, Cornelia (author)
Hu, Frank B (author)
Morris, Andrew D (author)
Frayling, Timothy M (author)
Hattersley, Andrew T (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Nilsson, Peter (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Syvänen, Ann-Christine (author)
Uppsala universitet,Molekylär medicin
Shuldiner, Alan R (author)
Walker, Mark (author)
Bornstein, Stefan R (author)
Schwarz, Peter (author)
Williams, Gordon H (author)
Nathan, David M (author)
Kuusisto, Johanna (author)
Laakso, Markku (author)
Cooper, Cyrus (author)
Marmot, Michael (author)
Ferrucci, Luigi (author)
Mooser, Vincent (author)
Stumvoll, Michael (author)
Loos, Ruth J F (author)
Altshuler, David (author)
Psaty, Bruce M (author)
Rotter, Jerome I (author)
Boerwinkle, Eric (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Florez, Jose C (author)
McCarthy, Mark I (author)
Boehnke, Michael (author)
Barroso, Inês (author)
Sladek, Robert (author)
Froguel, Philippe (author)
Meigs, James B (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Wareham, Nicholas J (author)
Watanabe, Richard M (author)
show less...
 (creator_code:org_t)
2010-01-17
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:2, s. 142-148
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Saxena, Richa
Hivert, Marie-Fr ...
Langenberg, Clau ...
Tanaka, Toshiko
Pankow, James S
Vollenweider, Pe ...
show more...
Lyssenko, Valeri ...
Bouatia-Naji, Na ...
Dupuis, Josée
Jackson, Anne U
Kao, W H Linda
Li, Man
Glazer, Nicole L
Manning, Alisa K
Luan, Jian'an
Stringham, Heath ...
Prokopenko, Inga
Johnson, Toby
Grarup, Niels
Boesgaard, Trine ...
Lecoeur, Cécile
Shrader, Peter
O'Connell, Jeffr ...
Ingelsson, Erik
Couper, David J
Rice, Kenneth
Song, Kijoung
Andreasen, Camil ...
Dina, Christian
Köttgen, Anna
Le Bacquer, Oliv ...
Pattou, François
Taneera, Jalal
Steinthorsdottir ...
Rybin, Denis
Ardlie, Kristin
Sampson, Michael
Qi, Lu
van Hoek, Mandy
Weedon, Michael ...
Aulchenko, Yurii ...
Voight, Benjamin ...
Grallert, Harald
Balkau, Beverley
Bergman, Richard ...
Bielinski, Suzet ...
Bonnefond, Ameli ...
Bonnycastle, Lor ...
Borch-Johnsen, K ...
Böttcher, Yvonne
Brunner, Eric
Buchanan, Thomas ...
Bumpstead, Suzan ...
Cavalcanti-Proen ...
Charpentier, Gui ...
Chen, Yii-Der Id ...
Chines, Peter S
Collins, Francis ...
Cornelis, Marily ...
J Crawford, Gabr ...
Delplanque, Jero ...
Doney, Alex
Egan, Josephine ...
Erdos, Michael R
Firmann, Mathieu
Forouhi, Nita G
Fox, Caroline S
Goodarzi, Mark O
Graessler, Jürge ...
Hingorani, Aroon
Isomaa, Bo
Jørgensen, Torbe ...
Kivimaki, Mika
Kovacs, Peter
Krohn, Knut
Kumari, Meena
Lauritzen, Torst ...
Lévy-Marchal, Cl ...
Mayor, Vladimir
McAteer, Jarred ...
Meyre, David
Mitchell, Braxto ...
Mohlke, Karen L
Morken, Mario A
Narisu, Narisu
Palmer, Colin N ...
Pakyz, Ruth
Pascoe, Laura
Payne, Felicity
Pearson, Daniel
Rathmann, Wolfga ...
Sandbaek, Annell ...
Sayer, Avan Aihi ...
Scott, Laura J
Sharp, Stephen J
Sijbrands, Eric
Singleton, Andre ...
Siscovick, David ...
Smith, Nicholas ...
Sparsø, Thomas
Swift, Amy J
Syddall, Holly
Thorleifsson, Gu ...
Tönjes, Anke
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Valle, Timo T
Waeber, Gérard
Walley, Andrew
Waterworth, Dawn ...
Zeggini, Elefthe ...
Zhao, Jing Hua
Illig, Thomas
Wichmann, H Eric ...
Wilson, James F
van Duijn, Corne ...
Hu, Frank B
Morris, Andrew D
Frayling, Timoth ...
Hattersley, Andr ...
Thorsteinsdottir ...
Stefansson, Kari
Nilsson, Peter
Syvänen, Ann-Chr ...
Shuldiner, Alan ...
Walker, Mark
Bornstein, Stefa ...
Schwarz, Peter
Williams, Gordon ...
Nathan, David M
Kuusisto, Johann ...
Laakso, Markku
Cooper, Cyrus
Marmot, Michael
Ferrucci, Luigi
Mooser, Vincent
Stumvoll, Michae ...
Loos, Ruth J F
Altshuler, David
Psaty, Bruce M
Rotter, Jerome I
Boerwinkle, Eric
Hansen, Torben
Pedersen, Oluf
Florez, Jose C
McCarthy, Mark I
Boehnke, Michael
Barroso, Inês
Sladek, Robert
Froguel, Philipp ...
Meigs, James B
Groop, Leif
Wareham, Nichola ...
Watanabe, Richar ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Other Clinical M ...
Articles in the publication
Nature Genetics
By the university
Uppsala University
Lund University
Karolinska Institutet

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view