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Associations betwee...
Associations between common genetic variants and income provide insights about the socioeconomic health gradient
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- Khalili, Bita (author)
- University of Lausanne
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- Lee, Yunsung (author)
- Norwegian Institute of Public Health
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- Li-Gao, Ruifang (author)
- Leiden University Medical Center
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- Masso, Jaan (author)
- University of Tartu
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- Myhre, Ronny (author)
- Norwegian Institute of Public Health
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- Palviainen, Teemu (author)
- University of Helsinki
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- Rietveld, Cornelius (author)
- Erasmus University Rotterdam
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- Koellinger, Philipp D. (author)
- Vrije Universiteit Amsterdam
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- Kweon, Hyeokmoon (author)
- Vrije Universiteit Amsterdam
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- Burik, Casper (author)
- Vrije Universiteit Amsterdam
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- Ning, Yuchen (author)
- Vrije Universiteit Amsterdam
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- Ahlskog, Rafael (author)
- Uppsala University
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- Xia, Charley (author)
- University of Edinburgh
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- Abner, Erik (author)
- University of Tartu
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- Bao, Yanchun (author)
- University of Essex
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- Bhatta, Laxmi (author)
- Norwegian University of Science and Technology
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- Faquih, Tariq (author)
- Brigham and Women's Hospital
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- de Feijter, Maud (author)
- Erasmus MC
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- Fisher, Paul (author)
- University of Essex
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- Gelemanović, Andrea (author)
- University of Split
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- Giannelis, Alexandros (author)
- University of Minnesota
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- Hottenga, Jouke-Jan (author)
- Vrije Universiteit Amsterdam
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- Teumer, Alexander (author)
- University of Greifswald
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- Verweij, Resnke (author)
- Erasmus University Rotterdam
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- Willoughby, Emily (author)
- University of Minnesota
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- Agerbo, Esben (author)
- Aarhus University
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- Bergmann, Sven (author)
- University of Lausanne
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- Boomsma, D (author)
- Vrije Universiteit Amsterdam
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- Borglum, Anders (author)
- Aarhus University
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- Brumpton, Ben (author)
- Norwegian University of Science and Technology
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- Davies, Neil (author)
- University of Bristol
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- Esko, Tonu (author)
- University of Tartu
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- Gordon, Scott D (author)
- QIMR Berghofer Medical Research Institute
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- Homuth, Georg (author)
- University of Greifswald
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- Ikram, M Arfan (author)
- Erasmus MC
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- Johannesson, Magnus (author)
- Stockholm School of Economics,Handelshögskolan i Stockholm
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- Kaprio, Jaakko (author)
- University of Helsinki
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- Kidd, Michael (author)
- RMIT University
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- Kutalik, Zoltán (author)
- University of Lausanne
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- Kwong, Alex (author)
- University of Bristol
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- Lee, James J. (author)
- University of Minnesota
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- Luik, Annemarie (author)
- Erasmus University Medical Center
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- Magnus, Per (author)
- Norwegian Institute of Public Health
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- Marques-Vidal, Pedro (author)
- University of Lausanne
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- Martin, Nicholas G (author)
- QIMR Berghofer Medical Research Institute
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- Mook-Kanamori, Dennis (author)
- Leiden University Medical Center
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- Mortensen, Preben (author)
- Aarhus University
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- Oskarsson, Sven (author)
- Uppsala University
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- Pedersen, Emil (author)
- Aarhus University
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- Polašek, Ozren (author)
- University of Split
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- Rosendaal, Frits (author)
- Leiden University Medical Center
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- Smart, Melissa C. (author)
- University of Essex
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- Snieder, Harold (author)
- University Medical Center Groningen
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- van der Most, Peter J (author)
- University Medical Center Groningen
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- Vollenweider, Peter (author)
- University Hospital of Lausanne
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- Völzke, Henry (author)
- Greifswald University Hospital
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- Willemsen, Gonneke (author)
- Vrije Universiteit Amsterdam
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- Beauchamp, Jonathan (author)
- George Mason University
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- DiPrete, Thomas (author)
- Columbia University
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- Karlsson Linnér, Richard (author)
- Leiden University
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- Lu, Qiongshi (author)
- University of Wisconsin–Madison
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- Morris, Tim (author)
- University of Bristol
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- Okbay, Aysu (author)
- Vrije Universiteit Amsterdam
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- Harden, K (author)
- The University of Texas at Austin
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- Abdellaoui, Abdel (author)
- Vrije Universiteit Amsterdam
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- Hill, William (author)
- University of Edinburgh
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- de Vlaming, Ronald (author)
- Vrije Universiteit Amsterdam
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- Benjamin, Daniel (author)
- University of California Los Angeles
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(creator_code:org_t)
- Research Square, 2024
- English.
- Related links:
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https://research.hhs... (primary) (Object in context)
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https://research.hhs...
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https://doi.org/10.2...
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Abstract
Subject headings
Close
- We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% of income variance, with only one-fourth attributed to direct genetic effects. A phenome-wide association study using this polygenic index showed reduced risks for a broad spectrum of diseases, including hypertension, obesity, type 2 diabetes, coronary atherosclerosis, depression, asthma, and back pain. The income factor showed a substantial genetic correlation (0.92, s.e. = .006) with educational attainment (EA). Accounting for EA's genetic overlap with income revealed that the remaining genetic signal for higher income related to better mental health but reduced physical health benefits and increased participation in risky behaviours such as drinking and smoking.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ovr (subject category)
- vet (subject category)
To the university's database
- By the author/editor
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Khalili, Bita
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Lee, Yunsung
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Li-Gao, Ruifang
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Masso, Jaan
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Myhre, Ronny
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Palviainen, Teem ...
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show more...
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Rietveld, Cornel ...
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Koellinger, Phil ...
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Kweon, Hyeokmoon
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Burik, Casper
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Ning, Yuchen
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Ahlskog, Rafael
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Xia, Charley
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Abner, Erik
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Bao, Yanchun
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Bhatta, Laxmi
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Faquih, Tariq
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de Feijter, Maud
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Fisher, Paul
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Gelemanović, And ...
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Giannelis, Alexa ...
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Hottenga, Jouke- ...
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Teumer, Alexande ...
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Verweij, Resnke
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Willoughby, Emil ...
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Agerbo, Esben
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Bergmann, Sven
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Boomsma, D
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Borglum, Anders
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Brumpton, Ben
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Davies, Neil
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Esko, Tonu
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Gordon, Scott D
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Homuth, Georg
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Ikram, M Arfan
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Johannesson, Mag ...
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Kaprio, Jaakko
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Kidd, Michael
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Kutalik, Zoltán
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Kwong, Alex
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Lee, James J.
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Luik, Annemarie
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Magnus, Per
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Marques-Vidal, P ...
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Martin, Nicholas ...
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Mook-Kanamori, D ...
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Mortensen, Prebe ...
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Oskarsson, Sven
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Pedersen, Emil
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Polašek, Ozren
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Rosendaal, Frits
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Smart, Melissa C ...
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Snieder, Harold
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van der Most, Pe ...
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Vollenweider, Pe ...
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Völzke, Henry
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Willemsen, Gonne ...
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Beauchamp, Jonat ...
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DiPrete, Thomas
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Karlsson Linnér, ...
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Lu, Qiongshi
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Morris, Tim
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Okbay, Aysu
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Harden, K
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Abdellaoui, Abde ...
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Hill, William
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de Vlaming, Rona ...
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Benjamin, Daniel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- By the university
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Stockholm School of Economics