SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Pereira Maria J)
 

Search: WFRF:(Pereira Maria J) > (2010-2014) > Fenyö Eva Maria > Enhanced CD4+cellul...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Enhanced CD4+cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection

Wade, Jessica (author)
Sterjovski, Jasminka (author)
Gray, Lachlan (author)
show more...
Roche, Ichael (author)
Chiavaroli, Lisa (author)
Ellett, Anne (author)
Jakobsen, Martin R. (author)
Cowley, Daniel (author)
Pereira, Candida da Fonseca (author)
Saksena, Nitin (author)
Wang, Bin (author)
Purcell, Damian F. J. (author)
Karlsson, Ingrid (author)
Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
Fenyö, Eva Maria (author)
Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
Churchill, Melissa (author)
Gorry, Paul R. (author)
show less...
 (creator_code:org_t)
Elsevier BV, 2010
2010
English.
In: Virology. - : Elsevier BV. - 1096-0341 .- 0042-6822. ; 396:2, s. 246-255
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) strains cause CD4+ T-cell loss in most infected individuals, but mechanisms underlying cytopathicity of R5 viruses are poorly understood. We investigated mechanisms contributing to R5 envelope glycoprotein (Env)-mediated cellular apoptosis by constructing a panel of retroviral vectors engineered to co-express GFP and R5 Envs derived from two HIV-1 infected subjects spanning asymptomatic (Early, E-R5 Envs) to late stages of infection (Late, L-R5 Envs). The L-R5 Envs induced significantly more cellular apoptosis than E-R5 Envs, but only in Env-expressing (GFP-positive) cells, and only in cells where CD4 and CCR5 levels were limiting. Studies with fusion-defective Env mutants showed induction of apoptosis required membrane-fusing events. Our results provide evidence for an intracellular mechanism of R5 Env-induced apoptosis of CD4+ cells that requires membrane fusion. Furthermore, they contribute to a better understanding of mechanisms involved in CD4+ T-cell loss in subjects experiencing progressive R5 HIV-1 infection. (C) 2009 Elsevier Inc. All rights reserved.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Active caspase-3
Apoptosis
CCR5
CD4
HIV-1
Env

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

  • Virology (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view