Search: WFRF:(Pereira Maria J)
> (2010-2014)
> Fenyö Eva Maria >
Enhanced CD4+cellul...
Enhanced CD4+cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection
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Wade, Jessica (author)
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Sterjovski, Jasminka (author)
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Gray, Lachlan (author)
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Roche, Ichael (author)
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Chiavaroli, Lisa (author)
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Ellett, Anne (author)
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Jakobsen, Martin R. (author)
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Cowley, Daniel (author)
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Pereira, Candida da Fonseca (author)
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Saksena, Nitin (author)
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Wang, Bin (author)
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Purcell, Damian F. J. (author)
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- Karlsson, Ingrid (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Fenyö, Eva Maria (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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Churchill, Melissa (author)
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Gorry, Paul R. (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Virology. - : Elsevier BV. - 1096-0341 .- 0042-6822. ; 396:2, s. 246-255
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) strains cause CD4+ T-cell loss in most infected individuals, but mechanisms underlying cytopathicity of R5 viruses are poorly understood. We investigated mechanisms contributing to R5 envelope glycoprotein (Env)-mediated cellular apoptosis by constructing a panel of retroviral vectors engineered to co-express GFP and R5 Envs derived from two HIV-1 infected subjects spanning asymptomatic (Early, E-R5 Envs) to late stages of infection (Late, L-R5 Envs). The L-R5 Envs induced significantly more cellular apoptosis than E-R5 Envs, but only in Env-expressing (GFP-positive) cells, and only in cells where CD4 and CCR5 levels were limiting. Studies with fusion-defective Env mutants showed induction of apoptosis required membrane-fusing events. Our results provide evidence for an intracellular mechanism of R5 Env-induced apoptosis of CD4+ cells that requires membrane fusion. Furthermore, they contribute to a better understanding of mechanisms involved in CD4+ T-cell loss in subjects experiencing progressive R5 HIV-1 infection. (C) 2009 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Active caspase-3
- Apoptosis
- CCR5
- CD4
- HIV-1
- Env
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wade, Jessica
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Sterjovski, Jasm ...
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Gray, Lachlan
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Roche, Ichael
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Chiavaroli, Lisa
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Ellett, Anne
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show more...
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Jakobsen, Martin ...
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Cowley, Daniel
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Pereira, Candida ...
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Saksena, Nitin
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Wang, Bin
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Purcell, Damian ...
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Karlsson, Ingrid
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Fenyö, Eva Maria
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Churchill, Melis ...
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Gorry, Paul R.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Virology
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Lund University