| 1. |
- Andersson, Daniel, et al.
(författare)
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Indigenous Religions
- 2024
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Ingår i: The Study of Religion in Sweden. - London : Bloomsbury Academic. - 9781350413283 - 9781350413290 ; , s. 55-67
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Bokkapitel (refereegranskat)
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| 2. |
- Brunkwall, Louise, et al.
(författare)
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The Malmö Offspring Study (MOS) : design, methods and first results.
- 2021
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Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 36, s. 103-116
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Tidskriftsartikel (refereegranskat)abstract
- As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better explain these associations. Shared lifestyle and social conditions in families, but also early life influences may be of importance. Gene-environmental interactions should be explored. In recent years interest has grown for the role of diet-microbiota associations, as microbiota patterns may be shared by family members. In the Malmö Offspring Study that started in 2013, we have so far been able to examine about 4700 subjects (18-71 years) representing children and grandchildren of index subjects from the first generation, examined in the Malmö Diet Cancer Study during 1991 to 1996. This will provide rich data and opportunities to analyse family traits of chronic disease across three generations. We will provide extensive genotyping and phenotyping including cardiovascular and respiratory function, as well as markers of glucose metabolism. In addition, also cognitive function will be assessed. A 4-day online dietary recall will be conducted and gut as well as oral microbiota analysed. The ambition is to provide one of the first large-scale European family studies with individual data across three generations, which could deepen our knowledge about the role of family traits for chronic disease and its underlying mechanisms.
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| 3. |
- Flodbring Larsson, Per, et al.
(författare)
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FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
- 2022
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Ingår i: Molecular Oncology. - : John Wiley & Sons. - 1574-7891 .- 1878-0261.
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Tidskriftsartikel (refereegranskat)abstract
- Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of FcγRIIIa in prostate cancer (PCa) progression remained unknown. In this study, we found that FcγRIIIa expression was present in PCa cells and its level was significantly higher in metastatic lesions than in primary tumors from the PCa cohort (P = 0.006). PCa patients with an elevated level of FcγRIIIa expression had poorer biochemical recurrence (BCR)-free survival compared with those with lower FcγRIIIa expression, suggesting that FcγRIIIa is of clinical importance in PCa. We demonstrated that overexpression of FcγRIIIa increased the proliferative ability of PCa cell line C4-2 cells, which was accompanied by the upregulation of androgen receptor (AR) and phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), which are the key players in controlling PCa progression. Conversely, targeted inhibition of FcγRIIIa via siRNA-mediated knockdown or using its inhibitory antibody suppressed growth of xenograft PC-3 and PC-3M prostate tumors and reduced distant metastasis in xenograft mouse models. We further showed that elevated expression of AR enhanced FcγRIIIa expression, whereas inhibition of AR activity using enzalutamide led to a significant downregulation of FcγRIIIa protein expression. Similarly, inhibition of PIP5K1α decreased FcγRIIIa expression in PCa cells. FcγRIIIa physically interacted with PIP5K1α and AR via formation of protein-protein complexes, suggesting that FcγRIIIa is functionally associated with AR and PIP5K1α in PCa cells. Our study identified FcγRIIIa as an important factor in promoting PCa growth and invasion. Further, the elevated activation of FcγRIII and AR and PIP5K1α pathways may cooperatively promote PCa growth and invasion. Thus, FcγRIIIa may serve as a potential new target for improved treatment of metastatic and castration-resistant PCa.
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| 4. |
- Kolbus, Daniel, et al.
(författare)
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CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe-/- mice.
- 2010
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Ingår i: BMC Immunology. - : Springer Science and Business Media LLC. - 1471-2172. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- It is well established that adaptive immune responses induced by hypercholesterolemia play an important role in the development of atherosclerosis, but the pathways involved remain to be fully characterized. In the present study we assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks.
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| 5. |
- Olofsson, Jonas, et al.
(författare)
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Sweden : the formative period for VET (1850-1945)
- 2018
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Ingår i: Vocational education in the Nordic countries. - Abingdon, Oxon ; New York, NY : Routledge is an imprint of the Taylor & Francis Group, an Informa Business, [2018] | Series: Routledge research in international and comparative education : Routledge. - 9781138220850 - 9781315411811 ; , s. 46-65
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Bokkapitel (refereegranskat)abstract
- This chapter examines the period for VET in Sweden that stretches from the dissolution of the guilds by the passing of the Free Trade Act in 1864 until 1945. The period is described as a movement from unregulated apprenticeship to state-regulated, school-based vocational education. The breakthrough of modern industry in Sweden led to a strong demand for a different and school-based vocational education. The trade union organisation and employer organisation gradually agreed that publicly organised VET should be strengthened and that apprenticeships should function as a complement, not as a main road for vocational learning.
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| 6. |
- Olofsson, Jonas, et al.
(författare)
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The modern evolution of VET in Sweden (1945-2015)
- 2018
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Ingår i: Vocational education in the Nordic countries. - Abingdon, Oxon ; New York, NY : Routledge is an imprint of the Taylor & Francis Group, an Informa Business, [2018] | Series: Routledge research in international and comparative education : Routledge. - 9781138220850 - 9781315411811 ; , s. 124-145
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Bokkapitel (refereegranskat)abstract
- This chapter illustrates how the Swedish VET trajectories (1945–2015) have been shaped by reforms and negotiations between the state and the labour market organisations. Three distinguished phases are traced. From the end of the 1940s, municipal vocational schools underwent a strong expansion. The second phase began with the establishment of coherent upper secondary schools through a reform in 1971. VET became a part of an integrated education system at upper secondary level. The third phase can be interpreted as a reorientation of the Swedish VET-system. The Swedish homogeneous VET-system tends to be more differentiated and controlled by the industries’ requirements.
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| 7. |
- Ottosson, Filip, et al.
(författare)
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The inverse association between a fish consumption biomarker with gingival inflammation and periodontitis : a population-based study
- 2022
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Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 49:4, s. 353-361
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The metabolite 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish-intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as extent and severity variables.METHODS: The Malmö Offspring Study (MOS) is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography-mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, BMI, fasting glucose and smoking.RESULTS: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (beta -2.12, p=0.002), and lower odds of severe periodontitis (OR 0.74, 95% CI=0.56-0.98). Higher CMPF levels were also associated with more teeth (beta 0.19, p=0.001), lower number of periodontal pockets (>4 mm) (beta -1.07, p=0.007) and lower odds of having two or more >6 mm periodontal pockets (OR 0.80, 95% CI=0.65-0.98) in fully adjusted models.CONCLUSION: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out and future studies are warranted. This article is protected by copyright. All rights reserved.
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| 8. |
- Spikol, Daniel
(creator_code:cre_t, creator_code:res_t)
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Forskarnas galleri #5 : People have the power: IOTAP on exhibit
- 2018
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Konstnärligt arbeteabstract
- Överallt samlar sensorer data som analyseras för att räkna ut hur man sparar energi, hur mycket insulin som ska injiceras, var den närmaste hyrbilen finns, hur många människor som fortfarande är kvar inne i en brinnande byggnad... Denna snabba spridning av teknik kallas för Sakernas Internet, eller IoT. Människor har makten, eller har vi verkligen det? Hur mycket värderar vi vår integritet? Vilka internetanslutna gadgets hjälper oss att leva ett hälsosamt och hållbart liv - och vilka prylar kommer bara att öka vår stressnivå? När blir användningen missbruk? Utställningen undersöker hur IoT påverkar människor, samhälle och industri. Forskningsprojekt i utställningen: Emergent Configuration for IoT Systems (ECOS+), Smart energy management and security (SEMS), Fair Data, Walk the ward, Dynamic Intelligent Sensor-Intensive Systems (DISS), PELARS-projektet och Busrunner presenteras i "IOTAP-labbet"
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| 9. |
- Spikol, Daniel, et al.
(författare)
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Kunskapsbaserad teknik för kompetensutveckling i byggsektorn : en forskningsrapport från Sveriges Byggindustrier
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med rapporten är att undersöka kunskapsförsörjningen inom byggsektorn på tre nivåer, gymnasium, yrkeshögskola och universitet/högskola samt en industriell partner. Projektet genomfördes med intervjuer, workshops och enkäter styrda av en grundlig litteraturstudie som tittat på aktuell forskning inom utbildning och pedagogik. Resultaten från projektet visar att lärare och elever/studenter har digitala kompetensen, men det finns utrymme för förbättringar av lärandematerial och processer. Dessutom visar resultaten från industrin ett starkt intresse för bättre utnyttja informationsteknik för kompetensutveckling. Betänkandet pekar på att det krävs fortsatt utveckling för en förbättra utbildning inom byggbranschen.
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| 10. |
- Sundström Sjödin, Elin, et al.
(författare)
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Läsning, ekologi och siffror : Sanningspraktiker hos en läsfrämjande aktör
- 2024
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Ingår i: Språk och litteratur - en omöjlig eller skön förening?. - Lund : Nationella nätverket för svenska med didaktisk inriktning. - 9789189874398 - 9789189874404 ; , s. 377-390
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- I denna artikel redogör vi för en mindre delstudie i det pågående, och av Vetenskapsrådet finansierade, projektet Från ord till siffror. Hur läsning blir ett samhälleligt och didaktiskt problem. Med hjälp av teoretiska och metodologiska perspektiv från Science- and Technology Studies (STS) undersöker vi i projektet hur forskning, läsfrämjande aktörer och skolans svenskundervisning deltar i och konstruerar diskurser om läsningens nödvändighet. I den delstudie som är aktuell här fokuserar vi på Sveriges Författarförbund (SFF) och deras lansering av ett litteraturpolitiskt program under våren 2022. Vi undersöker på vilka sätt SFF använder exempelvis metaforen om litteraturens ekosystem och siffror som sanningsskapande praktiker. Det empiriska materialet består av SFF:s tryckta litteraturpolitiska program från 2022, en intervju med förbundets vice ordförande, samt fältanteckningar från en heldagskonferens om litteraturpolitik arrangerad av SFF. Analysen visar att ekologi och siffror är kraftfulla tekniker som skapar en berättelse om läsningens nödvändighet och utsatthet, samtidigt som dessa sanningspraktiker också genererar motsägelser och motsättningar. Läsning etableras här såväl som oumbärligt för samhället och individen, och som under hot från en mängd aktörer och processer, däribland marknadifieringen och digitaliseringen.
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