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Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model

Zallar, L J (author)
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Tunstall, B J (author)
Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Richie, C T (author)
Genetic Engineering and Viral Vector Core, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
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Zhang, Y J (author)
Genetic Engineering and Viral Vector Core, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, Rockville, MD, USA
You, Z B (author)
Neuropsychopharmacology Section, Molecular Targets and Medications Discover Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Gardner, E L (author)
Neuropsychopharmacology Section, Molecular Targets and Medications Discover Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Heilig, Markus, 1959- (author)
Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken inkl beroendekliniken
Pickel, J (author)
Transgenic Core Facility, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Koob, G F (author)
Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Vendruscolo, L F (author)
Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Harvey, B K (author)
Molecular Mechanisms of Cellular Stress and Inflammation Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA
Leggio, L- (author)
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. lorenzo.leggio@nih.gov; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA
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 (creator_code:org_t)
2018-01-30
2019
English.
In: International Journal of Obesity. - : Nature Pub. Group. - 0307-0565 .- 1476-5497. ; 43:2, s. 344-354
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by binding to the growth hormone secretagogue receptor (GHSR). Here, we present the development, verification, and initial characterization of a novel GHSR knockout (KO) Wistar rat model created with CRISPR genome editing.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

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