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- Campanella, A., et al.
(författare)
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Additional booster doses in patients with chronic lymphocytic leukemia induce humoral and cellular immune responses to SARS-CoV-2 similar to natural infection regardless ongoing treatments : A study by ERIC, the European Research Initiative on CLL
- 2024
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Ingår i: American Journal of Hematology. - : John Wiley & Sons. - 0361-8609 .- 1096-8652. ; 99:4, s. 745-750
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Profound immune dysregulation and impaired response to the SARS-CoV-2 vaccine put patients with chronic lymphocytic leukemia (CLL) at risk of severe COVID-19. We compared humoral memory and T-cell responses after booster dose vaccination or breakthrough infection. (Green) Quantitative determination of anti-Spike specific antibodies. Booster doses increased seroconversion rate and antibody titers in all patient categories, ultimately generating humoral responses similar to those observed in the postinfection cohort. In detail, humoral response with overscale median antibody titers arose in >80% of patients in watch and wait, off-therapy in remission, or under treatment with venetoclax single-agent. Anti-CD20 antibodies and active treatment with BTK inhibitors (BTKi) represent limiting factors of humoral response, still memory mounted in ~40% of cases following booster doses or infection. (Blue) Evaluation of SARS-CoV-2-specific T-cell responses. Number of T-cell functional activation markers documented in each patient. The vast majority of patients, including those seronegative, developed T-cell responses, qualitatively similar between treatment groups or between vaccination alone and infection cases. These data highlight the efficacy of booster doses in eliciting T-cell immunity independently of treatment status and support the use of additional vaccination boosters to stimulate humoral immunity in patients on active CLL-directed treatments.
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- Bagriy, I.D., et al.
(författare)
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H2 - Ecological source of decarbonization - The path to energy independence of Ukraine
- 2023
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- The research studied the pressing problem of the fuel and energy strategy of the XXI century. For the first time, there was shown the diversity of the authors' approach to theoretical and applied problems of hydrogen energy. General issues of fundamental and applied aspects of hydrogen origin were covered. The study provides the results of scientific developments on hydrogen mapping performed within the framework of scientific and practical exploratory and geo-ecological research on more than 200 hydrocarbon objects both on land (including mining fields) and in marine water areas. Prognostic and search system criteria were substantiated, with hydrogen being used for the first time as a component of the complex of methodical solutions in the search practice. The research showed the importance of solving the problem of geo-ecological processes and accidents in mine workings and wells, connected to numerous disasters. According to numerous studies of mine massives, a set of preventive measures and criteria that prevent explosive processes was provided.The presence of a unique complex of natural components of hydrogen technology, solar and wind energy resources and fresh waters of the Danube lakes and the Danube was stated.The study emphasises the decisive role of Ukraine in the competition for primacy in scientific developments. For the first time in world practice, the implementation of global projects for the extraction and production of green and white hydrogen was substantiated.The technology was tested on numerous hydrocarbon deposits, water resources and mine workings and therefore has all the prospects for the effective application in the search and extraction of hydrogen. This monograph can be useful and informative for specialists in the fields of oil and gas geology, general and regional geology, hydrology, environmental protection, as well as for the students and postgraduate students of fuel and energy, oil and gas geological and hydrological areas, as well as for domestic and foreign investors.
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- Feldstein, Y. I., et al.
(författare)
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Auroral electrojets and 3D currents in the ionosphere-magnetosphere system
- 2006
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Ingår i: “Physics of Auroral Phenomena”, Proc. XXIX Annual Seminar, Apatity. - : Kola Science Centre, Russian Academy of Science. ; , s. 25-30
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- There are shortly described results of the analysis of variations in the location and intensity of the auroral electrojets during magnetic storms and substorms using a numerical method for estimating the equivalent ionospheric currents based on data from meridian chains of magnetic observatories. It is shown that the westward electrojet adjoins to the polar electrojet located at cusp latitudes in the dayside sector. The association of electrojets with the field-aligned currents (FACs), namely Region 1 FAC and Region 2 FAC is considered. During intense disturbances a Region 3 FAC (accompanied with diffuse electron precipitation from the plasma sheet boundary layer) with the downward current was identified. The analysis of observational data is summarized in terms of 2D time-latitude distribution of electrojets at ionospheric altitudes. The magnetic field sawtooth variations generated during the storm main and early recovery phases are also discussed. To follow 3D currents in the magnetosphereionosphere system a clarified view of interrelated 3D currents and magnetospheric plasma domains is presented.
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