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Träfflista för sökning "WFRF:(Qi Jun) ;pers:(Qi Jun)"

Sökning: WFRF:(Qi Jun) > Qi Jun

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  • Bandopadhayay, Pratiti, et al. (författare)
  • BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
  • 2014
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 20:4, s. 912-925
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose:MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. The compound JQ1 inhibits BET bromodomain-containing proteins, including BRD4. Here, we investigate BET bromodomain targeting for the treatment of MYC-amplified medulloblastoma.Experimental Design:We evaluated the effects of genetic and pharmacologic inhibition of BET bromodomains on proliferation, cell cycle, and apoptosis in established and newly generated patient- and genetically engineered mouse model (GEMM)-derived medulloblastoma cell lines and xenografts that harbored amplifications of MYC or MYCN. We also assessed the effect of JQ1 on MYC expression and global MYC-associated transcriptional activity. We assessed the in vivo efficacy of JQ1 in orthotopic xenografts established in immunocompromised mice.Results:Treatment of MYC-amplified medulloblastoma cells with JQ1 decreased cell viability associated with arrest at G1 and apoptosis. We observed downregulation of MYC expression and confirmed the inhibition of MYC-associated transcriptional targets. The exogenous expression of MYC from a retroviral promoter reduced the effect of JQ1 on cell viability, suggesting that attenuated levels of MYC contribute to the functional effects of JQ1. JQ1 significantly prolonged the survival of orthotopic xenograft models of MYC-amplified medulloblastoma (P < 0.001). Xenografts harvested from mice after five doses of JQ1 had reduced the expression of MYC mRNA and a reduced proliferative index.Conclusion:JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, resulting in an overall decrease in medulloblastoma cell viability. These preclinical findings highlight the promise of BET bromodomain inhibitors as novel agents for MYC-amplified medulloblastoma.
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  • Bolin, Sara, 1988-, et al. (författare)
  • Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
  • 2018
  • Ingår i: Oncogene. - : Nature Publishing Group. - 0950-9232 .- 1476-5594. ; 37:21, s. 2850-2862
  • Tidskriftsartikel (refereegranskat)abstract
    • Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs) are further known to support MYC stabilization in tumor cells. In this report, MB cells were suppressed by combined targeting of MYC expression and MYC stabilization using BET bromodomain inhibition and CDK2 inhibition, respectively. Such combination treatment worked synergistically and caused cell cycle arrest as well as massive apoptosis. Immediate transcriptional changes from this combined MYC blockade were found using RNA-Seq profiling and showed remarkable similarities to changes in MYC target gene expression when MYCN was turned off with doxycycline in our MYCN-inducible animal model for Group 3 MB. In addition, the combination treatment significantly prolonged survival as compared to single-agent therapy in orthotopically transplanted human Group 3 MB with MYC amplifications. Our data suggest that dual inhibition of CDK2 and BET bromodomains can be a novel treatment approach for suppressing MYC-driven cancer.
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  • Huang, Juan, et al. (författare)
  • Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry
  • 2022
  • Ingår i: BMC Biomedical chromotography. - : John Wiley & Sons. - 0269-3879 .- 1099-0801. ; 36:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Ginsenosides have poor oral bioavailability and undergo rapid biological transformation in the complex gastrointestinal environment. Most studies on the metabolism of ginsenosides have focused on gut bacteria, yet gastric juice remains a nonnegligible factor. Metabolic profiles of ginsenoside monomers formed in artificial gastric juice were separately investigated and qualitatively identified using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MSn). A common pattern of their metabolic pathways was established, showing that ginsenosides were transformed via deglycosylation, hydration, and dehydration pathways. Two major structure types, 20(S), 20(R)-protopanaxatriols and 20(S), 20(R)-protopanaxadiols, basically shared similar transformation pathways and yielded deglycosylated, hydrated, and dehydrated products. Fragmentation patterns of major ginsenosides were also discussed. Consequently, gastric juice, as the primary link in ginsenoside metabolism and as important as the intestinal flora, produces considerable amounts of degraded ginsenosides, providing a partial explanation for the low bioavailabilities of primary ginsenosides.
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  • Qi, Jun, et al. (författare)
  • IoTBDH-2023: The 5th International Workshop on Internet of Things of Big Data for Healthcare
  • 2023
  • Ingår i: CIKM 2023 - Proceedings of the 32nd ACM International Conference on Information and Knowledge Management. - : Association for Computing Machinery. ; , s. 5285-5288
  • Konferensbidrag (refereegranskat)abstract
    • Internet of Things (IoT) enabled technology has rapidly and efficiently facilitate healthcare diagnose and treatment with low-cost and lightweight devices. Big data generated from IoT offers valuable and crucial information to guide decision-making, improve patient outcomes, and decrease healthcare costs, etc. The workshop is aiming to provide an opportunity for researchers and practitioners from both academia and industry to present the state-of-the-art research and applications in utilizing IoT and big data technology for healthcare by presenting efficient scientific and engineering solutions, addressing the needs and challenges for integration with new technologies, and providing visions for future research and development.
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  • Shi, Lin, et al. (författare)
  • Context-based Ontology-driven Recommendation Strategies for Tourism in Ubiquitous Computing
  • 2014
  • Ingår i: Wireless personal communications. - : Springer Science and Business Media LLC. - 0929-6212 .- 1572-834X. ; 76:4, s. 731-745
  • Tidskriftsartikel (refereegranskat)abstract
    • Tourism is an information-intensive business. At present, there are a lot of information and tourism resources available on the internet that lead to low searching efficiency and effectiveness, the user may get too many seeking results but not related to his interest, or few results than his expected. The user can know clearly what he wants, but sometime the user doesn't know what kind information he needs. User's demand can be formulated as direct demand and potential preference. At the same time, the study shows that there is strong relationship between the traveler's potential preference and the characteristics of tourism resources. In order to solve the information overload challenge, recommendation services are increasingly emerging. Currently, recommendation methods focus on dealing with personalized matching based on the user preference. However, these methods skip the user's direct demand. In this paper, we propose ontology-driven recommendation strategies based on user's context. The strategies use ontology to describe and integrate tourism resources, achieve the goal of associating user's direct needs and his potential preference as the context in recommendation. Moreover, theoretical analysis and experiments show that the proposed approach is feasible, the results of the evaluation are discussed.
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