| 1. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 2. |
- Cheng, Lu, et al.
(författare)
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Development of compact electronic noses : a review
- 2021
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Ingår i: Measurement science and technology. - : IOP Publishing. - 0957-0233 .- 1361-6501. ; 32:6
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Forskningsöversikt (refereegranskat)abstract
- An electronic nose (e-nose) is a measuring instrument that mimics human olfaction and outputs 'fingerprint' information of mixed gases or odors. Generally speaking, an e-nose is mainly composed of two parts: a gas sensing system (gas sensor arrays, gas transmission paths) and an information processing system (microprocessor and related hardware, pattern recognition algorithms). It has been more than 30 years since the e-nose concept was introduced in the 1980s. Since then, e-noses have evolved from being large in size, expensive, and power-hungry instruments to portable, low cost devices with low power consumption. This paper reviews the development of compact e-nose design and calculation over the last few decades, and discusses possible future trends. Regarding the compact e-nose design, which is related to its size and weight, this paper mainly summarizes the development of sensor array design, hardware circuit design, gas path (i.e. the path through which the mixed gases to be measured flow inside the e-nose system) and sampling design, as well as portable design. For the compact e-nose calculation, which is directly related to its rapidity of detection, this review focuses on the development of on-chip calculation and wireless computing. The future trends of compact e-noses include the integration with the internet of things, wearable e-noses, and mobile e-nose systems.
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| 3. |
- Guo, Junlang, et al.
(författare)
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Industrial metaverse towards Industry 5.0 : Connotation, architecture, enablers, and challenges
- 2024
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 76, s. 25-42
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Forskningsöversikt (refereegranskat)abstract
- The development of any industry cannot be done without social expectations. The industrial metaverse arises from customers' emphasis on their value, their desire for immersive experiences, and their vision for untrammeled economic transactions. This paper first introduces the definition, propositions, and metrics of the industrial metaverse towards Industry 5.0. Then, based on the understanding of physical space, cyber space, and social space, this paper proposes a five-layer framework for the industrial metaverse, which covers the perception layer, networking layer, fusion layer, interaction layer, and configuration layer. Subsequently, this paper further analyzes the key enablers and potential application scenarios of the industrial metaverse towards Industry 5.0. The technical challenges at different levels and social barriers from different perspectives are discussed. Finally, this paper highlights future research directions for the industrial metaverse towards Industry 5.0. It is expected that this framework study will provide researchers with an overview of the industrial metaverse and a deeper understanding of its development potential and obstacles.
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| 4. |
- Huang, Yaqi, et al.
(författare)
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Application of the International Classification of Functioning, Disability and Health (ICF) in dementia research and practice : A scoping review
- 2023
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Ingår i: Aging & Mental Health. - : Taylor & Francis. - 1360-7863 .- 1364-6915. ; 27:2, s. 357-371
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Forskningsöversikt (refereegranskat)abstract
- OBJECTIVES: The International Classification of Functioning, Disability and Health (ICF) endorsed by the World Health Organization provides a conceptual framework for describing functioning and disability based on a biopsychosocial model. Although dementia is one of the leading causes of disability, yet little is known on the extent to how the ICF has been utilized in dementia research and practice. The study aimed to examine and map the current applications of the ICF with dementia from a body of earlier studies and to explore the potential use in person-centred dementia care.METHODS: The Arksey and O'Malley framework was used to guide the searching, selecting, and synthesizing process. The scoping review was reported following The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Review (PRISMA-ScR) guidelines.RESULTS: A total of 34 studies were included. The applications of ICF were classified into 4 themes: (1) in clinical practice and the education of health professionals (n = 20); (2) community support services and income support (n = 3); (3) population-based, census, or survey data (n = 10); (4) advocacy and empowerment purposes (n = 1).CONCLUSION: The ICF has made a major impact on dementia in clinical settings. Findings strongly support applying the ICF to person-centered dementia care. In the future, more empirical studies are needed to expand the scope of ICF use in dementia research and practice.
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| 5. |
- Luo, Yifei, et al.
(författare)
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Technology Roadmap for Flexible Sensors
- 2023
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Ingår i: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 17:6, s. 5211-5295
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Forskningsöversikt (refereegranskat)abstract
- Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.
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| 6. |
- Wang, Lu, et al.
(författare)
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The geographical distribution of grey wolves (Canis lupus) in China : a systematic review
- 2016
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Ingår i: Zoological Research. - : Science Press. - 2095-8137. ; 37:6, s. 315-326
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Forskningsöversikt (refereegranskat)abstract
- The grey wolf (Canis lupus) is one of the most widely distributed terrestrial mammals, and its distribution and ecology in Europe and North America are largely well described. However, the distribution of grey wolves in southern China is still highly controversial. Several well-known western literatures stated that there were no grey wolves in southern China, while the presence of grey wolves across China has been indicated in A Guide to the Mammals of China, published by Princeton University Press. It is essential to solve this discrepancy since dogs may have originated from grey wolves in southern China. Therefore, we systematically investigated Chinese literatures about wild animal surveys and identified more than 100 articles and books that included information of the distribution of grey wolves in China. We also surveyed the collections of three Chinese natural museums and found 26 grey wolf skins specimens collected across China. Moreover, we investigated the fossil records in China and identified 25 archaeological sites with wolf remains including south China. In conclusion, with the comprehensive summary of Chinese literatures, museum specimens and fossil records, we demonstrate that grey wolves do distribute across all parts of the Chinese mainland, including the most southern parts.
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| 7. |
- Zhang, Qi, et al.
(författare)
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Factors influencing the economics of public charging infrastructures for EV - A review
- 2018
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Ingår i: Renewable & sustainable energy reviews. - : Elsevier. - 1364-0321 .- 1879-0690. ; 94, s. 500-509
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Forskningsöversikt (refereegranskat)abstract
- Growing concerns about energy conservation and the environmental impacts of greenhouse gas emissions over the world have promoted the development of the electric vehicles (EVs) market. However, one of the biggest barriers in the development of the EV market is the lack of the public charging infrastructure. This paper reviews the factors that can directly and indirectly influence the economics of the public charging infrastructure. The knowledge gaps, barriers and opportunities in the development of the charging infrastructure have been identified and analyzed. In order to promote the development of the public charging infrastructure, more research efforts should be paid on the impacts of psychological factors of customers and the technical development of charging infrastructures and EV batteries. The government support has been proved to play an important role, so that how the government policy can be tailored for the development of the charging infrastructure market should receive more attentions. In addition, the charging price as an endogenous factor should be considered more carefully in modelling the charging infrastructure market. New business models are also urgently needed to accelerate the future development of the public charging infrastructure.
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| 8. |
- Zhao, Deqiang, 1989-, et al.
(författare)
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Research Progress on Inactivation of Bacteriophages by Visible-Light Photocatalytic Composite Materials : A Mini Review
- 2024
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Ingår i: Materials. - 1996-1944. ; 17:1
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Forskningsöversikt (refereegranskat)abstract
- Infectious diseases caused by waterborne viruses have attracted researchers’ great attention. To ensure a safe water environment, it is important to advance water treatment and disinfection technology. Photocatalytic technology offers an efficient and practical approach for achieving this goal. This paper reviews the latest studies on visible-light composite catalysts for bacteriophage inactivation, with a main focus on three distinct categories: modified UV materials, direct visible-light materials and carbon-based materials. This review gives an insight into the progress in photocatalytic material development and offers a promising solution for bacteriophage inactivation.
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