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Sökning: WFRF:(Quirós José R) > Göteborgs universitet

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1.	Gaziano, Liam, et al. (författare) Mild-to-moderate kidney dysfunction and cardiovascular disease : Observational and mendelian randomization analyses 2022 Ingår i: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 146:20, s. 1507-1517 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
2.	Moskal, Aurelie, et al. (författare) Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study. 2014 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6 Tidskriftsartikel (refereegranskat)abstract Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Tjønneland, Anne (2); Tumino, Rosario (2); Sacerdote, Carlotta (2); Amiano, Pilar (2); Riboli, Elio (2); Weiderpass, Elisabet ... (2); visa fler...; Freisling, Heinz (2); Ärnlöv, Johan, 1970- (1); Boutron-Ruault, Mari ... (1); Kaaks, Rudolf (1); Boeing, Heiner (1); Buijsse, Brian (1); Trichopoulou, Antoni ... (1); Masala, Giovanna (1); Buckland, Genevieve (1); Khaw, Kay-Tee (1); Wareham, Nick (1); Key, Timothy J (1); Hankey, Graeme J. (1); Gaziano, Thomas A. (1); Ljungberg, Börje, Pr ... (1); Drake, Isabel (1); Brenner, Hermann (1); Rosengren, Annika, 1 ... (1); Schubert, Petra (1); Arndt, Volker (1); Katzke, Verena (1); Kühn, Tilman (1); Dahm, Christina C. (1); Palli, Domenico (1); Pala, Valeria (1); Schulze, Matthias B. (1); Sieri, Sabina (1); Gurrea, Aurelio Barr ... (1); Heath, Alicia K. (1); Ericson, Ulrika (1); Kyrø, Cecilie (1); Ferrari, Pietro (1); Bamia, Christina (1); Bueno-de-Mesquita, H ... (1); Halkjaer, Jytte (1); Quiros, Jose R. (1); Melander, O. (1); Sundström, Johan, Pr ... (1); Langenberg, Claudia (1); Gaziano, J Michael (1); Dankner, Rachel (1); Baigent, Colin (1); Romaguera, Dora (1); Orfanos, Philippos (1); visa färre...

Lärosäte: Göteborgs universitet (2)Ta bort avgränsningen; Umeå universitet (2); Lunds universitet (2); Karolinska Institutet (2); Uppsala universitet (1); Högskolan Dalarna (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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