Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study

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Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study

Bhatt, Deepak L. (author): Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

Fox, Kim (author): Imperial Coll, Natl Heart & Lung Inst, London, England;Royal Brompton Hosp, London, England

Harrington, Robert A. (author): Stanford Univ, Dept Med, SCCR, Stanford, CA 94305 USA

Leiter, Lawrence A. (author): Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

Mehta, Shamir R. (author): Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;McMaster Univ, Hamilton, ON, Canada

Simon, Tabassome (author): Sorbonne Univ Paris, Hop St Antoine, AP HP, Dept Clin Pharmacol URCEST, Paris, France

Andersson, Marielle (author): AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden

Himmelmann, Anders (author): AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden

Ridderstrale, Wilhelm (author): AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden

Held, Claes, 1956- (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Uppsala Clin Res Ctr, Dept Med Sci, Cardiol, Uppsala, Sweden

Steg, Philippe Gabriel (author): Univ Paris Diderot, Hop Bichat, AP HP, Dept Hosp Univ FIRE,F CRIN Network,FACT, Paris, France;Univ Paris Diderot, Hop Bichat, AP HP, Dept Hosp Univ FIRE,INSERM,U 1148, Paris, France;Imperial Coll, Royal Brompton Hosp, NHLI, London, England

Steg, Gabriel (author)

Diaz, Rafael (author)

Amerena, John (author)

Huber, Kurt (author)

Sinnaeve, Peter (author)

Nicolau, Jose Carlos (author)

Kerr Saraiva, Jose Francisco (author)

Petrov, Ivo (author)

Corbalan, Ramon (author)

Ge, Junbo (author)

Zhao, Qiang (author)

Botero, Rodrigo (author)

Widimsky, Petr (author)

Kristensen, Steen Dalby (author)

Hartikainen, Juha (author)

Danchin, Nicolas (author)

Darius, Harald (author)

Fat, Tse Hung (author)

Kiss, Robert Gabor (author)

Pais, Prem (author)

Lev, Eli (author)

De Luca, Leonardo (author)

Goto, Shinya (author)

Ramos Lopez, Gabriel Arturo (author)

Cornel, Jan Hein (author)

Kontny, Frederic (author)

Medina, Felix (author)

Babilonia, Noe (author)

Opolski, Grzegorz (author)

Vinereanu, Dragos (author)

Zateyshchikov, Dmitry (author)

Ruda, Mikhail (author)

Elamin, Omer (author)

Kovar, Frantisek (author)

Dalby, Anthony John (author)

Jeong, Myung Ho (author)

Bueno, Hector (author)

James, Stefan (author)

Chiang, Chern-En (author)

Tresukosol, Damras (author)

Ongen, Zeki (author)

Ray, Kausik (author)

Parkhomenko, Alexander (author)

McGuire, Darren (author)

Kosiborod, Mikhail (author)

Nguyen, Tuan Quang (author)

Wallentin, Lars (author)

Fox, Keith A. A. (author)

Eikelboom, John W. (author)

Tuomilehto, Jaakko (author)

Lee, Kerry L. (author)

Al-Khalidi, Hussein R. (author)

Ellis, Stephen J. (author)

Hagström, Emil (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Holmgren, Pernilla (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Heldestad, Ulrika (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Hallberg, Theresa (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Renlund Grausne, Karin (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Alm, Cristina (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Michelgård Palmquist, Åsa, 1973- (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Svanberg, Camilla (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Capell, Warren H. (author)

Nehler, Mark R. (author)

Hiatt, William R. (author)

Bonaca, Marc P. (author)

Houser, Stacey (author)

Bachler, Susie (author)

Jaeger, Nicole (author)

Aunes, Maria (author)

Brusehed, Asa (author)

Chen, Jersey (author)

Dahlof, Bjorn (author)

Dolezalova, Jitka (author)

Domzol, Maciej (author)

Findley, Magdalena (author)

Holmberg, Niclas (author)

Jahreskog, Marianne (author)

Knutsson, Mikael (author)

Kruszewski, Jakub (author)

Leonsson-Zachrisson, Maria (author)

Stark, Maj (author)

Winder, Elin (author)

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(creator_code:org_t)

2019-04-09
2019
English.
In: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 42:5, s. 498-505

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://onlinelibrar...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.

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By the author/editor: Bhatt, Deepak L.; Fox, Kim; Harrington, Robe ...; Leiter, Lawrence ...; Mehta, Shamir R.; Simon, Tabassome; show more...; Andersson, Marie ...; Himmelmann, Ande ...; Ridderstrale, Wi ...; Held, Claes, 195 ...; Steg, Philippe G ...; Steg, Gabriel; Diaz, Rafael; Amerena, John; Huber, Kurt; Sinnaeve, Peter; Nicolau, Jose Ca ...; Kerr Saraiva, Jo ...; Petrov, Ivo; Corbalan, Ramon; Ge, Junbo; Zhao, Qiang; Botero, Rodrigo; Widimsky, Petr; Kristensen, Stee ...; Hartikainen, Juh ...; Danchin, Nicolas; Darius, Harald; Fat, Tse Hung; Kiss, Robert Gab ...; Pais, Prem; Lev, Eli; De Luca, Leonard ...; Goto, Shinya; Ramos Lopez, Gab ...; Cornel, Jan Hein; Kontny, Frederic; Medina, Felix; Babilonia, Noe; Opolski, Grzegor ...; Vinereanu, Drago ...; Zateyshchikov, D ...; Ruda, Mikhail; Elamin, Omer; Kovar, Frantisek; Dalby, Anthony J ...; Jeong, Myung Ho; Bueno, Hector; James, Stefan; Chiang, Chern-En; Tresukosol, Damr ...; Ongen, Zeki; Ray, Kausik; Parkhomenko, Ale ...; McGuire, Darren; Kosiborod, Mikha ...; Nguyen, Tuan Qua ...; Wallentin, Lars; Fox, Keith A. A.; Eikelboom, John ...; Tuomilehto, Jaak ...; Lee, Kerry L.; Al-Khalidi, Huss ...; Ellis, Stephen J ...; Hagström, Emil; Holmgren, Pernil ...; Heldestad, Ulrik ...; Hallberg, Theres ...; Renlund Grausne, ...; Alm, Cristina; Michelgård Palmq ...; Svanberg, Camill ...; Capell, Warren H ...; Nehler, Mark R.; Hiatt, William R ...; Bonaca, Marc P.; Houser, Stacey; Bachler, Susie; Jaeger, Nicole; Aunes, Maria; Brusehed, Asa; Chen, Jersey; Dahlof, Bjorn; Dolezalova, Jitk ...; Domzol, Maciej; Findley, Magdale ...; Holmberg, Niclas; Jahreskog, Maria ...; Knutsson, Mikael; Kruszewski, Jaku ...; Leonsson-Zachris ...; Stark, Maj; Winder, Elin; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Clinical Cardiol ...

By the university: Uppsala University

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Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study

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