Search: WFRF:(Rappuoli R)
> Sankala M >
SR-A, MARCO and TLR...
SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors
-
Pluddemann, A (author)
-
Mukhopadhyay, S (author)
-
Sankala, M (author)
-
show more...
-
Savino, S (author)
-
Pizza, M (author)
-
Rappuoli, R (author)
-
- Tryggvason, K (author)
- Karolinska Institutet
-
Gordon, S (author)
-
show less...
-
(creator_code:org_t)
- 2008-09-11
- 2009
- English.
-
In: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 1:2, s. 153-163
- Related links:
-
https://www.karger.c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Macrophages express various classes of pattern recognition receptors involved in innate immune recognition of artificial, microbial and host-derived ligands. These include the scavenger receptors (SRs), which are important for phagocytosis, and the Toll-like receptors (TLRs) involved in microbe sensing. The class A macrophage scavenger receptor (SR-A) and macrophage receptor with a collagenous structure (MARCO) display similar domain structures and ligand-binding specificity, which has led to the assumption that these two receptors may be functionally redundant. In this study we show that SR-A and MARCO differentially recognise artificial polyanionic ligands as well as surface proteins from the pathogenic bacterium <i>Neisseria meningitidis</i>. We show that, while acetylated low-density lipoprotein (AcLDL) is a strong ligand for SR-A, it is not a ligand for MARCO. Of the neisserial proteins that were SR ligands, some were ligands for both receptors, while other proteins were only recognised by either SR-A or MARCO. We also analysed the potential of these ligands to act as TLR agonists and assessed the requirement for SR-A and MARCO in pro-inflammatory cytokine induction. SR ligation alone did not induce cytokine production; however, for proteins that were both SR and TLR ligands, the SRs were required for full activation of TLR pathways.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database