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Sökning: WFRF:(Rekha P)

  • Resultat 1-10 av 27
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  • Niemi, MEK, et al. (författare)
  • 2021
  • swepub:Mat__t
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  • Abbafati, Cristiana, et al. (författare)
  • 2020
  • Tidskriftsartikel (refereegranskat)
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  • Ahmed, S, et al. (författare)
  • Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation
  • 2020
  • Ingår i: Antibiotics (Basel, Switzerland). - : MDPI AG. - 2079-6382. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated with poor patient compliance, which in turn, may contribute to the emergence of multi-drug resistant TB (MDR-TB). The low global treatment efficacy of MDR-TB has highlighted the necessity to develop novel treatment options. Host-directed therapy (HDT) together with current standard anti-TB treatments, has gained considerable interest, as HDT targets novel host immune mechanisms. These immune mechanisms would otherwise bypass the antibiotic bactericidal targets to kill Mycobacterium tuberculosis (Mtb), which may be mutated to cause antibiotic resistance. Additionally, host-directed therapies against TB have been shown to be associated with reduced lung pathology and improved disease outcome, most likely via the modulation of host immune responses. This review will provide an update of host-directed therapies and their mechanism(s) of action against Mycobacterium tuberculosis.
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  • Banik, Trisanu, et al. (författare)
  • Understanding dynamics of tropical cyclones in the Bay of Bengal using lightning data
  • 2021
  • Ingår i: Meteorology and atmospheric physics (Print). - : Springer Nature. - 0177-7971 .- 1436-5065. ; 133:5, s. 1505-1522
  • Tidskriftsartikel (refereegranskat)abstract
    • In the present work, we are studying the dynamics of 11 tropical cyclones (TCs) over the Bay of Bengal (BoB) using the World Wide Lightning Location Network (WWLLN) lightning data during 2013–2017. Detailed investigation of Lightning Stroke Count (LSC) shows that the initial phase of the TC intensification over BoB is associated with high lightning activity both in the eye region and rainband region. The study of different category TCs shows the weak and moderate-intensity TCs during both in pre-monsoon and post-monsoon seasons are lightning populated (specifically inner bands) during and prior to the intensification phase. Peak Maximum Sustained Wind Speed (MSWS), which is linked to sea surface temperatures (SSTs), is preceded by the peak LSC with a time lag of 6–12 h. The LSC peaks in the eye region and rain band for different categories of TCs between small to moderate wind shear range. The present study highlights that the monitoring of real-time lightning activity could provide supportive information on the existing forecast techniques. But further analyses are required over BoB to quantify the relationship between TC intensification and lightning activity both in space and time.
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