Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: An individual-based pooled analysis of 40 twin cohorts

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Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : An individual-based pooled analysis of 40 twin cohorts

Silventoinen, K. (author): Departments of Social Research, Research Programs Unit, University of Helsinki, Helsinki, Finland; Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

Jelenkovic, A. (author)

Sund, R. (author)

Yokoyama, Y. (author)

Hur, Y. -M (author)

Cozen, W. (author)

Hwang, A. E. (author)

Mack, T. M. (author)

Honda, C. (author)

Inui, F. (author)

Iwatani, Y. (author)

Watanabe, M. (author)

Tomizawa, R. (author)

Pietilainen, K. H. (author)

Rissanen, A. (author)

Siribaddana, S. H. (author)

Hotopf, M. (author)

Sumathipala, A. (author)

Rijsdijk, F. (author)

Tan, Q. (author)

Zhang, D. (author)

Pang, Z. (author)

Piirtola, M. (author): Karolinska Institutet

Aaltonen, S. (author)

Oncel, S. Y. (author)

Aliev, F. (author)

Rebato, E. (author)

Hjelmborg, J. B. (author)

Christensen, K. (author)

Skytthe, A. (author)

Kyvik, K. O. (author)

Silberg, J. L. (author)

Eaves, L. J. (author)

Cutler, T. L. (author)

Ordonana, J. R. (author)

Sanchez-Romera, J. F. (author)

Colodro-Conde, L. (author)

Song, Y. -M (author)

Yang, S. (author)

Lee, K. (author)

Franz, C. E. (author)

Kremen, W. S. (author)

Lyons, M. J. (author)

Busjahn, A. (author)

Nelson, T. L. (author)

Whitfield, K. E. (author)

Kandler, C. (author)

Jang, K. L. (author)

Gatz, M. (author)

Butler, D. A. (author)

Stazi, M. A. (author)

Fagnani, C. (author)

D'Ippolito, C. (author)

Duncan, G. E. (author)

Buchwald, D. (author)

Martin, N. G. (author)

Medland, S. E. (author)

Montgomery, G. W. (author)

Jeong, H. -U (author)

Swan, G. E. (author)

Krasnow, R. (author)

Magnusson, P. K. E. (author)

Pedersen, N. L. (author): Karolinska Institutet

Dahl Aslan, Anna K., 1975- (author): Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Departments of Social Research, Research Programs Unit, University of Helsinki, Helsinki, Finland,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ; Institute of Gerontology and Aging Research Network–Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden

McAdams, T. A. (author)

Tuvblad, Catherine, 1968- (author): Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Department of Psychology, University of Southern California, Los Angeles CA, United States

Gregory, A. M. (author)

Tynelius, P. (author): Karolinska Institutet

Baker, L. A. (author)

Tuvblad, C. (author)

Bayasgalan, G. (author)

Narandalai, D. (author)

Spector, T. D. (author)

Mangino, M. (author)

Lachance, G. (author)

Burt, S. A. (author)

Klump, K. L. (author)

Harris, J. R. (author)

Brandt, I. (author)

Nilsen, T. S. (author)

Krueger, R. F. (author)

McGue, M. (author)

Pahlen, S. (author)

Corley, R. P. (author)

Huibregtse, B. M. (author)

Bartels, M. (author)

Van Beijsterveldt, C. E. M. (author)

Willemsen, G. (author)

Goldberg, J. H. (author)

Rasmussen, F. (author)

Tarnoki, A. D. (author)

Tarnoki, D. L. (author)

Derom, C. A. (author)

Vlietinck, R. F. (author)

Loos, R. J. F. (author)

Hopper, J. L. (author)

Sung, J. (author)

Maes, H. H. (author)

Turkheimer, E. (author)

Boomsma, D. I. (author)

Sørensen, T. I. A. (author)

Kaprio, J. (author): Departments of Public Health, Research Programs Unit, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine, Helsinki, Finland

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(creator_code:org_t)

Oxford University Press, 2017
2017
English.
In: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 106:2, s. 457-466

Related links:: https://academic.oup...; show more...; https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs).Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI.Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.

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By the author/editor: Silventoinen, K.; Jelenkovic, A.; Sund, R.; Yokoyama, Y.; Hur, Y. -M; Cozen, W.; show more...; Hwang, A. E.; Mack, T. M.; Honda, C.; Inui, F.; Iwatani, Y.; Watanabe, M.; Tomizawa, R.; Pietilainen, K. ...; Rissanen, A.; Siribaddana, S. ...; Hotopf, M.; Sumathipala, A.; Rijsdijk, F.; Tan, Q.; Zhang, D.; Pang, Z.; Piirtola, M.; Aaltonen, S.; Oncel, S. Y.; Aliev, F.; Rebato, E.; Hjelmborg, J. B.; Christensen, K.; Skytthe, A.; Kyvik, K. O.; Silberg, J. L.; Eaves, L. J.; Cutler, T. L.; Ordonana, J. R.; Sanchez-Romera, ...; Colodro-Conde, L ...; Song, Y. -M; Yang, S.; Lee, K.; Franz, C. E.; Kremen, W. S.; Lyons, M. J.; Busjahn, A.; Nelson, T. L.; Whitfield, K. E.; Kandler, C.; Jang, K. L.; Gatz, M.; Butler, D. A.; Stazi, M. A.; Fagnani, C.; D'Ippolito, C.; Duncan, G. E.; Buchwald, D.; Martin, N. G.; Medland, S. E.; Montgomery, G. W ...; Jeong, H. -U; Swan, G. E.; Krasnow, R.; Magnusson, P. K. ...; Pedersen, N. L.; Dahl Aslan, Anna ...; McAdams, T. A.; Tuvblad, Catheri ...; Gregory, A. M.; Tynelius, P.; Baker, L. A.; Tuvblad, C.; Bayasgalan, G.; Narandalai, D.; Spector, T. D.; Mangino, M.; Lachance, G.; Burt, S. A.; Klump, K. L.; Harris, J. R.; Brandt, I.; Nilsen, T. S.; Krueger, R. F.; McGue, M.; Pahlen, S.; Corley, R. P.; Huibregtse, B. M ...; Bartels, M.; Van Beijsterveld ...; Willemsen, G.; Goldberg, J. H.; Rasmussen, F.; Tarnoki, A. D.; Tarnoki, D. L.; Derom, C. A.; Vlietinck, R. F.; Loos, R. J. F.; Hopper, J. L.; Sung, J.; Maes, H. H.; Turkheimer, E.; Boomsma, D. I.; Sørensen, T. I. ...; Kaprio, J.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

Articles in the publication: American Journal ...

By the university: Jönköping University; Örebro University; University of Skövde; Karolinska Institutet

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Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : An individual-based pooled analysis of 40 twin cohorts

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