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Galectin-3 Expressi...
Abstract
Ämnesord
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- Background: In nodal anaplastic large cell lymphoma, strong expression of galectin-3 (Gal-3) has been found, but only very few cases of primary cutaneous lymphoma have so far been examined. Objectives: To investigate 11 primary cutaneous anaplastic large cell lymphomas (PCALCL), 47 lymphomatoid papuloses (LYP) and 14 cases of transformed mycosis fungoides with CD30 expression (MF-T) for Gal-3 expression. Methods: A Gal-3 score was applied using a photo-based morphometric evaluation program. Double staining for CD30 and Gal-3 was performed. Furthermore, we recorded the cellular and extracellular sublocalization of the signal. Results: The Gal-3 expression in CD30+ tumor cells was significantly lower in MF-T in contrast to CD30+ lymphoproliferative disorders (CD30 LPD; p < 0.001), but we found no differences between PCALCL and LYP (p = 0.42). In PCALCL Gal-3 was more often localized in the cytoplasm in contrast to LYP, in which an equal distribution in the cytoplasm and the nucleus was more common (p = 0.9). Conclusions: The lower Gal-3 expression in MF-T in comparison to CD30 LPD might be an additional criterion to differentiate both entities. The different sublocalization of the Gal-3 signal might reflect a different biological function and behavior. © 2015 S. Karger AG, Basel.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- anaplastic lymphoma kinase
- CD30 antigen
- epithelial membrane antigen
- galectin 3
- CD30 antigen
- galectin 3
- galectin-3
- human
- adult
- antigen expression
- Article
- cell nucleus
- cellular distribution
- controlled study
- cytoplasm
- dendritic cell
- female
- histology
- human
- human tissue
- immunohistochemistry
- large cell lymphoma
- lymphocytic infiltration
- lymphomatoid papulosis
- macrophage
- male
- mycosis fungoides
- practice guideline
- primary cutaneous anaplastic large cell lymphoma
- priority journal
- protein expression
- protein localization
- signal transduction
- skin biopsy
- skin lymphoma
- tumor cell
- adolescent
- aged
- chemistry
- child
- cutaneous T cell lymphoma
- large cell lymphoma
- metabolism
- middle aged
- mycosis fungoides
- pathology
- skin tumor
- very elderly
- young adult
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Antigens
- CD30
- Cell Nucleus
- Child
- Cytoplasm
- Female
- Galectin 3
- Humans
- Lymphoma
- Primary Cutaneous Anaplastic Large Cell
- Lymphoma
- T-Cell
- Cutaneous
- Lymphomatoid Papulosis
- Male
- Middle Aged
- Mycosis Fungoides
- Skin Neoplasms
- Young Adult
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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