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Failure of Transpla...
Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic β-Cell Fate
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- Taneera, Jalal (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - öpatofysiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Islet Patophysiology,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
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- Rosengren, Anders (författare)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Department of Physiological Sciences, Lund University, Lund, Sweden
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- Renström, Erik (författare)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Department of Physiological Sciences, Lund University, Lund, Sweden
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- Nygren, Jens Martin, 1976- (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Immunologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Immunology,Lund University Research Groups,Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
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- Serup, Palle (författare)
- Department of Developmental Biology, Hagedorn Research Institute, Copenhagen, Denmark
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- Rorsman, Patrik (författare)
- Lund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Department of Physiological Sciences, Lund University, Lund, Sweden
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- Jacobsen, Sten Eirik W (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematopoietic Stem Cell Laboratory, Lund University, BMC, B10, SE-221 84 Lund, Sweden
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(creator_code:org_t)
- Alexandria, USA : American Diabetes Association, 2006
- 2006
- Engelska.
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Ingår i: Diabetes. - Alexandria, USA : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:2, s. 290-296
- Relaterad länk:
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http://diabetes.diab...
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Recent studies in normal mice have suggested that transplanted bone marrow cells can transdifferentiate into pancreatic beta-cells at relatively high efficiency. Herein, adopting the same and alternative approaches to deliver and fate map-transplanted bone marrow cells in the pancreas of normal as well as diabetic mice, we further investigated the potential of bone marrow transplantation as an alternative approach for beta-cell replacement. In contrast to previous studies, transplanted bone marrow cells expressing green fluorescence protein (GFP) under the control of the mouse insulin promoter failed to express GFP in the pancreas of normal as well as diabetic mice. Although bone marrow cells expressing GFP under the ubiquitously expressed beta-actin promoter efficiently engrafted the pancreas of normal and hyperglycemic mice, virtually all expressed CD45 and Mac-1/Gr-1, demonstrating that they adopt a hematopoietic rather than beta-cell fate, a finding further substantiated by the complete absence of GFP(+) cells expressing insulin and the beta-cell transcription factors pancreatic duodenal homeobox factor-1 and homeodomain protein. Thus, transplanted bone marrow cells demonstrated little, if any, capacity to adopt a beta-cell fate.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- hematopoietic stem-cells
- insulin-producing cells
- glucagon-like peptide-1
- in-vivo
- purkinje neurons
- fusion
- mice
- muscle
- transdifferentiation
- hepatocytes
- Diabetology
- Diabetologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Diabetes
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