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Therapygenetic effe...
Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders : A meta-analysis
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- Schiele, Miriam A. (author)
- Univ Freiburg, Germany
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- Reif, Andreas (author)
- Univ Hosp Frankfurt, Germany
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- Lin, Jiaxi (author)
- Univ Freiburg, Germany
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- Alpers, Georg W. (author)
- Univ Mannheim, Germany
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- Andersson, Evelyn (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Andersson, Gerhard, Fil dr, Med dr, 1966- (author)
- Linköpings universitet,Karolinska Institutet,Psykologi,Filosofiska fakulteten
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- Arolt, Volker (author)
- Univ Munster, Germany
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- Bergström, Jan (author)
- Stockholms universitet,Klinisk psykologi
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- Carlbring, Per (author)
- Stockholms universitet,Klinisk psykologi
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- Eley, Thalia C. (author)
- Kings Coll London, England
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- Esquivel, Gabriel (author)
- Maastricht Univ, Netherlands
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Gerlach, Alexander L. (author)
- Univ Cologne, Germany
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- Hamm, Alfons (author)
- Ernst Moritz Arndt Univ Greifswald, Germany
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- Helbig-Lang, Sylvia (author)
- Univ Hamburg, Germany
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- Hudson, Jennifer L. (author)
- Macquarie Univ, Australia
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- Lang, Thomas (author)
- Christoph Dornier Fdn Clin Psychol, Germany; Jacobs Univ Bremen, Germany
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- Lester, Kathryn J. (author)
- Univ Sussex, England
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- Lindefors, Nils (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden
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- Lonsdorf, Tina B. (author)
- Univ Med Ctr Hamburg Eppendorf, Germany
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- Pauli, Paul (author)
- Julius Maximilians Univ Wurzburg, Germany; Julius Maximilians Univ Wurzburg, Germany
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- Richter, Jan (author)
- Ernst Moritz Arndt Univ Greifswald, Germany,Maastricht Univ, Netherlands
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- Rief, Winfried (author)
- Philipps Univ Marburg, Germany
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- Roberts, Susanna (author)
- Kings Coll London, England
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- Rück, Christian (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden
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Schruers, Koen R.J. (author)
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- Thiel, Christiane (author)
- Univ Freiburg, Germany
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- Wittchen, Hans-Ulrich (author)
- Tech Univ Dresden, Germany
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- Domschke, Katharina (author)
- Univ Freiburg, Germany; Univ Freiburg, Germany
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- Weber, Heike (author)
- Univ Hosp Frankfurt, Germany; Univ Hosp Wurzburg, Germany
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- Lueken, Ulrike (author)
- Univ Hosp Wurzburg, Germany; Humboldt Univ, Germany
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: European Neuropsychopharmacology. - : Elsevier. - 0924-977X .- 1873-7862. ; 44, s. 105-120
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Serotonin transporter gene
- Therapygenetics
- Treatment response
- Therapy outcome
- CBT
- Panic disorder
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Schiele, Miriam ...
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Reif, Andreas
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Lin, Jiaxi
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Alpers, Georg W.
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Andersson, Evely ...
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Andersson, Gerha ...
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show more...
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Arolt, Volker
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Bergström, Jan
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Carlbring, Per
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Eley, Thalia C.
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Esquivel, Gabrie ...
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Furmark, Tomas
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Gerlach, Alexand ...
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Hamm, Alfons
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Helbig-Lang, Syl ...
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Hudson, Jennifer ...
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Lang, Thomas
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Lester, Kathryn ...
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Lindefors, Nils
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Lonsdorf, Tina B ...
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Pauli, Paul
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Richter, Jan
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Rief, Winfried
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Roberts, Susanna
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Rück, Christian
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Schruers, Koen R ...
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Thiel, Christian ...
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Wittchen, Hans-U ...
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Domschke, Kathar ...
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Weber, Heike
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Lueken, Ulrike
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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European Neurops ...
- By the university
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Uppsala University
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Karolinska Institutet
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Linköping University
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Stockholm University