| 1. |
- Yaghootkar, Hanieh, et al.
(författare)
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Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
- 2020
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2806-2818
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Tidskriftsartikel (refereegranskat)abstract
- Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
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| 2. |
- Chelgani, Saeed Chehreh, et al.
(författare)
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A review of rare earth minerals flotation : Monazite and xenotime
- 2015
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Ingår i: International Journal of Mining Science and Technology. - : Elsevier. - 2095-2686. ; 25:6, s. 877-883
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Tidskriftsartikel (refereegranskat)abstract
- This paper reviews rare earth minerals (monazite and xenotime) separation by flotation. A wide range of monazite and xenotime flotation test results are summarized including: reasons of variation in the point of zero charges on these minerals, the effects of various flotation conditions on zeta potential of monazite and xenotime, interactions of collectors and depressants on the surface of these minerals during flotation separation, relationship between surface chemistry of the minerals and different types of collector adsorptions and effects of the conditioning temperature on flotation of rare earth minerals. This review collects various approaches for the selective separation of monazite and xenotime by flotation and gives perspectives for further research in the future.
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| 3. |
- Chelgani, Saeed Chehreh, et al.
(författare)
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Study of the relationship between zinnwaldite chemical composition and magnetic susceptibility
- 2015
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Ingår i: Minerals Engineering. - : Elsevier. - 0892-6875 .- 1872-9444. ; 72, s. 27-30
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates the relationship between chemical analyses and magnetic susceptibility of zinnwaldite through magnetic separation of various size fractions. Statistical analyses were used to increase information about magnetic properties of this mineral as a future source of lithium. Statistical modeling indicated that magnetic susceptibility (as a main factor of magnetic separation) accurately can be predicted based on cations content of zinnwaldite. However the size of particles had a significant effect on magnetic susceptibility. The small difference between the estimated and measured values for the non-linear relationship of this prediction (less than 1 (10−8 m3/kg)) shows that these accurate theoretical techniques can be also applied to estimate magnetic properties of zinnwaldite in other resources, and in-situ analysis.
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| 4. |
- Leistner, T., et al.
(författare)
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A study of the reprocessing of fine and ultrafine cassiterite from gravity tailing residues by using various flotation techniques
- 2016
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Ingår i: Minerals Engineering. - : Elsevier. - 0892-6875 .- 1872-9444. ; 96-97, s. 94-98
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates the reprocessing of once disposed tin tailings from a historic German tin operation through different surface properties based processing techniques. Froth flotation and agglomeration flotation, by using commercially available cassiterite collectors from Clariant, were chosen as processing techniques. Isooctane as a nonpolar oil was used to promote the collection of ultrafine (−10 μm) cassiterite by selective agglomeration, and thus, size enlargement. Results indicate that by using sulfosuccinamates as a collector, around 80% of the fine (−50 μm) to very fine (−20 μm) cassiterite can be recovered (representing ∼50% of the total cassiterite in the tailings sample). Agglomeration flotation experiments showed inferior results for recovering the ultrafine cassiterite (for feed fractions in the −25 μm size range). Oil/froth interaction and increased pulp ion content are considered as the main contributing causes.
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