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Reduced Corneal Ner...
Reduced Corneal Nerve Fiber Density in Type 2 Diabetes by Wide-Area Mosaic Analysis
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- Lagali, Neil S, 1973- (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Allgeier, Stephan (author)
- Karlsruhe Inst Technol, Inst Appl Comp Sci, Karlsruhe, Germany.,Institute for Applied Computer Science, Karlsruhe Institute of Technology, Karlsruhe, Germany
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- Guimaraes, Pedro (author)
- Univ Padua, Dept Informat Engn, Padua, Italy.,Department of Information Engineering, University of Padova, Padova, Italy
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- Badian, Reza A. (author)
- Univ Coll Southeast Norway, Fac Hlth Sci, Kongsberg, Norway.;Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway.;Univ Bergen, Stavanger Univ Hosp, Fac Med, Stavanger Clin Inst 1,Dept Ophthalmol, Bergen, Norway.,Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Department of Ophthalmology, Stavanger University Hospital, Stavanger/Clinical Institute 1, Faculty of Medicine, University of Bergen, Bergen, Norway,Oslo university hospital
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- Ruggeri, Alfredo (author)
- Univ Padua, Dept Informat Engn, Padua, Italy.,Department of Information Engineering, University of Padova, Padova, Italy
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- Koehler, Bernd (author)
- Karlsruhe Inst Technol, Inst Appl Comp Sci, Karlsruhe, Germany.,Institute for Applied Computer Science, Karlsruhe Institute of Technology, Karlsruhe, Germany
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- Utheim, Tor Paaske (author)
- Univ Coll Southeast Norway, Fac Hlth Sci, Kongsberg, Norway.;Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway.,Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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- Peebo, Beatrice, 1968- (author)
- Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Peterson, Magnus, 1966- (author)
- Uppsala University,Uppsala universitet,Allmänmedicin och preventivmedicin,Department of Public Health and Caring Sciences, Section of Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden
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- Dahlin, Lars B. (author)
- Lund University,Lunds universitet,Handkirurgi, Malmö,Forskargrupper vid Lunds universitet,Hand Surgery, Malmö,Lund University Research Groups,Department of Translational Medicine-Hand Surgery, Lund University, Skåne University Hospital, Malmö, Sweden
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- Rolandsson, Olov (author)
- Umeå University,Umeå universitet,Allmänmedicin,Umea Univ, Dept Publ Hlth & Clin Med, Sect Family Med, Umea, Sweden.,Department of Public Health and Clinical Medicine, Section of Family Medicine, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- The Assocation for Research in Vision and Ophthalmology, 2017
- 2017
- English.
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In: Investigative Ophthalmology and Visual Science. - : The Assocation for Research in Vision and Ophthalmology. - 0146-0404 .- 1552-5783. ; 58:14, s. 6318-6327
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https://doi.org/10.1...
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https://doi.org/10.6...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE. To determine if corneal subbasal nerve plexus (SBP) parameters derived from wide-area depth-corrected mosaic images are associated with type 2 diabetes.METHODS. One hundred sixty-three mosaics were produced from eyes of 82 subjects by laser-scanning in vivo confocal microscopy (IVCM). Subjects were of the same age, without (43 subjects) or with type 2 diabetes (39 subjects). Mosaic corneal nerve fiber length density (mCNFL) and apical whorl corneal nerve fiber length density (wCNFL) were quantified and related to the presence and duration of diabetes (short duration < 10 years and long duration ≥10 years).RESULTS. In mosaics with a mean size of 6 mm2 in subjects aged 69.1 ± 1.2 years, mCNFL in type 2 diabetes was reduced relative to nondiabetic subjects (13.1 ± 4.2 vs. 15.0 ± 3.2 mm/mm2, P = 0.018). Also reduced relative to nondiabetic subjects was mCNFL in both short-duration (14.0 ± 4.0 mm/mm2, 3.2 ± 3.9 years since diagnosis) and long-duration diabetes (12.7 ± 4.2 mm/mm2, 15.4 ± 4.2 years since diagnosis; ANOVA P =0.023). Lower mCNFL was associated with presence of diabetes (P =0.032) and increased hemoglobin A1c (HbA1c) levels (P = 0.047). By contrast, wCNFL was unaffected by diabetes or HbA1c (P > 0.05). Global SBP patterns revealed marked degeneration of secondary nerve fiber branches outside the whorl region in long-duration diabetes.CONCLUSIONS. Wide-area mosaic images provide reference values for mCNFL and wCNFL and reveal a progressive degeneration of the SBP with increasing duration of type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- confocal microscopy
- corneal nerves
- subbasal nerve
- diabetes mellitus
- Confocal microscopy
- Corneal nerves
- Diabetes mellitus
- Subbasal nerve
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lagali, Neil S, ...
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Allgeier, Stepha ...
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Guimaraes, Pedro
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Badian, Reza A.
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Ruggeri, Alfredo
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Koehler, Bernd
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Utheim, Tor Paas ...
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Peebo, Beatrice, ...
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Peterson, Magnus ...
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Dahlin, Lars B.
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Rolandsson, Olov
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Investigative Op ...
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Umeå University
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Uppsala University
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Lund University
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Linköping University