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1.	Lautner, Ronald, et al. (author) Apolipoprotein e genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease. 2014 In: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 71:10, s. 1183-91 Journal article (peer-reviewed)abstract Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
2.	Nabers, Andreas, et al. (author) Amyloid blood biomarker detects Alzheimer's disease 2018 In: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 10:5 Journal article (peer-reviewed)abstract Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages would be crucial for future therapy. Diagnostic tools for detection of AD are either invasive like cerebrospinal fluid (CSF) biomarkers or expensive such as positron emission tomography (PET) scanning. Here, we determine the secondary structure change of amyloid-β (Aβ) in human blood. This change used as blood amyloid biomarker indicates prodromal AD and correlates with CSF AD biomarkers and amyloid PET imaging in the cross-sectional BioFINDER cohort. In a further population-based longitudinal cohort (ESTHER), the blood biomarker detected AD several years before clinical diagnosis in baseline samples with a positive likelihood ratio of 7.9; that is, those who were diagnosed with AD over the years were 7.9 times more likely to test positive. This assay may open avenues for blood screening of early AD stages as a funnel for further more invasive and expensive tests.
3.	Schneider, Philine, et al. (author) Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment. 2011 In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 70:2, s. 145-51 Journal article (peer-reviewed)abstract Hypertension is a major risk factor of Alzheimer's disease (AD); however, controlled studies on the effect of antihypertensive treatment on the risk of dementia are inconclusive. Therefore, a biological marker that predicts individual response to antihypertensive treatment would be of high clinical relevance. Midregional proatrial natriuretic peptide (MR-proANP), an inactive surrogate molecule of the mature atrial natriuretic peptide, is related to circulatory function and hypertension.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Hansson, Oskar (3); Rujescu, Dan (3); Blennow, Kaj, 1958 (2); Minthon, Lennart (2); Zetterberg, Henrik, ... (2); Hampel, Harald (2); show more...; Wallin, Anders, 1950 (1); Landén, Mikael, 1966 (1); Brenner, Hermann (1); Janelidze, Shorena (1); Holleczek, Bernd (1); Olsson, Bob, 1969 (1); Palmqvist, Sebastian (1); Ewers, Michael (1); Andreasson, Ulf, 196 ... (1); Lautner, Ronald (1); Mattsson, Niklas, 19 ... (1); Buerger, Katharina (1); Teipel, Stefan (1); Mons, Ute (1); Saum, Kai-Uwe (1); Bergmann, Andreas (1); Herukka, Sanna-Kaisa (1); Jakobsson, Joel (1); Hartmann, Oliver (1); Pålsson, Erik, 1975 (1); Uspenskaya, Olga (1); Moeller, Hans-Juerge ... (1); Ernst, Andrea (1); Gerwert, Klaus (1); Owenius, Rikard (1); Schartner, Jonas (1); Perna, Laura (1); Nabers, Andreas (1); Lange, Julia (1); Güldenhaupt, Jörn (1); Schneider, Philine (1); show less...

University: Lund University (3)Undo refine; University of Gothenburg (2); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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