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Convergent genetic and expression data implicate immunity in Alzheimer's disease

Jones, Lesley (author)
Lambert, Jean-Charles (author)
Wang, Li-San (author)
show more...
Choi, Seung-Hoan (author)
Harold, Denise (author)
Vedernikov, Alexey (author)
Escott-Price, Valentina (author)
Stone, Timothy (author)
Richards, Alexander (author)
Bellenguez, Celine (author)
Ibrahim-Verbaas, Carla A. (author)
Naj, Adam C. (author)
Sims, Rebecca (author)
Gerrish, Amy (author)
Jun, Gyungah (author)
Lannfelt, Lars (author)
Uppsala universitet,Geriatrik
Bis, Joshua C. (author)
Beecham, Gary W. (author)
Grenier-Boley, Benjamin (author)
Russo, Giancarlo (author)
Thornton-Wells, Tricia A. (author)
Jones, Nicola (author)
Smith, Albert V. (author)
Chouraki, Vincent (author)
Thomas, Charlene (author)
Ikram, M. Arfan (author)
Zelenika, Diana (author)
Vardarajan, Badri N. (author)
Kamatani, Yoichiro (author)
Lin, Chiao-Feng (author)
Schmidt, Helena (author)
Kunkle, Brian W. (author)
Dunstan, Melanie L. (author)
Ruiz, Agustin (author)
Bihoreau, Marie-Therese (author)
Reitz, Christiane (author)
Pasquier, Florence (author)
Hollingworth, Paul (author)
Hanon, Olivier (author)
Fitzpatrick, Annette L. (author)
Buxbaum, Joseph D. (author)
Campion, Dominique (author)
Crane, Paul K. (author)
Becker, Tim (author)
Gudnason, Vilmundur (author)
Cruchaga, Carlos (author)
Karolinska Institutet
Craig, David (author)
Amin, Najaf (author)
Berr, Claudine (author)
Lopez, Oscar L. (author)
De Jager, Philip L. (author)
Deramecourt, Vincent (author)
Johnston, Janet A. (author)
Evans, Denis (author)
Lovestone, Simon (author)
Letteneur, Luc (author)
Karolinska Institutet
Kornhuber, Johanes (author)
Tarraga, Lluis (author)
Rubinsztein, David C. (author)
Eiriksdottir, Gudny (author)
Sleegers, Kristel (author)
Goate, Alison M. (author)
Fievet, Nathalie (author)
Huentelman, Matthew J. (author)
Gill, Michael (author)
Emilsson, Valur (author)
Brown, Kristelle (author)
Kamboh, M. Ilyas (author)
Keller, Lina (author)
Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
Barberger-Gateau, Pascale (author)
McGuinness, Bernadette (author)
Larson, Eric B. (author)
Myers, Amanda J. (author)
Dufouil, Carole (author)
Todd, Stephen (author)
Wallon, David (author)
Love, Seth (author)
Kehoe, Pat (author)
Rogaeva, Ekaterina (author)
Gallacher, John (author)
St George-Hyslop, Peter (author)
Clarimon, Jordi (author)
Lleo, Alberti (author)
Bayer, Anthony (author)
Tsuang, Debby W. (author)
Yu, Lei (author)
Tsolaki, Magda (author)
Bossu, Paola (author)
Spalletta, Gianfranco (author)
Proitsi, Petra (author)
Collinge, John (author)
Sorbi, Sandro (author)
Garcia, Fiorentino Sanchez (author)
Fox, Nick (author)
Hardy, John (author)
Deniz Naranjo, Maria Candida (author)
Razquin, Cristina (author)
Bosco, Paola (author)
Clarke, Robert (author)
Brayne, Carol (author)
Galimberti, Daniela (author)
Mancuso, Michelangelo (author)
Moebus, Susanne (author)
Mecocci, Patrizia (author)
del Zompo, Maria (author)
Maier, Wolfgang (author)
Hampel, Harald (author)
Pilotto, Alberto (author)
Bullido, Maria (author)
Panza, Francesco (author)
Caffarra, Paolo (author)
Nacmias, Benedetta (author)
Gilbert, John R. (author)
Mayhaus, Manuel (author)
Jessen, Frank (author)
Dichgans, Martin (author)
Lannfelt, Lars (author)
Hakonarson, Hakon (author)
Pichler, Sabrina (author)
Carrasquillo, Minerva M. (author)
Ingelsson, Martin (author)
Uppsala universitet,Geriatrik
Beekly, Duane (author)
Alavarez, Victoria (author)
Zou, Fanggeng (author)
Valladares, Otto (author)
Younkin, Steven G. (author)
Coto, Eliecer (author)
Hamilton-Nelson, Kara L. (author)
Mateo, Ignacio (author)
Owen, Michael J. (author)
Faber, Kelley M. (author)
Jonsson, Palmi V. (author)
Combarros, Onofre (author)
O'Donovan, Michael C. (author)
Cantwell, Laura B. (author)
Soininen, Hilkka (author)
Blacker, Deborah (author)
Mead, Simon (author)
Mosley, Thomas H. (author)
Bennett, David A. (author)
Harris, Tamara B. (author)
Fratiglioni, Laura (author)
Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska University Hospital, Sweden
Holmes, Clive (author)
de Bruijn, Renee F. A. G. (author)
Passmore, Peter (author)
Montine, Thomas J. (author)
Bettens, Karolien (author)
Rotter, Jerome I. (author)
Brice, Alexis (author)
Morgan, Kevin (author)
Foroud, Tatiana M. (author)
Kukull, Walter A. (author)
Hannequin, Didier (author)
Powell, John F. (author)
Nails, Michael A. (author)
Ritchie, Karen (author)
Lunetta, Kathryn L. (author)
Kauwe, John S. K. (author)
Boerwinkle, Eric (author)
Riemenschneider, Matthias (author)
Boada, Merce (author)
Hiltunen, Mikko (author)
Martin, Eden R. (author)
Pastor, Pau (author)
Schmidt, Reinhold (author)
Rujescu, Dan (author)
Dartigues, Jean-Francois (author)
Mayeux, Richard (author)
Tzourio, Christophe (author)
Hofman, Albert (author)
Noethen, Markus M. (author)
Graff, Caroline (author)
Psaty, Bruce M. (author)
Haines, Jonathan L. (author)
Lathrop, Mark (author)
Pericak-Vance, Margaret A. (author)
Launer, Lenore J. (author)
Farrer, Lindsay A. (author)
van Duijn, Cornelia M. (author)
Van Broeckhoven, Christine (author)
Ramirez, Alfredo (author)
Schellenberg, Gerard D. (author)
Seshadri, Sudha (author)
Amouyel, Philippe (author)
Williams, Julie (author)
Holmans, Peter A. (author)
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 (creator_code:org_t)
2014-12-19
2015
English.
In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Alzheimer's disease
Dementia
Neurodegeneration
Immune response
Endocytosis
Cholesterol metabolism
Ubiquitination
Pathway analysis
ALIGATOR
Weighted gene co-expression network analysis

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Jones, Lesley
Lambert, Jean-Ch ...
Wang, Li-San
Choi, Seung-Hoan
Harold, Denise
Vedernikov, Alex ...
show more...
Escott-Price, Va ...
Stone, Timothy
Richards, Alexan ...
Bellenguez, Celi ...
Ibrahim-Verbaas, ...
Naj, Adam C.
Sims, Rebecca
Gerrish, Amy
Jun, Gyungah
Lannfelt, Lars
Bis, Joshua C.
Beecham, Gary W.
Grenier-Boley, B ...
Russo, Giancarlo
Thornton-Wells, ...
Jones, Nicola
Smith, Albert V.
Chouraki, Vincen ...
Thomas, Charlene
Ikram, M. Arfan
Zelenika, Diana
Vardarajan, Badr ...
Kamatani, Yoichi ...
Lin, Chiao-Feng
Schmidt, Helena
Kunkle, Brian W.
Dunstan, Melanie ...
Ruiz, Agustin
Bihoreau, Marie- ...
Reitz, Christian ...
Pasquier, Floren ...
Hollingworth, Pa ...
Hanon, Olivier
Fitzpatrick, Ann ...
Buxbaum, Joseph ...
Campion, Dominiq ...
Crane, Paul K.
Becker, Tim
Gudnason, Vilmun ...
Cruchaga, Carlos
Craig, David
Amin, Najaf
Berr, Claudine
Lopez, Oscar L.
De Jager, Philip ...
Deramecourt, Vin ...
Johnston, Janet ...
Evans, Denis
Lovestone, Simon
Letteneur, Luc
Kornhuber, Johan ...
Tarraga, Lluis
Rubinsztein, Dav ...
Eiriksdottir, Gu ...
Sleegers, Kriste ...
Goate, Alison M.
Fievet, Nathalie
Huentelman, Matt ...
Gill, Michael
Emilsson, Valur
Brown, Kristelle
Kamboh, M. Ilyas
Keller, Lina
Barberger-Gateau ...
McGuinness, Bern ...
Larson, Eric B.
Myers, Amanda J.
Dufouil, Carole
Todd, Stephen
Wallon, David
Love, Seth
Kehoe, Pat
Rogaeva, Ekateri ...
Gallacher, John
St George-Hyslop ...
Clarimon, Jordi
Lleo, Alberti
Bayer, Anthony
Tsuang, Debby W.
Yu, Lei
Tsolaki, Magda
Bossu, Paola
Spalletta, Gianf ...
Proitsi, Petra
Collinge, John
Sorbi, Sandro
Garcia, Fiorenti ...
Fox, Nick
Hardy, John
Deniz Naranjo, M ...
Razquin, Cristin ...
Bosco, Paola
Clarke, Robert
Brayne, Carol
Galimberti, Dani ...
Mancuso, Michela ...
Moebus, Susanne
Mecocci, Patrizi ...
del Zompo, Maria
Maier, Wolfgang
Hampel, Harald
Pilotto, Alberto
Bullido, Maria
Panza, Francesco
Caffarra, Paolo
Nacmias, Benedet ...
Gilbert, John R.
Mayhaus, Manuel
Jessen, Frank
Dichgans, Martin
Hakonarson, Hako ...
Pichler, Sabrina
Carrasquillo, Mi ...
Ingelsson, Marti ...
Beekly, Duane
Alavarez, Victor ...
Zou, Fanggeng
Valladares, Otto
Younkin, Steven ...
Coto, Eliecer
Hamilton-Nelson, ...
Mateo, Ignacio
Owen, Michael J.
Faber, Kelley M.
Jonsson, Palmi V ...
Combarros, Onofr ...
O'Donovan, Micha ...
Cantwell, Laura ...
Soininen, Hilkka
Blacker, Deborah
Mead, Simon
Mosley, Thomas H ...
Bennett, David A ...
Harris, Tamara B ...
Fratiglioni, Lau ...
Holmes, Clive
de Bruijn, Renee ...
Passmore, Peter
Montine, Thomas ...
Bettens, Karolie ...
Rotter, Jerome I ...
Brice, Alexis
Morgan, Kevin
Foroud, Tatiana ...
Kukull, Walter A ...
Hannequin, Didie ...
Powell, John F.
Nails, Michael A ...
Ritchie, Karen
Lunetta, Kathryn ...
Kauwe, John S. K ...
Boerwinkle, Eric
Riemenschneider, ...
Boada, Merce
Hiltunen, Mikko
Martin, Eden R.
Pastor, Pau
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Rujescu, Dan
Dartigues, Jean- ...
Mayeux, Richard
Tzourio, Christo ...
Hofman, Albert
Noethen, Markus ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
Articles in the publication
Alzheimer's & De ...
By the university
Stockholm University
Karolinska Institutet
Uppsala University

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