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Sökning: WFRF:(Rujescu Dan) > (2010-2014) > Hampel Harald

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Numrering	Referens	Omslagsbild	Hitta
1.	Escott-Price, Valentina, et al. (författare) Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease 2014 Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6, s. e94661- Tidskriftsartikel (refereegranskat)abstract Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
2.	Lautner, Ronald, et al. (författare) Apolipoprotein e genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease. 2014 Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 71:10, s. 1183-91 Tidskriftsartikel (refereegranskat)abstract Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
3.	Schneider, Philine, et al. (författare) Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment. 2011 Ingår i: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 70:2, s. 145-51 Tidskriftsartikel (refereegranskat)abstract Hypertension is a major risk factor of Alzheimer's disease (AD); however, controlled studies on the effect of antihypertensive treatment on the risk of dementia are inconclusive. Therefore, a biological marker that predicts individual response to antihypertensive treatment would be of high clinical relevance. Midregional proatrial natriuretic peptide (MR-proANP), an inactive surrogate molecule of the mature atrial natriuretic peptide, is related to circulatory function and hypertension.

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Blennow, Kaj, 1958 (2); Minthon, Lennart (2); Zetterberg, Henrik, ... (2); Hansson, Oskar (2); Boada, Mercè (1); Tsolaki, Magda (1); visa fler...; Pasquier, Florence (1); Wallin, Anders, 1950 (1); Landén, Mikael, 1966 (1); Powell, John F. (1); Ingelsson, Martin (1); Lannfelt, Lars (1); Fratiglioni, Laura (1); Clarke, Robert (1); Olsson, Bob, 1969 (1); Ramirez, Alfredo (1); Ikram, M. Arfan (1); Amin, Najaf (1); van Duijn, Cornelia ... (1); Palmqvist, Sebastian (1); Hiltunen, Mikko (1); Rotter, Jerome I. (1); Soininen, Hilkka (1); Van Broeckhoven, Chr ... (1); Fox, Nick C (1); Lleó, Alberto (1); Clarimon, Jordi (1); Ewers, Michael (1); Cruchaga, Carlos (1); Wallon, David (1); Hardy, John (1); Andreasson, Ulf, 196 ... (1); Lathrop, Mark (1); Graff, Caroline (1); Del Zompo, Maria (1); Nalls, Michael A. (1); Schmidt, Reinhold (1); Schmidt, Helena (1); Lautner, Ronald (1); Mattsson, Niklas, 19 ... (1); Pilotto, Alberto (1); Hakonarson, Hakon (1); Buxbaum, Joseph D (1); Gill, Michael (1); Haines, Jonathan L (1); Pericak-Vance, Marga ... (1); Schellenberg, Gerard ... (1); Lopez, Oscar L. (1); Choi, Seung Hoan (1); Huentelman, Matthew ... (1); visa färre...

Lärosäte: Göteborgs universitet (2); Lunds universitet (2); Karolinska Institutet (2); Uppsala universitet (1); Stockholms universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

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