Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, Niamh (author)

Kang, JooEun (author)

Campos, Adrian I. (author)

Coleman, Jonathan R. I. (author)

Edwards, Alexis C. (author)

Galfalvy, Hanga (author)

Levey, Daniel F. (author)

Lori, Adriana (author)

Shabalin, Andrey (author)

Starnawska, Anna (author)

Su, Mei-Hsin (author)

Watson, Hunna J. (author)

Adams, Mark (author)

Awasthi, Swapnil (author)

Gandal, Michael (author)

Hafferty, Jonathan D. (author)

Hishimoto, Akitoyo (author)

Kim, Minsoo (author)

Okazaki, Satoshi (author)

Otsuka, Ikuo (author)

Ripke, Stephan (author)

Ware, Erin B. (author)

Bergen, Andrew W. (author)

Berrettini, Wade H. (author)

Bohus, Martin (author)

Brandt, Harry (author)

Chang, Xiao (author)

Chen, Wei J. (author)

Chen, Hsi-Chung (author)

Crawford, Steven (author)

Crow, Scott (author)

DiBlasi, Emily (author)

Duriez, Philibert (author)

Fernández-Aranda, Fernando (author)

Fichter, Manfred M. (author)

Gallinger, Steven (author)

Glatt, Stephen J. (author)

Gorwood, Philip (author)

Guo, Yiran (author)

Hakonarson, Hakon (author)

Halmi, Katherine A. (author)

Hwu, Hai-Gwo (author)

Jain, Sonia (author)

Jamain, Stéphane (author)

Jiménez-Murcia, Susana (author)

Johnson, Craig (author)

Kaplan, Allan S. (author)

Kaye, Walter H. (author)

Keel, Pamela K. (author)

Kennedy, James L. (author)

Klump, Kelly L. (author)

Li, Dong (author)

Liao, Shih-Cheng (author)

Lieb, Klaus (author)

Lilenfeld, Lisa (author): Karolinska Institutet

Liu, Chih-Min (author)

Magistretti, Pierre J. (author)

Marshall, Christian R. (author)

Mitchell, James E. (author)

Monson, Eric T. (author)

Myers, Richard M. (author)

Pinto, Dalila (author)

Powers, Abigail (author)

Ramoz, Nicolas (author)

Roepke, Stefan (author)

Rozanov, Vsevolod (author)

Scherer, Stephen W. (author)

Schmahl, Christian (author)

Sokolowski, Marcus (author): Karolinska Institutet

Strober, Michael (author)

Thornton, Laura M. (author)

Treasure, Janet (author)

Tsuang, Ming T. (author)

Witt, Stephanie H. (author)

Woodside, D. Blake (author)

Yilmaz, Zeynep (author)

Zillich, Lea (author)

Adolfsson, Rolf (author): Umeå universitet,Psykiatri

Agartz, Ingrid (author): Karolinska Institutet

Air, Tracy M. (author)

Alda, Martin (author)

Alfredsson, Lars (author)

Andreassen, Ole A. (author)

Anjorin, Adebayo (author)

Appadurai, Vivek (author)

Soler Artigas, María (author)

Van der Auwera, Sandra (author)

Azevedo, M. Helena (author)

Bass, Nicholas (author)

Bau, Claiton H. D. (author)

Baune, Bernhard T. (author)

Bellivier, Frank (author)

Berger, Klaus (author)

Biernacka, Joanna M. (author)

Bigdeli, Tim B. (author)

Binder, Elisabeth B. (author)

Boehnke, Michael (author)

Boks, Marco P. (author)

Bosch, Rosa (author)

Braff, David L. (author)

Bryant, Richard (author)

Budde, Monika (author)

Byrne, Enda M. (author)

Cahn, Wiepke (author)

Casas, Miguel (author): Karolinska Institutet

Castelao, Enrique (author)

Cervilla, Jorge A. (author)

Chaumette, Boris (author)

Cichon, Sven (author)

Corvin, Aiden (author)

Craddock, Nicholas (author)

Craig, David (author)

Degenhardt, Franziska (author)

Djurovic, Srdjan (author)

Edenberg, Howard J. (author)

Fanous, Ayman H. (author)

Foo, Jerome C. (author)

Forstner, Andreas J. (author)

Frye, Mark (author)

Fullerton, Janice M. (author)

Gatt, Justine M. (author)

Gejman, Pablo V. (author)

Giegling, Ina (author)

Grabe, Hans J. (author)

Green, Melissa J. (author)

Grevet, Eugenio H. (author)

Grigoroiu-Serbanescu, Maria (author)

Gutierrez, Blanca (author)

Guzman-Parra, Jose (author)

Hamilton, Steven P. (author)

Hamshere, Marian L. (author)

Hartmann, Annette (author)

Hauser, Joanna (author)

Heilmann-Heimbach, Stefanie (author)

Hoffmann, Per (author)

Ising, Marcus (author)

Jones, Ian (author)

Jones, Lisa A. (author)

Jonsson, Lina, 1982 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Kahn, René S. (author)

Kelsoe, John R. (author)

Kendler, Kenneth S. (author)

Kloiber, Stefan (author)

Koenen, Karestan C. (author)

Kogevinas, Manolis (author)

Konte, Bettina (author)

Krebs, Marie-Odile (author)

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Lawrence, Jacob (author)

Leboyer, Marion (author)

Lee, Phil H. (author)

Levinson, Douglas F. (author)

Liao, Calwing (author)

Lissowska, Jolanta (author)

Lucae, Susanne (author)

Mayoral, Fermin (author)

McElroy, Susan L. (author)

McGrath, Patrick (author)

McGuffin, Peter (author)

McQuillin, Andrew (author)

Medland, Sarah E. (author)

Mehta, Divya (author)

Melle, Ingrid (author)

Milaneschi, Yuri (author)

Mitchell, Philip B. (author)

Molina, Esther (author)

Morken, Gunnar (author)

Mortensen, Preben Bo (author)

Müller-Myhsok, Bertram (author)

Nievergelt, Caroline (author)

Nimgaonkar, Vishwajit (author)

Nöthen, Markus M. (author)

O'Donovan, Michael C. (author)

Ophoff, Roel A. (author)

Owen, Michael J. (author)

Pato, Carlos (author)

Pato, Michele T. (author)

Penninx, Brenda W. J. H. (author)

Pimm, Jonathan (author)

Pistis, Giorgio (author)

Potash, James B. (author)

Power, Robert A. (author)

Preisig, Martin (author)

Quested, Digby (author)

Ramos-Quiroga, Josep Antoni (author)

Reif, Andreas (author)

Ribasés, Marta (author)

Richarte, Vanesa (author)

Rietschel, Marcella (author)

Rivera, Margarita (author)

Roberts, Andrea (author)

Roberts, Gloria (author)

Rouleau, Guy A. (author)

Rovaris, Diego L. (author)

Rujescu, Dan (author)

Sánchez-Mora, Cristina (author)

Sanders, Alan R. (author)

Schofield, Peter R. (author)

Schulze, Thomas G. (author)

Scott, Laura J. (author)

Serretti, Alessandro (author)

Shi, Jianxin (author)

Shyn, Stanley I. (author)

Sirignano, Lea (author)

Sklar, Pamela (author)

Smeland, Olav B. (author)

Smoller, Jordan W. (author)

Sonuga-Barke, Edmund J. S. (author)

Spalletta, Gianfranco (author)

Strauss, John S. (author)

Świątkowska, Beata (author)

Trzaskowski, Maciej (author)

Turecki, Gustavo (author)

Vilar-Ribó, Laura (author)

Vincent, John B. (author)

Völzke, Henry (author)

Walters, James T. R. (author)

Shannon Weickert, Cynthia (author)

Weickert, Thomas W. (author)

Weissman, Myrna M. (author)

Williams, Leanne M. (author)

Wray, Naomi R. (author)

Zai, Clement C. (author)

Ashley-Koch, Allison E. (author)

Beckham, Jean C. (author)

Hauser, Elizabeth R. (author)

Hauser, Michael A. (author)

Kimbrel, Nathan A. (author)

Lindquist, Jennifer H. (author)

McMahon, Benjamin (author)

Oslin, David W. (author): Karolinska Institutet

Qin, Xuejun (author)

Agerbo, Esben (author)

Børglum, Anders D. (author)

Breen, Gerome (author)

Erlangsen, Annette (author)

Esko, Tõnu (author)

Gelernter, Joel (author)

Hougaard, David M. (author)

Kessler, Ronald C. (author)

Kranzler, Henry R. (author)

Li, Qingqin S. (author)

Martin, Nicholas G. (author)

McIntosh, Andrew M. (author)

Mors, Ole (author)

Nordentoft, Merete (author)

Olsen, Catherine M. (author)

Porteous, David (author)

Ursano, Robert J. (author)

Wasserman, Danuta (author)

Werge, Thomas (author)

Whiteman, David C. (author)

Bulik, Cynthia M. (author)

Coon, Hilary (author)

Demontis, Ditte (author)

Docherty, Anna R. (author)

Kuo, Po-Hsiu (author)

Lewis, Cathryn M. (author)

Mann, J. John (author)

Rentería, Miguel E. (author)

Smith, Daniel J. (author)

Stahl, Eli A. (author)

Stein, Murray B. (author)

Streit, Fabian (author)

Willour, Virginia (author)

Ruderfer, Douglas M. (author)

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(creator_code:org_t)

Elsevier, 2022
2022
English.
In: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 91:3, s. 313-327

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); http://www.biologica...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://gup.ub.gu.se...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.

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By the author/editor: Mullins, Niamh; Kang, JooEun; Campos, Adrian I ...; Coleman, Jonatha ...; Edwards, Alexis ...; Galfalvy, Hanga; show more...; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J.; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonath ...; Hishimoto, Akito ...; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ripke, Stephan; Ware, Erin B.; Bergen, Andrew W ...; Berrettini, Wade ...; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J.; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philiber ...; Fernández-Aranda ...; Fichter, Manfred ...; Gallinger, Steve ...; Glatt, Stephen J ...; Gorwood, Philip; Guo, Yiran; Hakonarson, Hako ...; Halmi, Katherine ...; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stéphane; Jiménez-Murcia, ...; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Keel, Pamela K.; Kennedy, James L ...; Klump, Kelly L.; Li, Dong; Liao, Shih-Cheng; Lieb, Klaus; Lilenfeld, Lisa; Liu, Chih-Min; Magistretti, Pie ...; Marshall, Christ ...; Mitchell, James ...; Monson, Eric T.; Myers, Richard M ...; Pinto, Dalila; Powers, Abigail; Ramoz, Nicolas; Roepke, Stefan; Rozanov, Vsevolo ...; Scherer, Stephen ...; Schmahl, Christi ...; Sokolowski, Marc ...; Strober, Michael; Thornton, Laura ...; Treasure, Janet; Tsuang, Ming T.; Witt, Stephanie ...; Woodside, D. Bla ...; Yilmaz, Zeynep; Zillich, Lea; Adolfsson, Rolf; Agartz, Ingrid; Air, Tracy M.; Alda, Martin; Alfredsson, Lars; Andreassen, Ole ...; Anjorin, Adebayo; Appadurai, Vivek; Soler Artigas, M ...; Van der Auwera, ...; Azevedo, M. Hele ...; Bass, Nicholas; Bau, Claiton H. ...; Baune, Bernhard ...; Bellivier, Frank; Berger, Klaus; Biernacka, Joann ...; Bigdeli, Tim B.; Binder, Elisabet ...; Boehnke, Michael; Boks, Marco P.; Bosch, Rosa; Braff, David L.; Bryant, Richard; Budde, Monika; Byrne, Enda M.; Cahn, Wiepke; Casas, Miguel; Castelao, Enriqu ...; Cervilla, Jorge ...; Chaumette, Boris; Cichon, Sven; Corvin, Aiden; Craddock, Nichol ...; Craig, David; Degenhardt, Fran ...; Djurovic, Srdjan; Edenberg, Howard ...; Fanous, Ayman H.; Foo, Jerome C.; Forstner, Andrea ...; Frye, Mark; Fullerton, Janic ...; Gatt, Justine M.; Gejman, Pablo V.; Giegling, Ina; Grabe, Hans J.; Green, Melissa J ...; Grevet, Eugenio ...; Grigoroiu-Serban ...; Gutierrez, Blanc ...; Guzman-Parra, Jo ...; Hamilton, Steven ...; Hamshere, Marian ...; Hartmann, Annett ...; Hauser, Joanna; Heilmann-Heimbac ...; Hoffmann, Per; Ising, Marcus; Jones, Ian; Jones, Lisa A.; Jonsson, Lina, 1 ...; Kahn, René S.; Kelsoe, John R.; Kendler, Kenneth ...; Kloiber, Stefan; Koenen, Karestan ...; Kogevinas, Manol ...; Konte, Bettina; Krebs, Marie-Odi ...; Landén, Mikael, ...; Lawrence, Jacob; Leboyer, Marion; Lee, Phil H.; Levinson, Dougla ...; Liao, Calwing; Lissowska, Jolan ...; Lucae, Susanne; Mayoral, Fermin; McElroy, Susan L ...; McGrath, Patrick; McGuffin, Peter; McQuillin, Andre ...; Medland, Sarah E ...; Mehta, Divya; Melle, Ingrid; Milaneschi, Yuri; Mitchell, Philip ...; Molina, Esther; Morken, Gunnar; Mortensen, Prebe ...; Müller-Myhsok, B ...; Nievergelt, Caro ...; Nimgaonkar, Vish ...; Nöthen, Markus M ...; O'Donovan, Micha ...; Ophoff, Roel A.; Owen, Michael J.; Pato, Carlos; Pato, Michele T.; Penninx, Brenda ...; Pimm, Jonathan; Pistis, Giorgio; Potash, James B.; Power, Robert A.; Preisig, Martin; Quested, Digby; Ramos-Quiroga, J ...; Reif, Andreas; Ribasés, Marta; Richarte, Vanesa; Rietschel, Marce ...; Rivera, Margarit ...; Roberts, Andrea; Roberts, Gloria; Rouleau, Guy A.; Rovaris, Diego L ...; Rujescu, Dan; Sánchez-Mora, Cr ...; Sanders, Alan R.; Schofield, Peter ...; Schulze, Thomas ...; Scott, Laura J.; Serretti, Alessa ...; Shi, Jianxin; Shyn, Stanley I.; Sirignano, Lea; Sklar, Pamela; Smeland, Olav B.; Smoller, Jordan ...; Sonuga-Barke, Ed ...; Spalletta, Gianf ...; Strauss, John S.; Świątkowska, Bea ...; Trzaskowski, Mac ...; Turecki, Gustavo; Vilar-Ribó, Laur ...; Vincent, John B.; Völzke, Henry; Walters, James T ...; Shannon Weickert ...; Weickert, Thomas ...; Weissman, Myrna ...; Williams, Leanne ...; Wray, Naomi R.; Zai, Clement C.; Ashley-Koch, All ...; Beckham, Jean C.; Hauser, Elizabet ...; Hauser, Michael ...; Kimbrel, Nathan ...; Lindquist, Jenni ...; McMahon, Benjami ...; Oslin, David W.; Qin, Xuejun; Agerbo, Esben; Børglum, Anders ...; Breen, Gerome; Erlangsen, Annet ...; Esko, Tõnu; Gelernter, Joel; Hougaard, David ...; Kessler, Ronald ...; Kranzler, Henry ...; Li, Qingqin S.; Martin, Nicholas ...; McIntosh, Andrew ...; Mors, Ole; Nordentoft, Mere ...; Olsen, Catherine ...; Porteous, David; Ursano, Robert J ...; Wasserman, Danut ...; Werge, Thomas; Whiteman, David ...; Bulik, Cynthia M ...; Coon, Hilary; Demontis, Ditte; Docherty, Anna R ...; Kuo, Po-Hsiu; Lewis, Cathryn M ...; Mann, J. John; Rentería, Miguel ...; Smith, Daniel J.; Stahl, Eli A.; Stein, Murray B.; Streit, Fabian; Willour, Virgini ...; Ruderfer, Dougla ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Biological Psych ...

By the university: Umeå University; Karolinska Institutet; University of Gothenburg

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

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