SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Rundek Tatjana) ;pers:(Willeit Johann)"

Sökning: WFRF:(Rundek Tatjana) > Willeit Johann

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Lorenz, Matthias W., et al. (författare)
  • Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project
  • 2010
  • Ingår i: American Heart Journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 159:5, s. 25-730
  • Tidskriftsartikel (refereegranskat)abstract
    • Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)
  •  
2.
  • Willeit, Peter, et al. (författare)
  • Inflammatory markers and extent and progression of early atherosclerosis : Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration
  • 2016
  • Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 23:2, s. 194-205
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundLarge-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. MethodsInformation on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. ResultsMean baseline CCA-IMT amounted to 0.74mm (SD=0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011mm/year (SD=0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082mm for high-sensitivity C-reactive protein (p<0.001); 0.0072mm for fibrinogen (p<0.001); and 0.0025mm for leucocyte count (p=0.033). Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p<0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest inflammatory load' had a greater CCA-IMT progression (p=0.015). ConclusionInflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Rundek, Tatjana (2)
Sacco, Ralph L. (2)
Catapano, Alberico L ... (2)
Kiechl, Stefan (2)
Mathiesen, Ellisiv B ... (2)
Willeit, Johann (2)Ta bort avgränsningen
visa fler...
Lorenz, Matthias W. (2)
Sitzer, Matthias (2)
Desvarieux, Moise (2)
Thompson, Simon G. (2)
Bickel, Horst (2)
Sander, Dirk (2)
Iglseder, Bernhard (2)
Norata, Giuseppe D. (2)
Bergström, Göran, 19 ... (1)
Agewall, Stefan (1)
Lind, Lars (1)
Rosvall, Maria (1)
Hedblad, Bo (1)
Bokemark, Lena, 1960 (1)
Fagerberg, Björn, 19 ... (1)
Schmidt, Caroline, 1 ... (1)
Ikram, M. Arfan (1)
Tuomainen, Tomi-Pekk ... (1)
Hofman, Albert (1)
Franco, Oscar H. (1)
Liu, Jing (1)
Voelzke, Henry (1)
Empana, Jean-Philipp ... (1)
Kavousi, Maryam (1)
McLachlan, Stela (1)
Ronkainen, Kimmo (1)
Zhao, Dong (1)
Chien, Kuo Liong (1)
Olsen, Michael H. (1)
Bots, Michiel L. (1)
Polak, Joseph F. (1)
Robertson, Christine (1)
Kauhanen, Jussi (1)
Breteler, Monique M. ... (1)
Witteman, Jacqueline (1)
Papagianni, Aikateri ... (1)
Willeit, Peter (1)
Ducimetière, Pierre (1)
Doerr, Marcus (1)
Price, Jackie F. (1)
Lin, Hung-Ju (1)
Plichart, Matthieu (1)
Johnsen, Stein Haral ... (1)
Juraska, Michal (1)
visa färre...
Lärosäte
Göteborgs universitet (1)
Uppsala universitet (1)
Lunds universitet (1)
Karolinska Institutet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy