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Sökning: WFRF:(SPURR N)

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  • Ulvsbäck, M., et al. (författare)
  • Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates
  • 1991
  • Ingår i: Genomics. - : Academic Press. - 1089-8646. ; 11:4, s. 4-920
  • Tidskriftsartikel (refereegranskat)abstract
    • The gene for beta-microseminoprotein MSMB has been studied by DNA hybridization and molecular cloning techniques. Comparative analysis of restriction endonuclease digests of the cloned gene and of leukocyte DNA strongly suggested that the gene is present in a single copy in the haploid human genome. By Southern blot analysis of DNA from somatic cell hybrids, the gene was assigned to chromosome 10. The coding nucleotides of the human gene are separated into four exons by relatively large introns. A related gene might be present in other mammals, birds, and amphibians as revealed by DNA hybridization under conditions of low stringency.
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  • Ulvsbäck, M., et al. (författare)
  • Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20
  • 1992
  • Ingår i: Journal of Biological Chemistry. - : ASBMB. - 0021-9258. ; 267:25, s. 4-18080
  • Tidskriftsartikel (refereegranskat)abstract
    • The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.
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  • Resultat 1-7 av 7

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