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  • Forquin, P., et al. (författare)
  • Investigation of the Mechanical Behaviour of Lingulid Sandstone Emphasising the Influence from Pre-Existing Structural Defects, Part 1 : Model Identification Based on Static Experiments
  • 2022
  • Ingår i: Applied Sciences. - : MDPI AG. - 2076-3417. ; 12:21, s. 10806-
  • Tidskriftsartikel (refereegranskat)abstract
    • A constitutive model able to describe both tensile damage and plastic deformation under confinement is a prerequisite to numerically simulate the behaviour of sandstone rock under an impact loading induced in a percussive drilling process. Therefore, model identification under both tensile and high confinement states is needed. In the present work, an experimental investigation was carried out in order to determine the mechanical properties of a sandstone rock for the purpose of advanced constitutive model identification. Different testing methods were used in quasistatic and dynamic loading regimes. This first part of the study is dedicated to static experiments, whereby three-point bend tests were first performed to evaluate the quasistatic tensile strength of the rock and its distribution by employing the Weibull statistics. Secondly, direct compression tests were conducted to evaluate the stiffness and strength in an unconfined condition. Afterwards, quasioedometric compression (QOC) tests were carried out in order to obtain the deviatoric and volumetric behaviours of the material as a function of the hydrostatic pressure (up to 375 MPa). In these QOC tests, the metallic confinement cell was instrumented with strain gauges to deduce the state of the stress and strain within the sample. A linear volumetric response along with a continuous increase of strength with the level of hydrostatic pressure was observed. This experimental work points out that, under unconfined loading (three-point bending and uniaxial compression), pre-existing structural defects play a major role leading to a highly scattered behaviour in terms of sample stiffness and ultimate applied load. On the other hand, under high confinement levels (QOC tests), beyond the nonlinear response of the curve foot, the influence from structural defects was observed to be small. 
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  • Saletti, D., et al. (författare)
  • The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model
  • 2017
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Matrix proteins from enveloped viruses play an important role in budding and stabilizing virus particles. In order to assess the role of the matrix protein M1 from influenza C virus (M1-C) in plasma membrane deformation, we have combined structural and in vitro reconstitution experiments with model membranes. We present the crystal structure of the N-terminal domain of M1-C and show by Small Angle X-Ray Scattering analysis that full-length M1-C folds into an elongated structure that associates laterally into ring-like or filamentous polymers. Using negatively charged giant unilamellar vesicles (GUVs), we demonstrate that M1-C full-length binds to and induces inward budding of membrane tubules with diameters that resemble the diameter of viruses. Membrane tubule formation requires the C-terminal domain of M1-C, corroborating its essential role for M1-C polymerization. Our results indicate that M1-C assembly on membranes constitutes the driving force for budding and suggest that M1-C plays a key role in facilitating viral egress.
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  • Resultat 1-3 av 3

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