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Träfflista för sökning "WFRF:(Sarchiapone M) ;pers:(Roy A.)"

Sökning: WFRF:(Sarchiapone M) > Roy A.

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  • Carli, V, et al. (författare)
  • Self-harm in prisoners
  • 2011
  • Ingår i: CNS spectrums. - 1092-8529. ; 16:3, s. 75-81
  • Tidskriftsartikel (refereegranskat)
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  • Sarchiapone, M, et al. (författare)
  • Family history of suicide and personality
  • 2009
  • Ingår i: Archives of suicide research : official journal of the International Academy for Suicide Research. - 1543-6136. ; 13:2, s. 178-184
  • Tidskriftsartikel (refereegranskat)
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  • Carli, V, et al. (författare)
  • A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population
  • 2011
  • Ingår i: European psychiatry : the journal of the Association of European Psychiatrists. - : Cambridge University Press (CUP). - 1778-3585. ; 26:8, s. 471-478
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.
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  • Resultat 1-10 av 25

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