SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Sattar N) "

Sökning: WFRF:(Sattar N)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • 2021
  • swepub:Mat__t
  •  
2.
  •  
3.
  • Justice, A. E., et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  • Lumbers, R. T., et al. (författare)
  • The genomics of heart failure: design and rationale of the HERMES consortium
  • 2021
  • Ingår i: Esc Heart Failure. - : John Wiley & Sons Inc.. - 2055-5822. ; 8:6, s. 5531-5541
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (128)
konferensbidrag (3)
Typ av innehåll
refereegranskat (123)
övrigt vetenskapligt (8)
Författare/redaktör
Sattar, N. (88)
Sattar, Naveed (35)
Ford, I. (26)
Trompet, Stella (26)
Ford, Ian (25)
Jukema, J. Wouter (25)
visa fler...
Lind, Lars (22)
Wareham, Nicholas J. (22)
Asselbergs, Folkert ... (22)
Trompet, S (21)
Langenberg, Claudia (21)
Mahajan, Anubha (20)
Deloukas, Panos (19)
Scott, Robert A (19)
Palmer, Colin N. A. (19)
McCarthy, Mark I (18)
Samani, Nilesh J. (18)
Loos, Ruth J F (18)
Salomaa, Veikko (17)
Laakso, Markku (17)
Hamsten, A (17)
Boehnke, Michael (17)
Hofman, A (17)
Boerwinkle, Eric (17)
Perola, Markus (16)
Gudnason, V (16)
Ridker, Paul M. (16)
Chasman, Daniel I. (16)
Ingelsson, Erik (16)
Metspalu, Andres (16)
Di Angelantonio, E (16)
van der Harst, Pim (16)
Gudnason, Vilmundur (15)
Rotter, Jerome I. (15)
Uitterlinden, Andre ... (15)
Rosengren, Annika, 1 ... (15)
Kuusisto, Johanna (15)
Mohlke, Karen L (15)
Tuomilehto, Jaakko (15)
Salomaa, V (15)
Hayward, Caroline (15)
Boerwinkle, E (14)
Linneberg, Allan (14)
Grarup, Niels (14)
Pedersen, Oluf (14)
Hansen, Torben (14)
Verweij, Niek (14)
Peters, Annette (14)
Munroe, Patricia B. (14)
van der Harst, P. (14)
visa färre...
Lärosäte
Karolinska Institutet (54)
Göteborgs universitet (44)
Uppsala universitet (35)
Lunds universitet (24)
Umeå universitet (19)
Linköpings universitet (4)
visa fler...
Örebro universitet (3)
Stockholms universitet (2)
Jönköping University (2)
Chalmers tekniska högskola (1)
Linnéuniversitetet (1)
visa färre...
Språk
Engelska (132)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (80)
Naturvetenskap (8)
Lantbruksvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy