SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Sattar Naveed) ;lar1:(su)"

Sökning: WFRF:(Sattar Naveed) > Stockholms universitet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • de Vries, Paul S., et al. (författare)
  • Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study
  • 2017
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were associated using both HapMap and 1000G imputation. One locus identified using HapMap imputation was not significant using 1000G imputation. The genome-wide significance threshold of 5x10(-8) is based on the number of independent statistical tests using HapMap imputation, and 1000G imputation may lead to further independent tests that should be corrected for. When using a stricter Bonferroni correction for the 1000G GWA study (P-value < 2.5x10(-8)), the number of loci significant only using HapMap imputation increased to 4 while the number of loci significant only using 1000G decreased to 5. In conclusion, 1000G imputation enabled the identification of 20% more loci than HapMap imputation, although the advantage of 1000G imputation became less clear when a stricter Bonferroni correction was used. More generally, our results provide insights that are applicable to the implementation of other dense reference panels that are under development.
  •  
2.
  • Rosengren, Annika, 1951, et al. (författare)
  • Severe COVID-19 in people 55 and older during the first year of the pandemic in Sweden
  • 2022
  • Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796 .- 0955-7873. ; 292:4, s. 641-653
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Exposure to many contacts is the main risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, while risk of serious disease and death is chiefly determined by old age and comorbidities. Relative and population-attributable fractions (PAFs) of multiple medical and social exposures for COVID-19 outcomes have not been evaluated among older adults. Objectives We describe the effect of multiple exposures on the odds of testing positive for the virus and of severe disease (hospital care or death) and PAFs in Swedish citizens aged 55 years and above. Methods We used national registers to follow all citizens aged 55 years and above with respect to (1) testing positive, (2) hospitalization, and (3) death between 31 January 2020 and 1 February 2021. Results Of 3,410,241 persons, 156,017 (4.6%, mean age 68.3 years) tested positive for SARS-CoV-2, while 35,999 (1.1%, mean age 76.7 years) were hospitalized or died (12,384 deaths, 0.4%, mean age 84.0 years). Among the total cohort, the proportion living without home care or long-term care was 98.8% among persons aged 55-64 and 22.1% of those aged 95 and above. After multiple adjustment, home care and long-term care were associated with odds ratios of 7.9 (95% confidence interval [CI] 6.8-9.1) and 22.5 (95% CI 19.6-25.7) for mortality, with PAFs of 21.9% (95% CI 20.9-22.9) and 33.3% (95% CI 32.4-34.3), respectively. Conclusion Among Swedish residents aged 55 years and above, those with home care or long-term care had markedly increased risk for COVID-19 death during the first year of the pandemic, with over 50% of deaths attributable to these factors.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Sattar, Naveed (2)
Lagergren, J (1)
Gisslén, Magnus, 196 ... (1)
Rosengren, Annika, 1 ... (1)
Adiels, Martin, 1976 (1)
Strachan, David P (1)
visa fler...
Åberg, Maria A I, 19 ... (1)
Robertson, Josefina (1)
Ahluwalia, Tarunveer ... (1)
Hansen, Torben (1)
Ridker, Paul M. (1)
Chasman, Daniel I. (1)
Rose, Lynda M (1)
Hamsten, Anders (1)
Björk, Jonas (1)
Rotter, Jerome I. (1)
Mangino, Massimo (1)
de Geus, Eco J. C. (1)
Boomsma, Dorret I. (1)
Spector, Tim D. (1)
Lindgren, Martin (1)
Deary, Ian J (1)
Edqvist, Jon, 1988 (1)
Cucca, Francesco (1)
Brandén, Maria, 1982 ... (1)
Weng, Lu Chen (1)
Rivadeneira, Fernand ... (1)
Zeller, Tanja (1)
Lopez, Lorna M (1)
Hysi, Pirro G (1)
Hofman, Albert (1)
Starr, John M (1)
Uitterlinden, André ... (1)
McArdle, Wendy L (1)
Morrison, Alanna C (1)
Psaty, Bruce M (1)
Brody, Jennifer A. (1)
Franco, Oscar H. (1)
McKnight, Barbara (1)
O'Donnell, Christoph ... (1)
Kleber, Marcus E. (1)
Maerz, Winfried (1)
Watkins, Hugh (1)
Venturini, Cristina (1)
De Maat, Moniek P. M ... (1)
Söderberg, Mia, 1977 (1)
Greinacher, Andreas (1)
Holliday, Elizabeth ... (1)
Cronie, Ottmar, 1979 (1)
Tanaka, Toshiko (1)
visa färre...
Lärosäte
Stockholms universitet  (2)Ta bort avgränsningen
Karolinska Institutet (2)
Göteborgs universitet (1)
Linköpings universitet (1)
Lunds universitet (1)
Chalmers tekniska högskola (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy